Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The prevalence of coeliac disease (CD) was investigated in an epidemiological study of school children from a district of Rome. Mass screening of IgA-AGA levels (anti-gliadin antibody) were determined in blood samples from the study group and the results were positive in 19 children. Eighteen of these agreed to undergo endoscopic biopsy. Histological study of the duodenal specimens revealed villous atrophy in twelve children none of whom had the characteristic symptoms of CD. The most frequent complaints were abdominal pain, aphtous stomatitis, and atopic dermatitis. The high prevalence of CD in this study suggests the necessity for the widest range of epidemiological research.
 ...
PMID:Subclinical coeliac disease. 151 63

Recent studies have been reported for coeliac disease a new prevalence: 1:200 in Europe, 1:184 in Italy. These improvements have been possible for new diagnostic methods and techniques available today: antigliadin, antireticulin and antiendomysium antibodies. These serologic markers have been detected, in recent advances, new clinical presentations for coeliac disease: not only typical gastrointestinal symptoms (diarrhea, recurrent abdominal pain, etc), but many atypical symptoms have been described: sideropenic anemia, short stature, growth retardation, dermatitis herpetiformis, small alterations, alopecia, etc. New groups of patients have been also identified: some patients, clinically asymptomatic, with positive serology and a small intestinal biopsy suggestive for coeliac disease; they have shown histopathologic improvement with gluten free diet ("silent" coeliac disease). Another interesting group consists of asymptomatic patients with a positive serology for AGA and AEA antibodies, but normal gastrointestinal biopsy with free diet; they develop later in life, mucosal atrophy and normalization after gluten free diet ("latent" coeliac disease). It must be emphasized that classes of antibodies (in association with peroneal biopsy) have been identified in the last years, new clinical presentations of coeliac disease and new associations with other autoimmune pathologies.
 ...
PMID:[Celiac disease today]. 926 2