Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 42-year-old Thai man from central Thailand came to Ramathibodi Hospital with the complaint of abdominal pain. Physical examination revealed localized tenderness in the right lower quadrant. The clinical impression was acute appendicitis and an operation was performed, revealing a large mass in the cecum. A right hemicolectomy was done for what was thought to be a carcinoma of the colon. The resected colon showed subserosal thickening on the antimesenteric side of the ascending colon with a constricted area at the middle portion. An immature adult Gnathostoma spinigerum was identified in the thickened subserosa of the cecum. Microscopic examination of the involved bowel showed a heavy infiltration of eosinophils, fibroblasts and histiocytes, and mild to moderate edema. The findings were consistent with eosinophilic granuloma of the gastrointestinal tract, and the presence of the parasite in the affected bowel suggested that it was the etiologic agent.
 ...
PMID:Gnathostomiasis, a possible etiologic agent of eosinophilic granuloma of the gastrointestinal tract. 43 14

A case of pancreatic ascites is reported and compared with 55 previously reported cases. A 42-year-old black male chronic alcoholic presenting with abdominal pain was found at operation to have chronic pancreatitis with no pseudocyst formation or overt duct disruption, in contrast to the majority of cases reported. The diagnosis and differentiation from cirrhosis of the liver were based on the operative findings, elevated serum amylase level, ascitic fluid amylase value, and protein content. Surgical exploration alone has proven beneficial--the patient has done well in the past 2 years with no recurrence of the ascites and continued weight gain. The clinical course was compatible with pancreatitis although the radiographic and angiographic studies were not diagnostic. It is suggested that the clinical entity of pancreatic ascites occurs more often than reported and a workup for it should be done even in the face of unconvincing radiographic and angiographic evidence.
 ...
PMID:Pancreatic ascites. A case report and review of the literature. 120 11

A 42-year-old man with fever, right lower quadrant abdominal pain, and occasional rectal bleeding was diagnosed as having Crohn's disease. He was started on sulfasalazine (Azulfidine) therapy, and a generalized rash subsequently developed. When laboratory data indicated possible sulfasalazine hepatotoxicity, use of the drug was discontinued. Symptoms continued to worsen, however, and the patient died of fulminant hepatic necrosis. Comparison with similar cases showed that a hypersensitivity reaction was probably responsible for the liver damage, with a latent period that made recognition difficult. Thus, while fulminant hepatic necrosis is rare, this possibility must always be considered by the clinician when prescribing and monitoring therapy with sulfasalazine.
 ...
PMID:Hepatotoxicity after treatment with sulfasalazine. 287 49

A 42-year-old American male researcher contracted schistosomiasis from environmental sources in the course of his observations on human behavior in Upper Egypt. After a long asymptomatic period, he developed various symptoms and Schistosoma haematobium was found in a urine examination. After treatment with Metrifonate, urine examination became negative. However, abdominal pain persisted and most diagnostic tests were negative. Colonoscopic examination and biopsy of the mucosa revealed schistosomiasis. Treatment with Praziquantel was thoroughly effective in clearing the persistent Schistosoma haematobium infection. It is necessary to maintain a high index of suspicion in cases of potential schistosomiasis. The availability of nontoxic treatment is discussed.
 ...
PMID:Schistosomiasis in an American medical investigator. 309 17

A 42-year-old woman presented with abdominal pain and diarrhea. Small bowel x-rays and endoscopy revealed a diffuse, infiltrating lesion of the small intestine, which on biopsy proved to be melanoma diffusely infiltrating the lamina propria. Because of marked hypoalbuminemia, protein-losing enteropathy was suspected. This is an unusual case, because melanoma of the small intestine usually does not produce diffuse involvement.
 ...
PMID:An unusual case of malignant melanoma of the small intestine. 647 98

Nontraumatic renal subcapsular hematoma is an uncommon but not rare clinical entity. If a small renal cell carcinoma is the cause of the hematoma, the carcinoma can hardly be diagnosed on the basis of conventional roentgenographic findings. Computerized tomography provides a noninvasive means of visualizing the hematoma and renal tumor, and of understanding their extent, location and relationship to renal parenchyma. A 42-year-old female, whose complaint was right abdominal pain and vomiting, was admitted to our hospital and a right renal subcapsular hematoma was demonstrated by computerized tomography. She was in good general condition, and renal malignant tumor was not demonstrated by computerized tomography, conventional roentgenographic examinations or ultrasonography. Her clinical course was not eventful . A brief review of clinical diagnosis and management of this disease are made.
 ...
PMID:[Computerized tomographic demonstration of a nontraumatic renal subcapsular hematoma]. 667 12

