Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixty-eight proved cases of typhoid and paratyphoid fever were reviewed in a retrospective study covering 5 years (1986-1990). Patients within the age range of 10 to 39 years constituted 82.3 per cent of cases and there was equal incidence in both sexes. The mean duration of illness before presentation was 9.67 days. The major clinical features were fever (97%), abdominal tenderness (-9.4%), headache and abdominal pain (70.58%) each). Intestinal perforation was the commonest complication (27.9%) with a male preponderance (M:F-3:1). Perforation occurred after the first week of illness in 73.7 per cent of cases. Fourteen out of the nineteen patients who perforated were not on therapy at the time of perforation and they constituted 80 per cent of those cases of mortality in which perforation played a role. Surgical management of perforation gave better results than conservative management (mortality rates of 16.7% and 40% respectively). Salmonella was sensitive to Chloramphenicol in all the cases where the organism was grown. There were 10 recorded deaths (14.9%) of whom 60 per cent (i. e. 6 patients) presented after two weeks of illness.
 ...
PMID:Typhoid and paratyphoid fever: a retrospective study. 141

Abdominal tuberculosis is a rare disease in Western countries and remains difficult to diagnose. The most frequent symptoms are abdominal pain, weight loss, fever, vomiting, constipation and/or diarrhea. Clinical findings include abdominal tenderness, a palpable mass (often in the right fossa due to ileocecal infection), paleness, cachexia and ascites. Suggested radiological investigations include plain abdominal film, upper GI-series and barium enema. Chest X-rays often show signs of either active or inactive tuberculosis. Sputum and gastric juice should be cultured. Coloscopy serves to sample specimens for histology and bacteriology and may help to confirm the diagnosis, which is, however, not ruled out by negative findings. The same holds good for peritoneal biopsy and laparoscopy. Bowel perforation and ileus are frequent complications and always require surgery, whereas uncomplicated cases can be treated by drugs only.
 ...
PMID:[Abdominal tuberculosis and open lung tuberculosis caused by mycobacterium bovis]. 265 75

Most of the laparoscopy procedures performed in the U. S. use electric current to coagulate the fallopian tubes. Most of the coagulations are done with unipolar devices, with its attendant risks of accidental burns to the patient and the operator. In the years 1978 and 1979, 2 sterilization-related deaths were recorded by the Center for Disease Control, apparently resulting form inadvertent burns to the bowel sustained during sterilization with unipolar devices. The 1st case involved a 41-year old woman, gravida 6, para 5, abortus 1 who underwent a laparoscopic tubal sterilization via electrocoagulation with a unipolar device. 23 days after the operation, she returned to the hospital complaining of abdominal pain and evidence of peritonitis. Laparotomy was performed, but her condition deteriorated. She died 41 days after the laparotomy. Autopsy revealed bowel perforation with subcutaneous abscess. The 2nd case involved a healthy 22-year old woman, gravida 4, para 4 who underwent a similar sterilization procedure. She presented to the hospital 7 days after the operation complaining of abdominal pain. Laparotomy was also performed but she died two days later of septic shock. Bowel perforation was strongly suspected, although the perforation site was never located. Bipolar coagulation may reduce the risk of electric accidents. The need for continuing the use of unipolar electrocoagulation, in the light of risk of death, is questioned.
 ...
PMID:Deaths associated with laparoscopic sterilization by unipolar electrocoagulating devices, 1978 and 1979. 645 May 36

Bowel perforation in patients with primary malignant lymphoma usually occurs at the site of tumor. A 78 year-old man underwent chemotherapy for malignant lymphoma. He presented with abdominal pain. An emergency operation was performed under a diagnosis of panperitonitis. At laparotomy, an anal-side perforation approximately 20 cm from the Treiz ligament was observed. Drainage and partial resection of the jejunum was performed. Histopathologic examination demonstrated that there was no characteristic finding of malignant lymphoma around the perforation site in the case. Perforation of the small intestine is one of the most critical complications during the chemotherapy for malignant lymphoma. In cases of chemotherapy for malignant lymphoma, especially systemic administration, we should keep in mind the possibility of perforation of the small intestine. Fortunately, emergency surgery saved the patient presented in this report. Early diagnosis and treatment are important to improve prognosis of bowel perforation in patients with primary malignant lymphoma.
 ...
PMID:Bowel perforation during chemotherapy for non-hodgkin's lymphoma. 1062 81

