Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0000737 (
abdominal pain
)
31,184
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A gratifying clinical response obtained in the setting of bilateral orbital metastases from renal neuroendocrine tumor is reported.
Methods:
A 53-y-old man diagnosed with renal neuroendocrine tumor (
MIB1
index, 4%), with symptoms of skeletal and
abdominal pain
, proptosis, and a decrease in vision of the left eye, was found to harbor bilateral orbital soft-tissue lesions on
68
Ga-DOTATATE PET/CT and MRI in addition to widespread metastatic skeletal lesions and metastatic lymph nodal disease. Despite radiotherapy to the left eye (20 Gy) and long-acting octreotide therapy for 18 mo, his symptoms worsened, with an increase in serum chromogranin A level, and he was considered for
177
Lu-DOTATATE peptide receptor radionuclide therapy (PRRT).
Results:
There was a significant improvement in skeletal pain, proptosis, and vision after 4 cycles of PRRT (cumulative dose of 22.2 GBq), stable disease on scanning, and a decrease in serum chromogranin A (from 150 to 36.39 ng/mL), with progression-free survival at 18 mo.
Conclusion:
PRRT through theranostic application of
68
Ga/
177
Lu-DOTATATE was thus helpful in this uncommon clinical setting.
...
PMID:Bilateral Orbital Soft-Tissue Metastases from Renal Neuroendocrine Tumor: Successful Theranostic Application of
68
Ga/
177
Lu-DOTATATE with Improvement of Vision. 3013 84
