Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirteen cases of amyloidosis are reported from Vanuatu between 1983 and 1985. There appears to be a high incidence of the disease similar to that found in Papua New Guinea. The role of malaria as an aetiological agent is discussed although most cases had a history of past or active tuberculosis. Most patients presented as either nephrotic syndrome or a syndrome of abdominal pain, diarrhoea, weight loss and proteinuria.
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PMID:Amyloidosis in Vanuatu. 361 94

Abdominal tuberculosis, although rare, occurs mainly in immigrants from the Indian subcontinent. Such people comprise 13.5% of our local population and contributed 90% of a series of 72 patients presenting in the last 16 years; a local disease incidence of 1:6000 for Asian immigrants. Men and women were equally affected, but on average women were much younger. Diagnosis was made from one month to 10 years after immigration. No clinical feature was diagnostic, but abdominal pain, night sweats and weight loss occurred in more than half the patients. The erythrocyte sedimentation rate (ESR) was elevated in 95% and no patient tested had a negative Mantoux test. In 20 patients diagnosis was by clinical suspicion and response to therapeutic trial. In 52, including 39 who had a laparotomy, histological and culture material was obtained but these patients fared no better. Only one organism was resistant (to streptomycin) and rapid response to chemotherapy was the rule. Successful outcome was not related to the type of presentation, operative findings or specific chemotherapeutic agents. We would suggest that in Asians presenting with difficult-to-diagnose abdominal symptoms accompanied by malaise, raised ESR and a positive Mantoux test, a therapeutic trial of anti-tuberculous therapy should precede diagnostic laparotomy.
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PMID:Abdominal tuberculosis in East Birmingham--a 16 year study. 365 61

In this retrospective study, clinical presentation of peritoneal tuberculosis in an area with a high prevalence of tuberculosis is discussed. Thirty cases diagnosed in an eight-year period are presented. The disease was 2.3 times more common in females. Eighty per cent of the patients were less than 40 years old. Excluding two cases of long duration (one year and three years), mean duration of the symptoms before admission was 2.3 months. Fever, abdominal pain, swelling and weight loss were the main symptoms. Ascites was clinically detected in 80 per cent of cases. Intermediate strength PPD tuberculin skin test was positive in 61 per cent of cases. In 57.7 per cent there was radiologic evidence of pleuropulmonary disease suggestive of tuberculosis. Fourteen of 15 ascitic fluids examined were exudative in nature with predominance of lymphocytes. In the majority of patients diagnosis was proven with laparotomy and laparoscopy (12 cases in each group). In the remainder, tissue for diagnosis was obtained through blind peritoneal needle biopsy, percutaneous biopsy of liver and peripheral lymph node biopsy (two cases with each method).
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PMID:Tuberculous peritonitis--report of 30 cases and review of the literature. 405 4

In a retrospective survey of 109 patients with gastrointestinal tuberculosis, 91 occurred in immigrants of Asian origin, six were diagnosed at post-mortem, and only 31 had evidence of pulmonary disease. Abdominal pain, weight loss, fever and vomiting were the most common symptoms. Barium contrast studies showed abnormalities in 56 per cent of cases but these could not be distinguished from the changes caused by other chronic inflammatory bowel diseases. Drug treatment was used in all patients, combined with biopsy in 37 and resection in 36. Results of treatment were good with low morbidity and mortality, there were few long-term problems and no relapses have occurred.
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PMID:Gastrointestinal tuberculosis: a retrospective review of 109 cases in a district general hospital. 405 5

The results of diagnostic laparoscopy in 42 patients are reviewed. A histological diagnosis was achieved in 23 of 26 cases of suspected intraperitoneal disease (15 cases of malignant disease, 4 cases of peritoneal or intra-abdominal tuberculosis and 4 cases of benign hepatic lesions in which percutaneous biopsy had failed to obtain a representative specimen). In 10 patients with abdominal trauma the source of the problem was identified, and in 2 of these successful conservative management was undertaken on the basis of the laparoscopic findings. In 6 patients with abdominal pain of unknown cause no lesion could be identified, and the procedure was abandoned in 2 patients because of dense intraperitoneal adhesions. There was no associated mortality and the morbidity rate was 0,5%.
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PMID:Laparoscopy at Baragwanath Hospital, Johannesburg. 623 33

