Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eosinophilic gastroenteritis is an uncommon cause of abdominal pain which may mimic other causes of acute abdominal pain and result in unnecessary laparotomy. In many cases clues to the diagnosis are available prior to surgery; however a high index of suspicion must be maintained if the condition is to be identified at presentation. Two cases are described followed by a review of the disease entity.
 ...
PMID:Eosinophilic gastroenteritis. 202 69

A review was undertaken of 220 case reports of eosinophilic gastroenteritis involving the gastrointestinal tract, with particular regard to its clinical presentation and management. The stomach was the single commonest site of involvement (43%), while 36% were found to have two or more sites of disease at the time of presentation. The most common presenting symptoms were episodic abdominal pain (77%) and diarrhoea (42%). A history of allergy was present in 52% of patients, while 8% reported aggravation of symptoms following the ingestion of certain foods. Two thirds of patients had reported symptoms of more than six months duration prior to diagnosis, while in 26%, five years or more had elapsed. Although surgical intervention was undertaken in 44% of patients at some stage in their management, the most successful mode of management was the institution of steroid therapy, where 90% reported rapid clinical improvement. There is no evidence that patients with eosinophilic gastroenteritis have a higher incidence of subsequent gastrointestinal malignancies.
 ...
PMID:Eosinophilic gastroenteritis. 207 46

Two patients suffering from eosinophilic gastroenteritis (EG) were treated with sodium cromoglycate (SCG). Before treatment they showed enteric and cutaneous symptoms, such as abdominal pain, nausea, vomiting, diarrhoea and recurrent urticaria and angioedema. The histological findings were a notable amount of eosinophilic infiltration in the lamina propria and gastric glands, a villous shortening and thickening and weak eosinophilic inflammation in the duodenum. The patients were treated with 300 mg SCG, 4 times daily, for 4/5 months. During treatment, the clinical symptoms disappeared and at the end of treatment a reduced inflammation with an almost complete decrease of eosinophilic infiltration was observed. The results provide evidence of SCG efficacy in the treatment of EG and suggest its employment as an alternative to the steroids commonly used in EG.
 ...
PMID:Sodium cromoglycate in the treatment of eosinophilic gastroenteritis. 210 47

The aim of this study was to evaluate the clinicopathological spectrum of eosinophilic gastroenteritis and identify possible difficulties in establishing the diagnosis. All patients with a diagnosis of eosinophilic gastroenteritis, defined by the presence of gastrointestinal symptoms and eosinophilic infiltration of the gut (38), or a radiological diagnosis with peripheral eosinophilia (two), were identified from the Mayo Clinic records; in none was there evidence of extraintestinal disease. Patients were divided into three groups according to the Klein classification: predominant mucosal (23), muscular (12), or subserosal disease (five). A fourth group of patients (10) for comparison had abdominal symptoms and unexplained peripheral eosinophilia but no proven eosinophilic infiltration of the gut. It was found that a history of allergy was reported by 20 of 40 patients with eosinophilic gastroenteritis. Peripheral eosinophilia was absent in nine of 40. The patients with subserosal disease were distinct from the other groups in presentation (abdominal bloating, ascites), higher eosinophil counts and in their dramatic responses to steroid therapy. Otherwise the patients were similar regarding demographic factors, presenting symptoms (abdominal pain, nausea, weight loss, diarrhoea), and laboratory parameters. The ESR was moderately raised in 10 of 40 patients. The disease may affect any area of the gastrointestinal tract; eosinophilic infiltration was documented in the oesophagus in one patient and in the colon in two cases. Endoscopic biopsies missed the diagnosis in five of 40 presumably because of patchy disease. Eosinophilic gastroenteritis should be considered in the differential diagnosis of unexplained gastrointestinal symptoms even in the absence of peripheral eosinophilia.
 ...
PMID:Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. 231 32

A 20-year-old woman is presented who had eosinophilic gastroenteritis of the muscularis and serosal type which involved the terminal ileum. The diagnosis was initially acute appendicitis, but clues to the correct diagnosis included the presence of malabsorption, protein-losing enteropathy, abdominal pain and ascites, and especially a history of recurrent bouts. Peripheral eosinophilia is found in most cases and biopsy, or a peritoneal tap when ascites is present, may demonstrate a predominantly eosinophilic infiltration. Radiographic findings include a rigid, open ileocecal valve. There is rapid response to corticosteroid therapy, but long term follow-up is required because the disease may run a chronic, relapsing course.
 ...
PMID:[Eosinophilic gastroenteritis]. 280 53

Eosinophilic gastroenteritis (EG) is an uncommon disorder, characterised by cramping abdominal pain, diarrhoea and vomiting and histologically by eosinophilic infiltration of bowel wall. We present a patient who developed EG during the course of a systemic, necrotising vasculitis, who became critically ill after failure of treatment with corticosteroids and cytotoxic drugs and responded only to oral sodium chromoglycate.
 ...
PMID:Near fatal eosinophilic gastroenteritis responding to oral sodium chromoglycate. 314 28

Eight years after the onset of bronchial asthma a 28-year-old woman fell ill with abdominal pain, diarrhoea and rapidly increasing ascites. Increased numbers of eosinophils in the protein-rich ascitic fluid and histologically demonstrated eosinophilic infiltration of the intestinal mucosa, together with the history and symptoms, established the diagnosis of eosinophilic gastroenteritis. The disease proved self-limiting without specific treatment. Within four years of first manifestations there were two short recurrences with rapid regression without specific treatment.
 ...
PMID:[Eosinophilic gastroenteritis with ascites]. 370 80

A 41-year-old female with intermittent abdominal pain and diarrhea for a period of three years was found to have eosinophilic enteritis. The patient has had neither a history of atopy nor peripheral eosinophilia, commonly reported in association with eosinophilic enteritis. The patient made a rapid clinical response to steroid therapy. The literature on eosinophilic gastroenteritis is reviewed.
 ...
PMID:Eosinophilic gastroenteritis with no peripheral eosinophilia. 402 81

A young patient who suffered from allergic respiratory disease presented with an illness characterized by abdominal pain, diarrhea, and weight loss. Investigations revealed radiological and pathological features consistent with a diagnosis of eosinophilic gastroenteritis. Because of extensive gastric ulceration, treatment with corticosteroids was withheld and in its place oral sodium cromoglycate therapy given. The patient's intestinal symptoms rapidly responded to this treatment and remained controlled for a period of five months. The patient subsequently developed a systemic illness with features of polyarteritis nodosa.
 ...
PMID:Treatment of a patient with clinical features of both eosinophilic gastroenteritis and polyarteritis nodosa with oral sodium cromoglycate. 610 81

Inflammatory fibroid polyp (IFP) is an infrequent condition of the digestive tract which is most often observed in the gastric antrum and ileum. It is known by several synonyms (Vanek tumour, eosinophilic granuloma, etc.) and is sometimes mistaken for eosinophilic gastroenteritis. Its main clinical features are abdominal pain, ulcer-like syndrome, obstruction and/or haemorrhage. It usually runs a benign course and surgery remains the treatment of choice. Its aetiology is unknown. Five cases of gastric IFP are described, one of which was diagnosed from endoscopic biopsies before resection. This is a very uncommon feature which, to our knowledge, has not previously been reported in the literature.
 ...
PMID:[Inflammatory fibroid polyps of the digestive tract. Apropos of 5 cases]. 664 38


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>