Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The goal of this study was to clarify the subjective symptoms closely related to yusho by examining the relationship between the amount of PCB-contaminated rice oil ingested by patients and the subjective symptoms recorded on their questionnaires. The amount of PCB-contaminated rice oil consumed by the patients was obtained by interviewing the housewife in each yusho family. Individual consumption of the oil was estimated by taking into account age, sex and the number of meals at home. In 1970, 46 patients were available for analysis, and in 1971, 33 patients were available. Among 12 subjective symptoms studied, numbness of the limbs, coughing, expectoration, and the sensation of "elevated" teeth were considered to show a dose-response relationship, which suggests that these subjective symptoms are closely related to yusho. Consistent high rates of complaints of general fatigue and eye discharge were considered possibly to be connected with yusho, although no dose-response relationships have been determined. Other subjective symptoms, such as fever, headache, dizziness, abdominal pain, swelling in the joints, changes in menstruation, and loss of hair failed to show consistent dose-response relationships. It should be noted, however, that for these symptoms which failed to show dose-response relationships, it is impossible to deny a causal relationship.
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PMID:Relationship between the amount of rice oil ingested by patients with yusho and their subjective symptoms. 392 63

Although the incidence of occupational and adult lead poisoning has declined, the problem still exists. It often goes unrecognized for long periods because of a low index of suspicion compounded by incomplete surveillance of risk populations. Abdominal pain, fatigue and arthralgia are the most frequent symptoms. Anemia, basophilic stippling of red blood cells and hyperuricemia are the most common clues. Diagnosis is based on blood lead levels. Chelation by calcium disodium edetate, followed by oral penicillamine, is the standard treatment.
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PMID:Adult lead poisoning. 393 45

A standardized clinical, laboratory, and histological assessment was carried out on 85 patients with primary biliary cirrhosis within 1 year of developing symptoms. Presenting symptoms included pruritus (n = 30), jaundice (n = 9), variceal bleeding (n = 6), ascites (n = 5), fatigue (n = 4), and abdominal pain (n = 4). Ten patients had symptoms not immediately suggestive of hepatic etiology and a further 17 were asymptomatic, the diagnosis being made fortuitously. Eighty four percent were not incapacitated and 52 were anicteric. Less than half were pigmented, 22% had xanthoma, and only 12% were deeply jaundiced. In contrast, all had significant laboratory abnormalities with alkaline phosphatase activity greater than 400 IU/L in 60% and IgM greater than 2.5 g/L in 75%. Mitochondrial antibody was detectable in 83% with a titer greater than 1:160 in 70%. Cirrhosis was present in 24 patients, nine of whom were anicteric and a further 11 had fibrosis or scarring.
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PMID:Early features of primary biliary cirrhosis: an analysis of 85 patients. 400 76

The clinical features of 150 consecutive patients with irritable bowel syndrome are reported. All patients were referred to a private practice. There was a marked female preponderance and a wide range of ages. Diarrhoea was predominant in 61,3%. The common symptoms were altered bowel habit, abdominal pain, emotional disturbance, flatulence and distension. Fatigue, weight loss, upper gastrointestinal symptoms, backache and urinary symptoms were frequent. The rectum showed nonspecific loss of vascular pattern, oedema and congestion in 11,4% of patients, but this was readily distinguished from inflammatory bowel disease on histological examination. The incidence of non-smokers in the group was 78,1%. The overall appendicectomy rate was 34%, and 65% of the 92 women had had gynaecological operations. A positive diagnosis was made on a typical history and simple basic investigations. More extensive investigations were required for those patients with markers of organic disease, but these yielded few associated lesions.
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PMID:The irritable bowel syndrome--a study from private practice. 403 10

This study evaluated characteristics of symptoms, their perceived cause, and delay in seeking a diagnosis associated with stage, grade, and histologic features of disease at diagnosis among incident cancer cases of the ovary (N = 83) identified in the Iowa National Cancer Institute-Surveillance, Epidemiology, and End Results population-based cancer registry. Contrary to clinical impressions, most early-stage cancers produced symptoms and were more likely than late-stage cancers to cause fatigue and urination problems; however, only irregular menstrual cycles were more likely to convince these patients with early-stage cancers to seek a diagnosis. Late-stage cases were most often accompanied by abdominal pain and swelling, but only pain was likely to convince women to seek a diagnosis. There was no association between delay, perceived cause, or seriousness of symptoms with stage of disease at diagnosis. Women, particularly those with a medical history of high risk factors, should be made aware that apparently benign disease symptoms are characteristic of early ovarian cancer and that this tumor can be found early if they seek medical attention immediately.
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PMID:The effects of symptoms and delay in seeking diagnosis on stage of disease at diagnosis among women with cancers of the ovary. 405 47

