Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Familial mediterranean fever is a childhood disease which usually starts around the age of 4 years. Its onset is insidious with common and misleading symptoms such as fever and abdominal pain. Accordingly, this disease is often recognized belatedly from evocative data from previous history such as the recurrence of attacks, familial descent from certain ethnic groups and the lack of other obvious etiology. The clinical picture within this age group is similar to that observed in adults and does not present any clinical or biological originality. Colchicine remains the only efficient treatment to prevent both acute manifestations and amyloidosis. The former is geared toward its current use among children (growth retardation and gonadic disturbances) and is not really relevant, at least in this particular disease.
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PMID:[Periodic disease of the child]. 134 15

A 48 year-old male patient from Turkey underwent laparotomy 13 years before admission to one unit because of persistent pain in the upper abdomen and fever. Subsequently, he was repeatedly admitted to surgical departments with recurrent upper abdominal pain and fever. The patient was admitted for medical investigation to our department with fever and left pleuritic pain. During this observation period he repeatedly had attacks of fever lasting for one day with leucocytosis. The diagnosis of familial Mediterranean fever was made. Therapy with colchicine (1.5 mg/day) led to complete remission, maintained over the follow-up period of 2 years to date.
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PMID:[Familial Mediterranean fever. Case of a 48-year-old patient with recurrent abdominal pain]. 138 54

A 23-year-old Finnish man was examined because of an 8-year history of recurrent bouts of fever and abdominal pain. His father had been repeatedly investigated because of similar episodes since he was 24 years old, and one of the father's sisters was reported to have had recurrent periods of fever. The clinical features closely resembled those of familial Mediterranean fever (FMF), a syndrome rarely described in families of European descent. Unlike typical FMF, which is inherited as an autosomal recessive trait, the mode of inheritance of the syndrome in our family may be regarded as dominant. During a recent attack, serum concentrations of interleukin-1-beta, interleukin-6 and acute phase reactants, including serum amyloid A protein, were high. No signs of amyloidosis were detected in our patients.
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PMID:Autosomal dominant 'Mediterranean fever' in a Finnish family. 140 41

A 55-year-old male presented with a recurrent fever of over 38 degrees C, occurring at irregular intervals 1-6 times a month with chest, back or abdominal pain. After admission to our hospital, we found the following characteristics: 1) the febrile attacks were accompanied by obvious inflammatory findings and pleuritis or peritonitis; 2) the patient's elder sister had a similar periodic fever; and 3) there were no apparent causative factors responsible for his symptoms. Therefore, we diagnosed this as a case compatible with familial Mediterranean fever. The febrile attacks have been completely suppressed by daily colchicine. This is the seventh case of familial Mediterranean fever reported in Japan.
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PMID:Periodic fever compatible with familial Mediterranean fever. 145 Apr 98

A 24-year-old woman with familial Mediterranean fever (FMF) had for one year been treated with colchicine, 1 mg daily, for repeated bouts of fever, abdominal pain and arthritis. She was also known to have renal amyloidosis. Lately she had developed gastrointestinal symptoms, muscle pain and obvious, predominantly proximal muscular weakness in both legs. The cause of the symptoms was rhabdomyolysis with an increased creatinine activity of 1000 U/l and marked myoglobinuria (1600 micrograms/l), as well as renal failure with normal uric acid and a creatinine clearance of 3 ml/min per 1.73 m2. Serum creatinine concentration was 970 mumol/l, urea 34 mmol/l. Muscle biopsy corresponded to a subacute necrotizing myopathy with vacuole formation, signs typical of toxic damage. Renal biopsy confirmed advanced amyloidosis. The colchicine dose was reduced to 0.5 mg/d. The renal failure responded to conservative treatment. The myopathy symptoms receded within 4 weeks, creatinine clearance rising to 25 ml/min per 1.73 m2. 12 months after reduction of the colchicine dose the patient was without any FMF-related symptoms.
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PMID:[Toxic myopathy with kidney failure as a colchicine side effect ifn familial Mediterranean fever]. 149 22