A 58-year-old woman experienced recurrent fever episodes after kidney transplantation. She was treated with antibiotics because of suspicion of staphylococcus infection. Abdominal pain combined with haemorrhagic diarrhoea occurred eight months after transplantation. A barium enema revealed a stenotic process in the middle part of the ascending colon mimicking carcinoma, and hemicolectomy was consequently performed. Histological examination revealed tuberculosis with little granuloma formation and abundant acid-fast tubercle bacilli in the mucosa and submucosa, and only slight perigranulomatous reactions. The patient was successfully treated with triple antituberculous chemotherapy without deterioration of allograft function. Tuberculosis should be suspected in immunosuppressed patients suffering from pyrexia of unknown origin, even when chest X-ray is normal.
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PMID:Tuberculosis of the colon in a kidney transplant patient. 636 69

An autopsy case of erythremia with sideroblastic tumor cell proliferation is described. A 60-year-old man was admitted to the hospital due to general fatigue and anorexia. Bone marrow aspiration revealed abnormalities in erythropoiesis (megaloblasts, 4%; sideroblasts, 84%; ring-formed, 39%, and PAS-positive, 5%). Therapy was directed to pulmonary tuberculosis. Anemia was not improved despite repeated whole blood and platelet transfusions. Serum iron and percentage saturation of the total iron-binding capacity rose during the course. Administration of vitamin B12, B6 or folic acid was inefffective. INAH was replaced by its derivative, IHMS, during the course, but the population of sideroblasts especially of ring-sideroblasts was invariably large (78%-100% and 39%-65% for total sideroblasts and ring-sideroblasts, respectively). He died with increasing abdominal pain and jaundice after three months' hospitalization. Main autopsy findings were: diffuse proliferation of atypical erythroblasts in the bone marrow, systemic lymph nodes, liver, spleen and kidneys. Most of the cells positively stained with iron. Tuberculosis of lungs with cavity formation. Discussion is focussed on the relationship between erythremia and sideroblastic anemia.
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PMID:Erythremia with special reference to sideroblastic anemia. 693 66

A 51-year-old man came to hospital admission one year after the first occurrence of upper abdominal pain, nausea, fever, melaena and discrete symptoms of inflammatory disease, X-ray examination of the chest, colon and ileum were normal. Sonography and computertomographic examination showed a mass in the pancreatic head region. Diagnosis was established by endoscopy and examination of bioptic material, showing ulcerating and stenosing tuberculosis of the duodenum with caseating, tuberculoid granuloma and acid stabile bacilli. Tubercle bacilli of the human type could be demonstrated in bacterial culture. Granuloma of epitheloid cells could also be found in the liver. Drug therapy with tuberculostatic drugs brought about complete healing of the macroscopical lesions within 4 weeks. In patients with stenosing processes of the duodenum tuberculosis should also be taken into account as a rare cause of this condition.
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PMID:[Tuberculous stenosis of the duodenum]. 718 83

The clinical course of 35 patients with tuberculous peritonitis notified in Kandy (Sri Lanka) over a 6-year period has been reviewed. The maximum incidence occurred in the age group 21 to 40 years and the female/male ratio was 3:2. Clinical features were non-specific and the main presenting features were fever (68.5%), abdominal pain (65.7%), abdominal distension (54.2%), abdominal mass (54.2%) and ascites (45.7%). The symptoms were of insidious onset and 85% had symptoms for more than one month. Chest X-ray revealed abnormality suggestive of tuberculosis in 47%. Intra-abdominal tuberculosis was suspected in 43% of 26 patients before laparotomy. Four of the 32 patients given anti-tuberculous drugs died. Overall mortality was 20%.
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PMID:Tuberculous peritonitis: a review of thirty-five cases. 746 73

Mycobacterium genavense is a recently defined fastidious organism that has been identified as a cause of disseminated infection in patients with AIDS. We report the cases of two patients who had advanced AIDS and a clinical syndrome of fever, anorexia, abdominal pain, diarrhea, and weight loss. In addition, splenomegaly and lymphadenopathy were prominent in both cases, and in one patient's case radiographic findings were suggestive of splenic abscesses. Mycobacteria isolated from specimens of blood and bone marrow grew in liquid media but not on solid media. The results of DNA probe tests for Mycobacterium tuberculosis and Mycobacterium avium complex were false-positive for both patients. After treatment of the broth cultures to lyse red blood cells, the results of DNA probe tests were negative for these pathogens. Amplification and sequencing of 16S rRNA with use of the polymerase chain reaction indicated that the mycobacterial isolates from both patients had sequences identical to those previously reported for M. genavense. One patient survived 5 months after diagnosis, the other 2 months after diagnosis; only one patient responded (transiently) to antimycobacterial chemotherapy.
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PMID:Disseminated Mycobacterium genavense infection in two patients with AIDS. 751 19


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