Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0001127 (respiratory acidosis)
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Human Gene/Protein
SLC9A2 11.1
Kir5.1 10.5
DMO 10.3
Kir4.2 9.2
KHS 9.1
IDI1 9.1
Brain acyl-CoA hydrolase 9.1
SLC9A3 8.7
GPR4 8.6
UPP 8.5
BCO2 8.5
Na/H antiporter 8.4
INSIG1 8.4
congenital chloride diarrhea 8.2
Kir2.3 8.2
anion exchange protein 8.1
TWIK-1 8.0
OGR1 8.0
Kir1.1 8.0
Kir4.1 8.0
KLP 8.0
CA V 7.7
NBC1 7.7
CAIV 7.5
leu5 7.5
SLC26A3 7.5
CA IV 7.5
NHE-3 7.5
CO2 7.3
SHS 7.1
mm-1 7.1
TB1 7.1
carbonic anhydrase 7.0
phosphate-activated glutaminase 7.0
TB2 7.0
vacuolar-type H(+)-ATPase 7.0
ABG 6.9
ATPase mRNA 6.9
ms2 6.8
PBF 6.8
pendrin 6.8
soluble adenylyl cyclase 6.8
OUT 6.7
Claudin-5 6.7
Glutaminase 6.7
NTS 6.6
NHE3 6.5
CRA 6.5
ACID 6.5
TASK-1 6.5
COPD 6.4
anion exchanger 1 6.4
SCN5A 6.4
rd1 6.3
TASK-3 6.3
NHE2 6.2
PHS 6.1
CPAP 6.1
DOB 6.1
HC1 6.0
KLF6 6.0
oxoglutarate 6.0
Limulus polyphemus 6.0
TRPM8 6.0
NBC 6.0
CA II 6.0
Carbonic anhydrase 5.9
extracellular superoxide dismutase 5.8
TPN 5.8
Kir6.1 5.8
RDS 5.8
proximal tubule 5.7
IK1 5.7
adenosinetriphosphatase 5.6
collecting duct 5.6
CPK 5.6
fructokinase 5.5
p20 5.4
P50 5.4
AEC 5.4
more...
Disease
Chronic respiratory acidosis 14.4
respiratory acidosis 14.4
Neonatal nephrocalcinosis 14.4
Carnitine palmitoyltransferase II deficiency 13.4
Acute respiratory acidosis 13.2
Central alveolar hypoventilation syndrome 13.1
LACH 12.8
Chronic hyperventilation 11.6
Vanishing lung 11.6
Acute respiratory alkalosis 11.1
Acute myopathy 10.7
Acid-base disorders 10.7
alkalosis 10.5
ethanolism 10.5
Fetal asphyxia 10.3
metabolic alkalosis 10.2
Proximal renal tubular acidosis 10.2
Cardiorespiratory failure 10.0
PCP intoxication 9.5
status asthmaticus 9.5
Postoperative pneumonia 9.5
hyperlysinemia 9.4
multifocal atrial tachycardia 9.2
Escherichia coli pneumonia 9.2
Diffuse alveolar damage 8.9
Obesity hypoventilation syndrome 8.8
hypochloremia 8.8
battered child syndrome 8.5
Gerhardt 8.5
Intestinal pseudo-obstruction 8.5
Emphysematous gastritis 8.4
aerophagia 8.3
hypothalamic disorder 8.3
Plastic bronchitis 8.3
Tension pneumocephalus 8.3
Burnett 8.3
Twin-twin transfusion syndrome 8.2
Hemodynamic instability 8.2
Distal renal tubular acidosis 8.1
Bronchopleural fistula 7.9
lymphangiectasis 7.9
alcoholic ketoacidosis 7.8
TCO 7.8
Abdominal compartment syndrome 7.7
Chronic mountain sickness 7.7
Tracheal stenosis 7.6
Ondine's curse 7.6
Ondine's curse 7.6
malignant hyperthermia 7.6
puerperal fever 7.5
Duodenum 7.4
Duodenum 7.4
neonatal asphyxia 7.4
pH increased 7.3
primary disorders 7.3
lactic acidosis 7.3
hepatosis 7.3
PIE 7.3
ARF 7.2
Meige syndrome 7.2
cor pulmonale 7.2
Central sleep apnea 7.2
circulatory disorder 7.1
SHS 7.1
respiratory failure 7.1
SHS 7.1
bronchomalacia 7.1
hypokalemic alkalosis 7.0
hyperchloremia 6.9
hyperventilation syndrome 6.9
reactive airway disease 6.9
Meigs' syndrome 6.9
hyperproteinemia 6.9
Ogilvie's syndrome 6.8
claustrophobia 6.7
eosinopenia 6.7
obstructive airway disease 6.7
Wallenberg's syndrome 6.6
adult respiratory distress syndrome 6.6
tension pneumothorax 6.6
more...
