Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In England, both a mother and her daughter either suffered their first attacks of hereditary angioedema around puberty or the disease worsened around puberty when estrogen levels were rising. The main symptoms included sudden swelling and reddening of the skin. The mother is the first reported case of exacerbated symptoms of hereditary angioedema occurring premenstrually. Use of a combined oral contraceptive (OC) (Femodene) exacerbated the daughter's symptoms. Symptoms improved after stopping the OC. The mother also experienced more severe and frequent attacks of symptoms while taking an OC. Acute attacks with abdominal pain diminished after OC cessation, but she still suffered edema and reddening of the skin. The daughter's C1 esterase inhibitor level was down to only .06 g/L in July 1988 and .09 g/L in December 1989. The mother's C1 esterase inhibitor level was 25% of normal levels. When another daughter was 4 years old she had a C1 esterase inhibitor level 25% of the normal range. The level of the same younger daughter in June 1990 was 22% of the normal range. The oldest daughter was treated with Stanozolol and the mother with Danazol. The youngest daughter received Terfenidine and experienced no symptoms thereafter. Unlike other women with hereditary angioedema, the mother did not experience worsening of symptoms during pregnancy. Danazol, a derivative of 17-alpha-ethinyl testosterone, significantly reduces plasma estradiol levels. It can increase C1 esterase inhibitor levels 3 to 4.5 times pretreatment levels and C4 levels 15 times. These cases and the literature led the dermatologists to recommend that clinicians should not administer estrogen-containing contraceptives to women known to have hereditary angioedema. It appears that progesterone-only contraceptives induce attacks of nonhereditary forms of angioedema. Much more research on the safety of hormonally-exacerbated, hereditary angioedema needs to be done.
 ...
PMID:Hormonally exacerbated hereditary angioedema. 144 91

A 33-yr-old Japanese woman, married, no parity, was treated for endometriosis. Danazol 400 mg a day was initiated on September 25, 1986, for 21 consecutive days. She became severely constipated and had left lower abdominal colic pain. Five days later, she had to be admitted to the hospital, because she had had no bowel movements for 12 days and the abdominal pain was severe. On the day after admission, she had frequent painful bowel movements. The stool was blood-tinged, but pathogenic bacteria were nil. Ischemic colitis of the stricture type was identified. She was treated with hyperalimentation and anticholinergic agents. At 3 months and 5 days after discharge from hospital, danazol 400 mg per day was readministered, and 11 days later, the patient again became constipated and complained of the same pain in the left flank. We consider that danazol-induced constipation played a role in the onset of the ischemic colitis.
 ...
PMID:Ischemic colitis in a 33-year-old woman on danazol treatment for endometriosis. 319 51

Our study objective was to describe the appearance, stage, and treatment of endometriosis in adolescents undergoing laparoscopic treatment of severe dysmenorrhea and endometriosis. We designed a retrospective analysis of adolescents with endometriosis whose primary symptom was severe dysmenorrhea. We studied patients in a private practice associated with a residency program. Forty-nine adolescents with histologically confirmed endometriosis underwent laparoscopy. Thirty-six of these patients (mean age, 16.6 +/- 1.4 years; range, 13-20 years) presented with severe dysmenorrhea in a non-emergency state and were refractory to prior therapy. All patients underwent laparoscopic surgery. We classified endometriosis implants as typical implants, red lesions, and occult lesions in thirty-six adolescents. We excised infiltrating lesions (defined as implants penetrating greater than 3-5 mm) and vaporized or coagulated superficial lesions (defined as surface implants or those penetrating < 3 mm). All adolescents underwent postsurgical ovulation suppression with a daily birth control pill. The need for reoperation at any time or the use of GnRH analogs, Danazol, or large doses of progestins served to indicate treatment failure. The presence or absence of red lesions was recorded in this group and compared to the presence or absence of such lesions in an older population of patients undergoing definitive therapy for endometriosis during the same time period. Our results showed that red lesions are the predominant implant type in adolescents. Adolescents with cyclic pain and those who complain of abdominal pain, nausea, constipation, and diarrhea, during menses had the largest proportion of red lesions.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Clinical characteristics of adolescent endometriosis. 839 47

Hereditary angioedema is caused by a defect in C1 inhibitor activity (C1INH). Its occurrence is rare and it is associated with an autosomal dominant mode of inheritance. We describe seven patients (4M:3F), age from 12 to 50 years old, who are affected by hereditary angioedema; four of them belong to the same family. The main clinical manifestations were: angioedema of face, hands and feet (6/7) and abdominal pain (2/7). No triggering factors were associated with symptoms in 4/7 patients and trauma (2/7) and menses (1/7) were reported in the other three ones. One patient was submitted to laparotomy for partial intestinal resection, before diagnosis. Laboratory complement analysis revealed the absence of hemolytic function of complement, reduced C4 (6/7) and low C1INH levels. All patients received Danazol (100 mg/day) with clinical control. Hereditary angioedema has to be considered in the differential diagnosis of angioedema, since an early diagnosis of this immunodeficiency, leading to specific treatment in order to decrease the complications.
 ...
PMID:[Hereditary angioedema: clinical and laboratory aspects of 7 cases]. 965 39

We report on an angioedema patient with a genetic defect in complement 1 inhibitor, manifesting migraine-like episodes of headache, effective prophylaxis with Danazol, and triptan for a treatment of acute clinical episode. The patient was 44-yr-old Korean man with abdominal pain and headache, who was brought into the Emergency Department of Seoul National University Hospital, Seoul. He suffered from frequent attacks of migraine-like headache (3-7 per month), pulsating in nature associated with nausea. Severities were aggravated by activity and his headache had shown recent progression with abdominal pain. No remarkable findings were observed on radiologic examination, brain magnetic resonance images and intracranial and extracranial magnetic resonance angiography. Danazol 200 mg every other day was subsequently used. Following administration of Danazol, symptoms showed improvement and the patient was discharged. While taking Danazol, the migraine-like episodes appeared to be prevented for about 2 yr. At the eighth month, he suffered a moderate degree of migraine-like headache; however, administration of naratriptan 2.5 mg resolved his problem. A case of genetic defect of C1-INH deficiency presented with headache episodes, and was controlled by Danazol and triptan. It suggests that pathogenic mechanism of headache in hereditary angioedema may be mediated by the neurogenic inflammatory-like physiology of migraine.
 ...
PMID:Migraine-like headache in a patient with complement 1 inhibitor deficient hereditary angioedema. 2221 24