Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Metanephric adenoma of the kidney is rare. We report 2 cases of metanephric adenoma with massive hemorrhage and necrosis. Case 1, a 42-year-old Japanese woman, complained of abdominal pain. Case 2, a 41-year-old Japanese woman, complained of fever and lumbago. They underwent nephrectomy. The cut surface was solid and yellow with massive hemorrhage and necrosis. These tumors showed packed tubular and glomeruloid patterns. The tumor cells were uniform and small, with uniform, oval, and hyperchromatic nuclei and scant cytoplasm, and showed reactivity for cytokeratin, vimentin, and CD 57. The MIB-1 indexes were up to 0.63%. The DNA ploidy pattern was diploid. The tumor cells formed small tubular structures with lumina and microvilli. These features suggested that metanephric adenoma is a benign tumor of an immature epithelial nature.
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PMID:Metanephric adenoma of the kidney with massive hemorrhage and necrosis: immunohistochemical, ultrastructural, and flow cytometric studies. 1461 36

Metanephric adenomas are benign tumors frequently found post-mortem (from 7% to 22% of autopsies) which originate from distal tubules; they are generally small in dimensions (smaller than 1 cm) and located in the renal cortex. Etiology is unknown, even though they could be associated with smoke, tubular nephrosclerosis, dialysis. An endocrinal relationship was proposed, because of its more frequent incidence in female (2:1). Metanephric adenoma is an uncommon kind of renal adenoma with no malignant potentiality: from the clinical and diagnostic viewpoint its own greater importance depends on the probability of diagnostic misunderstanding with Wilms' tumor; furthermore its echographic, tomographic and arteriographic characteristics are often similar to small renal adenocarcinoma ones (100). Polycytemia is frequently associated to metanephric adenoma as paraneoplastic syndrome and, more rarely, abdominal mass, abdominal pain, hematuria and hypertension (140). The most important study on metanephric adenoma is the one realized by E.K. Mostofi, including 50 cases from the Department of Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, D.C., published in 1995; in this study half of findings was incidental; mean dimension of tumor about 5,5 cm and in 50% it could be seen a distinct capsule sourrounding the tumor (in the remaining cases the capsule was discontinuos or absent) (210). An important radiological characteristic is that metanephric adenomas are more frequent calcificated than other histotypes and, from the pathological viewpoint, the most important differential element seems to be the smaller dimensions of its cells with hyperchromatic nuclei in the absence or lack in mitotic activity and in the absence of chromosome aberrations. In the case of difficult histological diagnosis, cytogenetic and immunohistochemical analysis can be useful. In conclusion, because it is impossible to distinguish in the preoperatory between the metaneprhic adenomas and the other tumoral types on the bases of the symptoms, dimensions or radiographic appearance, it is mandatory to treat it as malignant eteroformations in a therapeutical strategy, when it is possible.
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PMID:Metanephric adenoma: case report and review of the literature. 1556 3

Metanephric adenoma is an extremely rare tumor of the kidney. The clinical and anatomic characteristics are not yet well defined, but it is currently considered to be a benign tumor with a good prognosis, although recently two metastatic cases have been reported. Around 50% of cases are incidental findings, and symptoms include polycythemia, abdominal pain, hematuria and palpable mass. The morphological characteristics are similar to those of Wilms' tumor, suggesting a common embryological precursor. We present here the youngest girl yet to be reported with a diagnosis of metanephric adenoma.
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PMID:Metanephric adenoma: a rare differential diagnosis of renal tumor in children. 1894 70

Metanephric adenoma (MA) of the kidney is a rare and frequently benign tumor with a favorable prognosis that is often diagnosed following surgical treatment. In the present study, a 54-year-old female patient presented with complaints of intermittent right-flank pain and anterior abdominal pain occurring over 2 years and sporadic gross hematuria occurring over 3 months. Ultrasonography and computerized tomography imaging revealed a neoplasm lesion localized in the right kidney. Successful open approach radical nephrectomy was performed and post-surgical histopathological examination verified the lesion as a MA of the kidney. Radical nephrectomy, cryoablation or radiofrequency may used to treat MA and a selective panel of immunostains, including WT1, EMA and AMACR, may be useful for diagnosis.
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PMID:A metanephric adenoma of the kidney associated with polycythemia: A case report. 2687 Feb 16