Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intravenous leiomyomatosis with a cardiac extension is an extremely rare condition. In this report, a case of a 43-year-old female patient is described: she was operated for right atrial mass protruding into the inferior vena cava, which was later diagnosed as leiomyoma. After a 3-year symptom-free period, recurrence of the extension through the inferior vena cava was observed. After abdominal ultrasonographic examination, which revealed bilateral ovarian and retroperitoneal mass, bilateral oopherectomy, retroperitoneal, and right atrial mass excision was done. The retroperitoneal and right atrial mass was reported as leiomyoma. On her last admission, she had complaints of dizziness, abdominal pain, and bilateral leg edema; and right atrial mass extending through the common iliac vein was noted, but the patient did not accept any further treatment modality.
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PMID:An unusual case of recurrent mass in the right atrium: intravenous leiomyomatosis. 1596 37

Intravenous leiomyomatosis is characterized by a proliferation of benign smooth muscular tissue growing into uterine with malignant appearance. On extremely rare occasions, the tumor may grow out of the pelvis and extend into the inferior vena cava and the right atrium. We report a case of intravenous leiomyomatosis extending into the right atrium. A 41-year-old woman complained of 20 days of intermittent abdominal pain and lower limbs swell. Medical history of the patient revealed a previous hysterectomy operation 3 years ago due to uterine leiomyoma. Echocardiography showed a homogenous mass extending from the inferior vena cava to the right atrium, without evidence of adherence to the right atrial wall, the left ventricular ejection fraction was only 60%. Computer tomography showed that a large mass arising from the left internal iliac vein and extending into the right chambers. Pelvic vascular ultrasound revealed the thrombotic material in the inferior vena cava and the left common iliac vein, and confirmed the presence of a complex mass in the left annex region. Based on the findings, the initial diagnosis was intracardiac and intravenous tumor. An operation was performed through a sternotomy and laparotomy to remove the whole tumor from the left common iliac vein to the right atrium, ligate left internal iliac vein mean-wile. No hormonal therapy was administrated after the operation. Immunohistochemical studies revealed that the tumor cells were fusiform shape, there was no karyokinesis and necrosis, and the tumor cells were positive for smooth muscle antigen and desmin, as well as estrogen receptor and progesterone receptor. Six months postoperation follow-up revealed no signs of recurrence. The differential diagnosis of the disease compared with primary cardiovascular sarcomas and thrombus was difficult. The final diagnosis relied on immunohistochemical analysis, however, the short-term result of operation was acceptable.
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PMID:[Intravenous leiomyomatosis with intracardiac extension: a case report]. 1908 39

Intravenous leiomyomatosis is a rare benign disease. We here in present the case of a 39-year-old woman with a history of hysterectomy who presented with intermittent abdominal pain, palpitations and tightness of the chest. Physical examination revealed the presence of a pelvic mass of regular shape. Gynecological ultrasonography, computed tomography scans and three-dimensional (3D) cardiac ultrasonography were used to evaluate the imaging characteristics of the mass and reach a final diagnosis. The mass appeared to extend to the iliac veins, renal veins and inferior vena cava on imaging examination. The mass was successfully excised under non-extracorporeal circulation in one stage. Pathological examination of tumor samples indicated intravenous leiomyomatosis. After the operation, the symptoms were dissipated and no abnormal echo was observed in the inferior vena cava or the right atrium on 3D-cardiac ultrasonography. The patient is currently followed up without signs of recurrence. The aim of the present study was to describe in detail the diagnostic procedure and treatment in order to improve our current understanding of this disease.
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PMID:Post-hysterectomy intravenous leiomyomatosis: A case of successful multidisciplinary surgery under non-extracorporeal circulation. 2812 26

Intravenous leiomyomatosis is a rare neoplastic condition characterized by the benign intravascular proliferation of smooth muscle cells originating from either the uterine venous wall or a uterine leiomyoma. In the present report, we describe the case of a 36-year-old woman, who was referred to our institution due to abdominal pain. Computed tomography indicated the presence of a giant intravenous leiomyoma originating from the uterus and extending to the right ventricle with complex pathways. The patient was successfully treated by tumor resection under circulatory arrest in two-stage operations in conjunction with gonadotrophin-releasing hormone agonists therapy. She continued to recover and did not exhibit any recurrence at the 8-month follow-up.
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PMID:[Two-stage Surgery for Uterine Intravenous Leiomyomatosis with Right Ventricular Extension;Report of a Case]. 2975 92