Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 51-year-old woman with a history of eating raw fish over a period of 2 weeks developed a progressive abdominal pain and leukocytosis with signs of small bowel obstruction. Eosinophilia was not detected in the peripheral blood. The patient underwent surgery to clarify the possibility of ileus. Partial small bowel near the ileum was trapped by a peritoneal strand and was strangulated for approximately 30 cm in length with congestion and edema. The removal of the strand easily released the strangulation and the small bowel returned to a normal appearance. Pathologically, the strand consisted of granulomatous inflammation with a wide zone of necrosis containing a dead ghost feature of a parasite in its center. The necrosis was surrounded by palisading spindle cells with largely lymphocytic infiltration and a few eosinophils. In the parasite, there presented the polymyalian type muscle layer, ventricles and Renette cells, which suggested that the parasite is compatible with the third stage larva of Anisakis type I, leading to the diagnosis of ectopic anisakidosis. It should be noted that, on rare occasions, Anisakis larva migrans can form a peritoneal strand with a wide zone of necrosis and cause strangulation ileus, especially in populations with the habit of eating raw fish.
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PMID:Small bowel strangulation caused by parasitic peritoneal strand. 1670

In June 2006, 118 Singaporean soldiers visited Brunei for jungle training for 10 days. Subsequently, two soldiers had severe diarrhoea and were diagnosed with severe hookworm infection. An epidemiological investigation and case-control study was conducted among the 118 soldiers. A survey was administered to determine the exposures predisposing to infection. Laboratory tests included a full blood count and three separate faecal screens via microscopy and culture. All servicemen were treated with one dose of mebendazole, and follow-up screening was performed 3 months later. Of 113 soldiers completing the questionnaire, 43 soldiers (38%) reported gastrointestinal symptoms post deployment, with 33 (29%) complaining of diarrhoea and 29 (26%) of abdominal pain. Eight had an itch or rash, but none were suggestive of cutaneous larva migrans. Of 103 soldiers completing both the questionnaire and with all the laboratory tests, 42 soldiers (41%) had eosinophilia (>0.6x10(9)/l) and 18 (17%) had hookworm infection on microscopy. More than 89% recalled substantial exposure to soil or groundwater, but no exposure was significantly associated with eosinophilia or infection. After adjusting for possible exposures, not wearing footwear during rest periods had a significantly higher odds ratio (2.86) for acquiring hookworm infection or eosinophilia. Helminth infections are common in visitors to rural Asia. As preventing exposure is often difficult, empirical treatment with anthelminthics should be considered in travellers to high risk areas.
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PMID:Hookworm infections in Singaporean soldiers after jungle training in Brunei Darussalam. 1791 71

We evaluated retrospectively the efficacy and tolerability of oral albendazole (400 mg/day for 1 week) in 78 patients with hookworm-related cutaneous larva migrans characterized by multiple and/or extensive lesions. The diagnosis was based on history and the clinical picture. Neither topical or systemic drugs nor physical treatments were used. All patients were followed-up for at least 3 months after the therapy. All patients were cured at the end of the therapy. The disappearance of pruritus was reported after 2-3 days and skin lesions after 5-7 days of therapy. One patient reported nausea and abdominal pain; another patient reported worsening of pruritus: in both cases it was not necessary to stop the therapy. No recurrences were observed during follow-up. One week of therapy with 400 mg/day oral albendazole is very effective (cure rate: 100%) in patients with cutaneous larva migrans characterized by multiple and/or extensive lesions. This therapeutical regimen is not accompanied by the appearance of new and/or more severe side effects.
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PMID:One-week therapy with oral albendazole in hookworm-related cutaneous larva migrans: a retrospective study on 78 patients. 2129 43

Eosinophilic necrotizing granulomas in the liver, known as visceral larva migrans (VLM), are a rare cause of liver abscesses. The term VLM refers to infections in human tissues caused by the larval stages of ascarid worms of dogs and cats. We report two cases of VLM which presented with high grade fever and abdominal pain for 3-4 months. Marked peripheral eosinophilia, multiple confluent perivenous lesions in the right lobe of liver with characteristic migratory tracts on imaging and biopsy evidence of necrotizing eosinophilic granulomas led to the diagnosis. Complete recovery was achieved with repeated courses of a combination of anthelmintics.
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PMID:Visceral larva migrans presenting as multiple liver abscesses. 2410 Mar 48

A 49-year-old man with chronic hepatitis B receiving treatment with entecavir visited a hospital with a complaint of abdominal pain. Computed tomography (CT) showed 2 liver tumors, each measuring 1cm in diameter, 1 in segment 7 and 1 in segment 4. Magnetic resonance imaging (MRI) showed a hypervascular tumor in segment 7 that appeared in a site different from that seen on CT. The liver tumor in segment 4 was not detected by MRI. Two months later, MRI showed a new liver tumor in segment 7/6 and that the liver tumor in segment 7 had increased to 2cm in diameter;blood tests showed eosinophilia. Enzyme-linked immunosorbent assay showed a high serum Toxocara antibody. The patient was diagnosed as having hepatic toxocariasis and was treated with albendazole for 8 weeks. After treatment, MRI showed that the liver tumors disappeared. Eosinophilia, multiple lesions, and the disappearance of the tumors were characteristic findings of visceral larva migrans.
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PMID:[A case of hepatic toxocariasis in a patient with hepatitis B]. 3216 Dec 49


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