Symptom
Increased work of breathing 12.8
Mouth breathing 10.9
hypercapnia 10.0
abdominal rigidity 9.4
hypocapnia 8.5
generalized abdominal pain 7.8
phosphatemia 7.6
hyperoxia 6.7
asterixis 6.7
labored breathing 6.7
abnormal breathing 6.6
tachypnea 6.4
Anoxia 6.3
respiratory distress 6.1
cyanosis 6.1
rales 6.1
muscle rigidity 5.9
oliguria 5.8
consciousness disturbance 5.7
belching 5.7
orthopnea 5.5
rundown 5.4
lightheadedness 5.4
hypersomnia 5.3
sinus pressure 5.3
breath holding 5.2
hypothermia 5.2
excessive sweating 5.2
presyncope 5.1
neck stiffness 5.1
tonic-clonic seizure 5.0
Sedation 5.0
twitching 5.0
nasal discharge 5.0
anesthesia 4.9
clonus 4.8
dyspnea 4.8
lethargy 4.5
productive cough 4.2
nasal congestion 4.2
stridor 4.2
decreased appetite 4.2
hypotonia 4.2
wheezing 4.1
muscle stiffness 4.1
tingling 4.1
analgesia 3.8
paresis 3.4
chronic cough 3.4
fatigue 3.4
sleepiness 3.3
acidity 3.3
flank pain 3.3
exhaustion 3.2
rhinorrhea 3.2
spasm 3.1
paresthesia 3.1
pallor 3.1
shortness of breath 3.0
collapse 2.9
snoring 2.9
weakness 2.9
hoarseness 2.8
cough 2.8
cancer pain 2.8
nausea and vomiting 2.7
ophthalmoplegia 2.7
epigastric pain 2.6
vomiting 2.6
cerebellar ataxia 2.6
memory loss 2.6
dysarthria 2.5
neck pain 2.4
seizures 2.3
hepatosplenomegaly 2.3
functional recovery 2.2
numbness 2.0
ataxia 2.0
cachexia 1.9
agitation 1.8
more...
Drug
Carfentanil citrate 12.4
Fursultiamine 12.1
Benzonatate 10.7
Garamycin 9.9
Garamycin 9.8
Sivelestat sodium hydrate 9.8
Butorphanol tartrate 9.7
Garamycin 9.2
Propanidid 9.2
Sivelestat 8.8
Helium 7.9
Dantrolene sodium 7.6
Red ginseng 7.5
Atipamezole 7.0
Butorphanol 6.9
Medetomidine 6.7
Calcium chloride 6.6
Ammonium chloride 6.5
Tubocurarine 6.4
Sumatran 6.1
Vena 6.1
Vena 6.1
Meconium 6.0
Flunitrazepam 5.9
Zonisamide 5.8
Bupivacaine 5.8
SBT 5.8
Pregabalin 5.6
SF6 5.6
Papaverine 5.5
Amiloride 5.4
PFA 5.4
Propofol 5.3
Amiloride 5.1
Digitalis 5.1
Cremophor EL 5.1
Fentanyl 5.1
Theophylline 5.0
Secretin 4.9
CPR 4.7
NH3 4.6
Ringer's solution 4.5
Diphenhydramine 4.4
Ketoconazole 4.3
Phentolamine 4.2
Methylene blue 4.0
MgSO4 3.8
CSF 3.6
EPI 3.3
NAG 3.3
CaCl2 3.3
nitroglycerin 3.3
Clonidine 3.1
Imatinib 3.1
pyridoxal phosphate 3.1
Fraction 3.0
Nephron 2.8
CaCl2 2.7
CaCl2 2.7
Nephron 2.6
PCP 2.5
MAP 2.4
Portal 2.3
ENT 2.3
caffeine 2.3
CAM 1.9
Asthma 1.7
NADH 1.5
vitamin E 1.3
ROS 1.1
Ethanol 1.1
citric acid 1.1
Leaf 1.0
Dial 0.5
Cardiovasc 0.5
Monit 0.3
ascorbate -0.1
IL-2 -0.5
lysine -1.5
Dermatol -3.6
more...
