Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gastroesophageal reflux disease (GERD) is a common cause of chronic cough, heartburn, epigastric or retrosternal discomfort, chest pain and abdominal pain or esophagitis. Our patients with OSAS seldom manifest GERD symptoms. We suspected that obesity and high pressure in abdominal cavity may induce acid gastroesophageal reflux in these patients. The aim of the study was to test the hypothesis that obesity, cigarettes smoking or ventilatory and gas exchange abnormalities provoke GERD. We studied 21 consecutive patients with severe OSAS (mean AHI 44.9+/-23.8) before CPAP treatment, all without GERD clinical symptoms. Standard polysomnography, gastroscopy and 24-h oesophageal pH monitoring was performed. There were 6 females, 15 males, mean age 57+/-9 years, mean BMI 38+/-6 kg/m2. All patients presented with normal spirometric and gas exchange values (mean VC 3.64+/-1.23 1, 90% of normal, mean FEV1 2.61+/-0.95 1, 83% of normal, mean FEV1%VC 72%, mean PaO2 68.1+/-7.7 mmHg, mean PaCO2 40.8+/-5.8 mmHg, mean pH 7.42+/-0.02). GERD was diagnosed in 14 patients. Patients with GERD were younger, more often were cigarettes smokers (5/14). We did not fi nd statistically significant differences between severity of OSAS, BMI, ventilatory or gas exchange parameters and GERD.
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PMID:[Gastroesophageal reflux disease (GERD) in patients with obstructive sleep apnoea syndrome (OSAS)]. 1742 43

Congenital diaphragmatic hernias occur through embryologic defects in the diaphragm. A subset of adults (5-10 %) may present with a congenital hernia undetected during childhood. It requires surgery because of the risk of incarceration. An old lady having vomiting, upper abdominal pain, dyspnoea and retrosternal discomfort was diagnosed with the presence of a large left-sided Bochdalek diaphragmatic hernia and a hypoplastic lung. Laparoscopic repair was performed successfully after adequate preparation. The patient had postoperative respiratory difficulty and needed mechanical ventilation and intensive care for 5 days. She was discharged 8th POD. There was no recurrence in 32 months follow-up, though the hypoplastic left lung never recovered. Laparoscopy is proving to be more beneficial than laparotomy or thoracotomy. The use of a mesh further strengthens the defect and reduces chance of recurrence.
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PMID:Laparoscopic surgery for giant adult bochdalek diaphragmatic hernia: combined suturing and polypropylene mesh repair. 1778 33

Infectious esophagitis may be caused by fungal, viral, bacterial or even parasitic agents. Risk factors include antibiotics and steroids use, chemotherapy and/or radiation therapy, malignancies and immunodeficiency syndromes including acquired immunodeficiency syndrome. Acute onset of symptoms such as dysphagia and odynophagia is typical. It can coexist with heartburn, retrosternal discomfort, nausea and vomiting. Abdominal pain, anorexia, weight loss and even cough are present sometimes. Infectious esophagitis is predominantly caused by Candida species. Other important causes include cytomegalovirus and herpes simplex virus infection.
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PMID:Etiology, diagnosis and treatment of infectious esophagitis. 2486 80