Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000737 (abdominal pain)
31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ischemic colitis is typically limited to elderly patients who have concomitant disorders such as cardiovascular disease and chronic renal failure, but rarely affects a young person. The patient was an 18-year-old Japanese female who started dieting to obtain a slim figure three months before admission and presented with a two-month history of constipation and a sudden onset of lower abdominal pain and bloody diarrhea. She underwent colonoscopy, which revealed edema, hemorrhages, and several longitudinal shallow ulcers in the descending colon. Stool and blood culture results were negative for pathogens. She improved rapidly within five days without any specific therapies except intravenous hydration and anticholinergic agents, under the diagnosis of ischemic colitis. In this case constipation and dehydration associated with dieting seemed to be responsible for the development of ischemic colitis. We recommend that ischemic colitis should be included in the differential diagnosis of colitis with bleeding, even in patients younger than age 20 who do not have any predisposing factors.
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PMID:Ischemic colitis caused by strict dieting in an 18-year-old female: report of a case. 1206 8

Mr ST, a caucasian man aged 31 years, presented to hospital with weakness of his arms and legs. He felt unable to cope at home. Six weeks earlier, he sustained burns to his right hand, which occurred while trying to remove the radiator cap from his car. A review of hospital records revealed a history of hypertrophic cardiomyopathy, androgenic alopecia and abdominal pain, for which he had visited the cardiology, dermatology and gastroenterology departments respectively. Examination disclosed a slim male with frontal alopecia and wasted facial and proximal limb muscles. Reflexes were preserved, sensation intact. Notably, hand grip relaxation was delayed (myotonia). Haematological and biochemistry tests were unremarkable. Left ventricular hypertrophy and lateral T wave inversion were present on the electrocardiogram.
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PMID:A failure to relax. 1792 9

Peroral direct cholangioscopy (PDCS) is endoscopic method for diagnosis in the common bile duct (CBD) utilizing an ultra-slim upper endoscope. Clinical utility and problem of this method were investigated in ten patients who had stenosis or obstruction in the CBD with stones or a tumor. Scope shaft had to become the form of a U loop by counterclockwise rotation, to advance the scope in the direction of intrahepatic bile duct. As for one case, although the scope was formed alpha loop without U loop, direct observation of total CBC was possible. Large working channel of the endoscope could take adequate tissue sample by large biopsy forceps. Electrohydraulic lithotripsy and stone extraction with a basket could be accomplished easily and safely by direct visualization with a clear image. Pneumobilia was noted in all cases with insertion of PDCS. Although the abdominal pain and pyrexia with regard to PDCS did not occur, transient leukocytosis was noted.
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PMID:[Peroral direct cholangioscopy for diagnosis and treatment]. 1798 10

The aim of this study was to evaluate a low-dose CT with oral contrast medium (LDCT) for the diagnosis of acute appendicitis and compare its performance with standard-dose i.v. contrast-enhanced CT (standard CT) according to patients' BMIs. Eighty-six consecutive patients admitted with suspicion of acute appendicitis underwent LDCT (30 mAs), followed by standard CT (180 mAs). Both examinations were reviewed by two experienced radiologists for direct and indirect signs of appendicitis. Clinical and surgical follow-up was considered as the reference standard. Appendicitis was confirmed by surgery in 37 (43%) of the 86 patients. Twenty-nine (34%) patients eventually had an alternative discharge diagnosis to explain their abdominal pain. Clinical and biological follow-up was uneventful in 20 (23%) patients. LDCT and standard CT had the same sensitivity (100%, 33/33) and specificity (98%, 45/46) to diagnose appendicitis in patients with a body mass index (BMI) >or= 18.5. In slim patients (BMI<18.5), sensitivity to diagnose appendicitis was 50% (2/4) for LDCT and 100% (4/4) for standard CT, while specificity was identical for both techniques (67%, 2/3). LDCT may play a role in the diagnostic workup of patients with a BMI >or= 18.5.
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PMID:Evaluation of a low-dose CT protocol with oral contrast for assessment of acute appendicitis. 1879 75

A 13 year-old girl was admitted to hospital with abdominal pain and weight gain. The physical examination showed pronounced abdominal distension, but slim extremities. A magnetic resonance imaging scan revealed a left cystic ovarian tumour. The ovarian tumour was removed and the weight turned out to be 10.3 kg. Pathology showed a borderline mucinous cystadenoma. Ovarian tumours represent less than 2% of all tumours in girls under the age of 16. In this age group 50% of the ovarian tumours are neoplastic and 60% derive from the surface epithelia of the ovary.
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PMID:[A 10-kg ovarian mucinous cystadenoma in a 13 year-old girl]. 2254 60

Intraductal papillary mucinous neoplasm (IPMN) of the bile duct is still rare and not yet understood despite of its increased incidence and similar clinicopathologic characteristics compared with IPMN of the pancreas. The fistula formation into other organs can occur in IPMN, especially the pancreatic type. To our knowledge, only two cases of IPMN of the bile duct with a choledochoduodenal fistula were reported and we have recently experienced a case of IPMN of the bile duct penetrating into two neighboring organs of the stomach and duodenum presenting with abdominal pain and jaundice. Endoscopy showed thick mucin extruding from two openings of the fistulas. Endoscopic suction of thick mucin using direct peroral cholangioscopy with ultra-slim endoscope through choledochoduodenal fistula was very difficult and ineffective because of very thick mucin and next endoscopic suction through the stent after prior insertion of biliary metal stent into choledochogastric fistula also failed. Pathologic specimen obtained from the proximal portion of the choledochogastric fistula near left intrahepatic bile duct through the metal stent showed a low grade adenoma. The patient declined the surgical treatment due to her old age and her abdominal pain with jaundice was improved after percutaneous transhepatic biliary drainage with the irrigation of N-acetylcysteine three times daily for 10 d.
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PMID:Intraductal papillary mucinous neoplasm of the bile duct with gastric and duodenal fistulas. 2503 93

A mentally ill 46-year-old woman was admitted to our hospital because of a self-inflicted stab wound to the abdomen. Diagnostic laparoscopy was performed and the peritoneum was found to be intact. She was discharged in good physical health the next day. Local wound exploration could not be performed because of the slim stab wound. Conservative treatment with 12-24 hours of in hospital-observation could be an option, but since the patient presented with abdominal pain, surgery was the treatment of choice in this case.
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PMID:[Self-inflicted penetrating stab wound in mentally unstable patient - a clinical approach]. 2650 41