Enzyme
carbonic anhydrase 7.0
fructokinase 5.9
lactate oxidase 5.8
tryptophan hydroxylase 5.2
glutaminase 5.1
type III procollagen 4.9
aldolase 4.6
adenosine kinase 4.5
SCS 4.4
5alpha-reductase 4.3
5alpha-reductase 4.3
pyruvate dehydrogenase 4.2
pyruvate dehydrogenase 4.2
CPS 4.1
alpha-ketoglutarate dehydrogenase 4.1
phosphoenolpyruvate carboxylase 3.6
pyruvate dehydrogenase 3.5
prostaglandin synthetase 3.5
MAP 3.5
botulinum neurotoxin 3.5
BAL 3.4
CaMKII 3.4
creatine kinase 3.3
renin 3.3
glutamate dehydrogenase 3.3
glutamate dehydrogenase 3.3
glutamate dehydrogenase 3.3
ADH 3.2
CPR 3.0
phosphorylase 2.9
ATPase 2.8
gamma-glutamyl transpeptidase 2.8
NO synthase 2.7
CPT 2.7
CPT 2.6
aspartate aminotransferase 2.6
arginase 2.5
PCP 2.5
alanine aminotransferase 2.5
phosphofructokinase 2.5
NADPH-diaphorase 2.4
xanthine oxidase 2.3
phosphoenolpyruvate carboxykinase 2.3
phosphoenolpyruvate carboxykinase 2.3
citrate synthase 2.2
CPT 2.2
malate dehydrogenase 2.2
alcohol dehydrogenase 2.2
phosphoenolpyruvate carboxykinase 2.2
lactate dehydrogenase 2.1
deaminase 2.1
pyruvate kinase 2.0
AST 1.8
papain 1.7
beta-glucuronidase 1.5
alkaline phosphatase 1.4
guanylate cyclase 1.3
pepsin 1.3
lipoxygenase 1.3
ACE 1.2
adenylate cyclase 1.1
tissue plasminogen activator 0.9
cholinesterase 0.7
acid phosphatase 0.7
thromboplastin 0.7
phospholipase A2 0.6
calcineurin 0.3
MEK 0.2
collagenase 0.2
phospholipase C 0.2
phosphodiesterase 0.2
ERK 0.2
glutathione peroxidase -0.1
protein kinase C -0.2
acetylcholinesterase -0.4
caspase-3 -0.8
luciferase -0.8
protein kinase -0.9
focal adhesion kinase -1.1
mitogen-activated protein kinase -1.2
more...
Compound
Ledacrine 13.4
Renese 12.8
DMO 10.4
Methazolamide 8.7
carbonic acid 8.5
carbonic acid 8.5
carbonic acid 8.5
carbonic acid 8.5
carbonic acid 8.5
carbonic acid 8.5
carbonic acid 8.5
carbonic acid 8.5
carbonic acid 8.5
carbonic acid 8.5
carbonic acid 8.4
carbonic acid 8.4
carbonic acid 8.4
carbonic acid 8.4
carbonic acid 8.4
carbonic acid 8.4
carbonic acid 8.4
carbonic acid 8.4
Rimantadine 8.2
Maneb 8.2
HCO 8.1
carbonic acid 8.0
Acetazolamide 8.0
carbonic acid 7.9
Dantrolene sodium 7.8
UPP 7.8
Sodium lactate 7.8
Copper sulfate 7.7
Pancuronium 7.6
Aminophylline 7.3
Ritodrine 7.3
Sevoflurane 7.2
Biocytin 7.2
Enflurane 7.1
SHS 7.1
C 6 7.1
Succinylcholine 7.1
DOA 7.0
Butorphanol 7.0
CO2 6.9
carbonate 6.8
Cardamine 6.7
DIDS 6.7
Zonisamide 6.7
DPG 6.7
Amax 6.6
Tubocurarine 6.6
Alfentanil 6.5
Nisoldipine 6.4
Propafenone 6.3
Allopregnanolone 6.3
Halothane 6.3
NCD 6.3
MHS 6.3
Allopregnanolone 6.2
Thiopental 6.2
DPG 6.2
2-phosphoglycerate 6.1
Etomidate 6.0
NBC 6.0
Meperidine 6.0
oxalacetate 5.8
2-hydroxyethyl 5.8
Bupivacaine 5.8
Nembutal 5.8
HCI 5.8
Theophylline 5.7
Dantrolene 5.7
Sotalol 5.7
Thiazide 5.7
SITS 5.6
Nicorandil 5.6
2,3-diphosphoglycerate 5.6
Phenoxybenzamine 5.6
Papaverine 5.5
Lindane 5.5
more...