The authors, who reported a case of ovarian pregnancy a year ago, report a second case. The diagnosis was difficult to make because of a typical symptoms. A healthy 27-year-old woman was referred to the Kantonsspital, Liestal, Switzerland, on February 16, 1973. She had been wearing a Lippes loop C since 1970. The patient's last menstruation was on December 11, 1972. She complained of left lower abdominal pain in the middle of January, and a pregnancy test carried out on February 8, 1973, was positive 2 days after the patient received 1 ampule of Lutovocyclin forte. On admission, however, the pregnancy test was negative. At laparoscopy, the left ovary was yellowtinged, partly cystic, and contained blood. It was interpreted as a corpus luteum. After laparoscopy, the bleeding which had occurred before stopped, but the patient still complained of left lower abdominal pain and tiredness. Laparotomy was performed. The left ovary was partly resected, and it was found to contain a blood-filled cyst. The histological diagnosis was recent ovarian pregnancy. The postoperative phase was uneventful.
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PMID:Another case of ovarian pregnancy in a patient with IUD. 448 22

The relationship between symptoms reported during the first two cycles of oral contraceptive use and subsequent discontinuation was studied using data from a comparative clinical trial of two oral contraceptives (standard dose and low dose) in Sri Lanka. Among 24 symptoms considered, the most commonly reported were headache, nausea, irritability, dizziness, tiredness, intermenstrual spotting/bleeding, backache, abdominal pain, vomiting, and hair loss. Headache, nausea, vomiting, and dizziness were closely associated with each other and strongly predictive of discontinuation for both drugs. No other symptoms were consistently associated with each other or with subsequent discontinuation. Intermenstrual spotting/bleeding was associated with later discontinuation of the standard dose preparation, but not the lower dose preparation.
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PMID:Early symptoms and discontinuation among users of oral contraceptives in Sri Lanka. 639 60

Within a three-year period 712 patients with Campylobacter jejuni infection were diagnosed at our laboratory in Helsinki and 524 (72%) were treated as outpatients. More than half (57%) of the patients became infected when abroad, chiefly during holiday trips in the Mediterranean and in East European countries. The risk of acquiring infection was about 250 times greater abroad than in Finland, and it differed considerably from country to country, being highest in Morocco and Tunisia. Among domestic cases the incidence of infection was significantly higher (p less than 0.001) during the summer and autumn months than during winter or spring. Animal contact prior to infection was reported in 59% of domestic and 31% of imported cases, and previous consumption of poultry in 28% and 42% of those from whom information was obtained. Besides diarrhoea (98%), the main symptoms included abdominal pain (87%), fatigue (81%), fever (78%), malaise (70%) and headache (51%). Arthralgia was observed in 19% and arthritis in 2% of patients. The mean duration of diarrhoea was 10.8 days, of fever 2.8 days.
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PMID:Infection due to Campylobacter jejuni: a report of 524 outpatients. 646 63

Abdominal epilepsy is an uncommon cause for abdominal pain in children and adults. Although its abdominal symptoms may be similar to those of the irritable bowel syndrome, it may be distinguished from the latter condition by the presence of altered consciousness during some of the attacks, a tendency toward tiredness after an attack, and by an abnormal EEG. Abdominal epilepsy is usually treated with anticonvulsant medication. This unusual cause for abdominal pain should be considered in patients with the appropriate abdominal symptoms who do not respond to the usual symptomatic therapy.
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PMID:Abdominal epilepsy: an unusual cause of recurrent abdominal pain. 647 97

In the present multicentre double blind study of 428 patients with the irritable bowel syndrome a significant beneficial effect was found on abdominal pain, nausea, sleeplessness and depression by using 50 mg of the antidepressive drug, trimipramine, in the evening, as well as 10 mg three times daily. A significant effect was also recorded for the total score of wellbeing during the treatment period of 6 weeks. No side effects were recorded except tiredness in the morning in some patients during the first two weeks.
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PMID:Psychopharmacologic drugs in the treatment of the irritable bowel syndrome. A double blind study of the effect of trimipramine. 652 68


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