Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Non-steroidal anti-inflammatory drugs (NSAIDs) may adversely affect the colon, either by causing a non-specific colitis or by exacerbating a preexisting colonic disease. Patients with NSAID-induced colitis present with bloody diarrhoea, weight loss, iron deficiency anaemia and sometimes abdominal pain. Colonoscopy may be normal or may show inflammation, ulceration or diaphragm-like stricture. Histology often concludes to non-specific colitis. NSAIDs may cause perforation or bleeding of colonic diverticula, may cause relapse to inflammatory bowel disease and may exacerbate bleeding of colonic angiodysplasia. Pathogenesis of NSAID-induced colitis is still controversial. Local and/or systemic effects of NSAIDs on mucosal cells might lead to an increased intestinal permeability, which is a prerequisite for colitis. Treatment of NSAID-induced colitis should be to discontinue the drug, or at least, to reduce the dose as much as possible. Sulphasalazine and Metronidazole have been successfully used in few studies. Surgery is often indicated in case of life threatening complications or untractable symptoms.
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PMID:Non-steroidal anti-inflammatory drug-induced colitis. 873 36

The onset of ulcerative colitis is characterized by diarrhea and bleeding, while granulomatous ileocolitis may be similar or more obscure with abdominal pain, bowel obstruction, loss of weight, iritis, arthritis or hypoalbuminemia. The diagnosis in ulcerative colitis is made by sigmoidoscopy and barium enema, while small bowel follow through is necessary in ileocolitis. Ulcerative colitis is treated by adrenocorticosteroids as retention enemas when limited to the left colon, intravenous ACTH or steroids in severe pancolitis and oral steroids in others. Sulphasalazine is used in addition to steroids in acute cases and as maintenance to prevent exacerbations. Proctocolectomy is indicated in those with severe disease with complications not responding to steroids. The treatment of Crohn's disease is similar but complicated by small bowel involvement and recurrence after surgery.
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PMID:Diagnosis and management of inflammatory bowel disease. 2130 11