Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0001127 (respiratory acidosis)
 1,501 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients with massive pulmonary embolism (PE) presented with generalized seizures. Pathophysiologic abnormalities that explain this clinical syndrome include respiratory acidosis, hypoxemia, and cerebral hypoperfusion due to decreased cardiac output. PE should be considered in the differential diagnosis of new-onset and otherwise unexplained seizures.
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PMID:Pulmonary embolism presenting as seizures. 963 29

An unusual case of thrombus formation in the arch vessels after cardiac arrest because of pulmonary embolism is reported. A 67-year-old woman developed pulmonary embolism that soon led to cardiac arrest. Although percutaneous cardiopulmonary support was started, the blood pressure of her upper extremity was below 20 mm Hg and blood gas analysis showed marked metabolic and respiratory acidosis. Transesophageal echocardiography revealed thrombus in the right pulmonary artery, thrombus with floppy movement in the aortic arch, and 3 arch branch arteries filled with thrombus with little blood flow around it. After thrombolytic therapy, the thrombi gradually shrunk and perfusion in the upper extremities improved. The patient was successfully weaned from percutaneous cardiopulmonary support and was discharged alive. Thrombus formation can occur in the arch branch arteries after cardiac arrest, causing unusual laboratory data. Transesophageal echocardiography is useful for obtaining real-time information in the cardiovascular system at bedside in such a critically ill patient.
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PMID:Thrombosed arch vessels after cardiac arrest because of pulmonary embolism. 1600 80

We report herein 6 cases of sudden cardiac arrest in alcoholic ketoacidosis (AKA). All cases displayed evidence of prolonged excessive alcohol consumption and elevated beta-hydroxybutyric acid levels and exhibited pulseless electrical activity (PEA) upon collapse. Severe metabolic acidosis was also seen in all cases. Some cases also displayed concomitant respiratory acidosis, hypothermia, hypoxia and/or hemorrhage. No evidence of myocardial infarction, tamponade or right heart strain, which would suggest pulmonary embolism, was found on cardiac ultrasonography. As PEA in AKA is induced by severe metabolic acidosis, aggressive correction of acidosis may represent a useful therapeutic strategy for such patients.
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PMID:Six cases of sudden cardiac arrest in alcoholic ketoacidosis. 1819 1

The rapidly expanding cases of the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have exposed vulnerable populations, including pregnant women to an unprecedented public health crisis. Recent data show that pregnancy in COVID-19 patients is associated with increased hospitalization, admission of the intensive care unit, and intubation. However, very few resources exist to guide the multidisciplinary team in managing critically ill pregnant women with COVID-19. We report our experience with managing a morbidly obese pregnant woman at 36 weeks' gestation with history of asthma and malignancy who presented with persistent respiratory symptoms at an outside hospital after being tested positive for SARS-CoV-2 polymerase chain reaction (PCR). Early in the course of the hospitalization, patient received remdesivir, convalescent plasma, bronchodilator, systemic steroids, and IV heparin for COVID-19 and concomitant asthma exacerbation and pulmonary embolism. Due to increasing oxygen requirements, she was eventually intubated and transferred to our institution for higher level of care. Respiratory acidosis, severe hypoxemia, and vent asynchrony were managed with vent setting adjustment and paralytics. After 12 hours from spontaneous rupture of her membranes and with stabilization of maternal status, patient underwent a term cesarean delivery for nonreassuring fetal heart tracing. The neonate was discharged on the 2nd day of life, while the patient was extubated on the 6th postpartum day and was discharged to acute inpatient rehabilitation facility on the 19th hospital day. This report highlights the disease progression of COVID-19 in a pregnant woman, the clinical challenges in the critical care aspect of patient management, and the proposed multidisciplinary strategies utilizing an algorithmic approach to optimize maternal and neonatal outcomes.
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PMID:Severe COVID-19 in Third Trimester Pregnancy: Multidisciplinary Approach. 3308 63