A 42-year-old male was hospitalized in the surgical ward for abdominal pain due to stenosis of the splenic flexure of the colon and abscess around the stenosis. After segmental colectomy, the patient received intravenous continuous infusion of trimetaphan (Arfonad) to control his blood pressure. Twenty hours later, he developed bradycardia and hypotension followed by syncope. An electrocardiogram revealed marked prolongation of the QT interval and a prominent U wave associated with sinus bradycardia and/or sinus pause with junctional rhythm. Torsades de pointes type polymorphic ventricular tachycardia was the cause of the syncope, which appeared to be pause-dependent long QT syndrome caused by the ganglionic blocking action of trimetaphan in the presence of a hyperadrenergic state.
 ...
PMID:[A case of torsades de pointes probably caused by trimetaphan intoxication]. 820 40

Renal artery infarction is a very rare complication in patients with systemic lupus erythematosus (SLE), even in patients with antiphospholipid syndrome which often causes thromboembolism: Renal infarctions have only been reported in 4 SLE patients with antiphospholipid antibodies (aPL). Here we report a case of SLE without aPL who accompanied by renal and cerebral infarctions. A 42-year old Japanese woman with 8 year history of SLE manifested by arthralgia, central nervous system symptoms, positive-antinuclear and anti-DNA antibodies was admitted to our hospital for the treatment of progressive lupus nephritis. Physical examinations revealed hypertension (130-160/80-110 mmHg) without pitting pretibial edema. Laboratory evaluations showed proteinuria (3.7 g/day), normal serum creatinine level (0.9 mg/dl), low serum albumin level (2.3 g/dl) and high cholesterol level (317 mg/dl). Old cerebral infarctions were recognized by magnetic resonance imaging. However, hematological and immunological studies revealed that this case has neither a prolonged activated partial thromboplastin time, lupus anticoagulant nor anticardiolipin antibodies. Prednisolone was increased from 30 mg/every other day to 30 mg/day, and oral azathioprine, 50 mg/day, was started for the treatment of lupus nephritis. On the 11th day, she suddenly complained severe abdominal pain, which gradually localized on the right side. Computed tomography of the kidney suggested right renal infarctions, and arteriography of right renal artery confirmed both an obstruction of the ventral branch and a narrowing of the dorsal branch of right renal artery. No intra-cardiac thrombus was demonstrated by echocardiography. Following to the treatment with fibrinolytic agent and anticoagulant, her symptoms have improved.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Renal and cerebral infarctions in a patient with systemic lupus erythematosus without antiphospholipid antibodies]. 823 16

Giant hepatocytes are commonly found in several neonatal and infantile liver diseases, but are rarely found in adult liver disease. A 42 year old white woman presented with a five month history of paraesthesia and numbness of both the upper and lower limbs and with vague abdominal pain. Abnormal liver function was noted on routine screening. Ultrasound scan of the abdomen showed gallstones; barium enema, ERCP and computed tomography scan were all normal. IgG antibodies to double stranded DNA were present at a titre of 40 units. Anti-cardiolipin antibodies, anti-mitochondrial antibodies and rheumatoid factor were not detected. Serology for hepatitis A, B, C, and paramyxoviruses was negative, as was the Paul Bunnell test. A clinical diagnosis of systemic lupus erythematosus (SLE) with an axonal sensory polyneuropathy was made, the latter confirmed on biopsy of the sural nerve. Giant cells were noted on liver biopsy. The patient was treated with corticosteroids; liver function had improved after two years of follow up. When extensive giant cell transformation is noted on liver biopsy, particularly when neuropathy is also a feature, the possibility of an association with SLE should be considered.
 ...
PMID:Giant cell hepatitis associated with systemic lupus erythematosus. 865 94

A 42-year-old white man had headache, fever, chills, abdominal pain, nausea and vomiting, night sweats, and dark urine for 3 days before admission; he had history of a tick bite 6 weeks earlier. Progressive systemic deterioration, heralded by progressive hepatosplenomegaly and pancytopenia, occurred despite doxycycline therapy. Subsequent recovery was preceded by progressive resolution of hepatosplenomegaly. Progressive hepatosplenomegaly has not been previously reported in association with systemic monocytic ehrlichiosis.
 ...
PMID:Systemic ehrlichiosis presenting as progressive hepatosplenomegaly. 919 48


1 2 3 4 5 6 7 8 9 Next >>