A 29-year-old patient with familial Mediterranean fever and amyloidosis involving the kidney, liver, and gastrointestinal tract received longterm colchicine, 1 mg daily. In the last year she developed diarrhea and abdominal pain, that coincided with toxic colchicine blood levels. After 2 weeks of oral erythromycin therapy she was hospitalized for acute, life threatening colchicine toxicity, with fever, diarrhea, abdominal pain, myalgia and lower extremity parasthesias and later convulsions and alopecia. Pancytopenia evolved into rebound leukocytosis, disturbed liver function and hypoglycemia. After a long stormy course she improved. Colchicine toxicity with combined liver and renal impairment and the role of erythromycin in her colchicine toxicity are discussed.
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PMID:Acute colchicine intoxication--possible role of erythromycin administration. 157 71

Familial Mediterranean fever (FMF) is an autosomal recessive disorder that occurs most frequently among Sephardic Jews and Armenians. It is characterized by recurrent episodes of fever, peritonitis, pleuritis, and arthritis. Skin lesions are seen in some patients. Diagnosis of FMF usually is made on clinical grounds only, typically when recurrent attacks of abdominal pain, fever, and arthritis are observed in a patient with an appropriate ethnic background and family history. To date, there are no specific diagnostic laboratory tests for FMF. Three patients with severe recurrent Pyoderma are covered in this report. In all three cases, the cutaneous lesions were associated with clinical manifestations of FMF and responded to colchicine therapy favorably. The importance of such an association and its therapeutic consequences are emphasized.
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PMID:Case report: severe pyoderma associated with familial Mediterranean fever--favorable response to colchicine in three patients. 164 50

Six Australian children fulfilled the diagnostic criteria for familial Mediterranean fever. None had a family history of the disease, but five children came from ethnic groups that typically were associated with the disease. The symptoms commenced before five years of age in all the children, and three children underwent unnecessary operations because of the symptoms of recurrent fever and abdominal pain. All six children benefited from colchicine prophylaxis by mouth. More cases can be expected to be recognized in Australia because of the large number of Australian children with a Mediterranean heritage.
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PMID:Familial Mediterranean fever in six Australian children. 279 23

Three patients of Turkish origin with recurrent abdominal complaints and fever are presented. All had consanguineous parents and two were brothers. Biochemistry and haematology were normal except for a high sedimentation rate. With reference to these patients, some aspects of the diagnosis and the therapeutic approach of familial Mediterranean fever are discussed. In patients of Turkish origin who complain of abdominal pain, familial Mediterranean fever should probably be considered more often.
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PMID:[Immigrants with abdominal pain: familial Mediterranean fever?]. 271 88

Familial Mediterranean Fever (FMF), characterized by recurring episodes of fever, serositis, arthritis, skin changes and complicated by amyloidosis in 30%-60% of cases frequently begins in childhood. Systemic juvenile rheumatoid arthritis (systemic JRA, Still's disease) is the most important differential diagnosis. In our series of 10 patients the mean age of onset was 4.9 +/- 2.2 years (range 2-9 years). The mean time period elapsed before the diagnosis was established was 4.1 +/- 2.7 years (range 1.5-10 years). Three of our 10 patients already had developed renal amyloidosis at the time of diagnosis. Essential criteria for differential diagnosis against systemic JRA were positive family history for FMF (4/10), ethnic background (9/10 of Turkish decent), typical erysipeloid skin rashes (4/10), attacks of abdominal pain accompanied by fever (10/10) and the characteristic pattern of recurrent episodes lasting only a few days each (a patient's diary monitoring the attacks may be helpful). In problematic cases the metaraminol provocative test can be helpful. If an elevated plasma dopamine beta-hydroxylase activity appears to be a specific finding in FMF patients, this may well open up new avenues in the early diagnosis of the disease. Since amyloidosis can be prevented by prophylactic long lasting treatment with colchicine, a timely diagnosis of FMF is the physician's challenge.
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PMID:[Familial Mediterranean fever--an important differential diagnosis in systemic juvenile chronic arthritis]. 278 75


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