This is a case report of intestinal eosinophilic granuloma caused by Ascaris ova and worm which is supposed to be rare in Korea. CASE: A 23 year old healthy female reached Pusan Sanitation Hospital with complaints of high fever and abdominal pain on December 3 in 1966. Examination: Her temperature was 99.6'F. Pulse 80. Abdominal palpation showed muscle rigidity and tenderness. On the right side of the abdomen diagnosis due to ruptured appendix was made, and a laparotomy was performed the same day. OPERATION: Intestinal perforation by a Ascaris worm in the caecum about 7 cm from the ileo-caecal junction was also found. The worm was liquefied already. The intestine was edematous. Numerous rice sized nodules were seen on the intestine. The omentum was markdly inflammed and was adhered with a fist size mass. The mass and appendix were also resected in order to do a histological study. PATHOLOGY: Two kinds of tissues were examined : one a mesenteric mass, the other lymph node. MICROSCOPICALLY: it showed intensive and entirely necrotic tissue in which numerous parasitic ova were surrounded by granulomatous inflammatory cells with eosinophiles. The parasitic ova were degenerative and partialy necrotic although they had three layers of egg shell which are identified with Ascaris ova.
 ...
PMID:[A case report of intestinal eosinophilic granuloma du to Ascaris Ova] 1291 98

Yersinia enterocolitica infection is responsible in human beings for ileocolitis appearing with abdominal pain, diarrhoea and fever. This kind of disease usually heals spontaneously with no remarkable complication. Intestinal perforation is a rare complication of the disease. To date only eleven cases of surgical complications arising from abscess and intestinal perforation due to Yersinia enterocolitica have been reported in literature. In our clinical case the patient, who had previously undergone appendicectomy, required urgent surgery for pelvi-peritonitis due to intestinal perforation on necrotic-ulcerative ileitis with adenomesenteritis from Yersinia enterocolitica. The surgical treatment combined with intestinal resection and targeted antibiotic therapy have proved to be effective.
 ...
PMID:Yersinia enterocolitica intestinal infection with ileum perforation: report of a clinical observation. 1531 92

A 46-year-old non-obese woman with no previous history of pelvic surgery underwent a tension-free vaginal tape (TVT) procedure for the treatment of stress urinary incontinence. Perioperative cystoscopy revealed that both trocars had perforated the bladder. The procedure was cancelled due to excessive bleeding in the bladder, which impaired visibility by cystoscopy. Postoperatively the patient had increasing abdominal pain, anaemia and a tendency to collapse. Laparotomy was performed and, in addition to a haematoma in the retropubic space, 2 perforations were detected in the small intestine; these perforations were closed. Bowel perforations during TVT procedures are rare but sometimes fatal. They have been described in the literature and appear to be under-reported. Patients typically develop symptoms immediately after surgery, but some exceptional cases may develop symptoms after a few months. Bowel perforation should be considered when unexplainable symptoms arise after a minimally invasive procedure like TVT. Because this rare complication can be life-threatening, early recognition is very important.
 ...
PMID:[Bowel perforation during placement of a tension-free vaginal tape for stress urinary incontinence]. 1854 29

Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF), and it has shown promise as a clinical agent against metastatic colorectal cancer, and particularly in combination with chemotherapy. Bowel perforation is a known risk that's associated with bevacizumab use, but the etiology is unknown. Here we report on two cases of metastatic colorectal cancer in which the patients suffered from intestinal perforation after chemotherapy with bevacizumab. For the first case, a 47 year-old man had rectal cancer with concurrent liver and lung metastasis. He underwent chemotherapy with 5-fluorouracil, irinotecan and bevacizumab. Fever and abdominal pain developed seven days later, and rectal perforation was identified upon exploration 13 days later. For the second case, a 48 year-old woman had sigmoid colon cancer with peritoneal and ovary metastases. After seven days of chemotherapy with 5-fluorouracil, oxaliplatin and bevacizumab, exploratory surgery revealed a perforation at the ileum.
 ...
PMID:Intestinal perforation in colorectal cancers treated with bevacizumab (Avastin). 1968 63

A 56-year-old woman was maintained on continuous ambulatory peritoneal dialysis (PD) for 12 years. The patient presented to our hospital with chief complaints of intermittent abdominal pain and frequent loose stool. Plain radiograph of abdomen revealed extensive peritoneal calcification. Computed tomography confirmed the extensive peritoneal calcification and revealed a large right ovarian cyst. Torsion of the right ovarian cyst was suspected. Right oophorectomy was performed. Small intestinal perforation developed 37 days after the operation. The patient expired because of peritonitis and sepsis. Extensive peritoneal calcification is a rare and serious complication after long-term PD. Intestinal perforation is a rare complication of PD. Pathognomic signs of imaging studies can be important in early diagnosis and treatment.
 ...
PMID:Extensive peritoneal calcification and small intestinal perforation in a peritoneal dialysis patient: a case report. 2152 88

(Case 1) An 82-year-old man started immunotherapy with interferon because of lung metastasis 5 years after he had undergone radical nephrectomy. Three years later, he developed multiple metastases, and was started on sorafenib (400 mg/day) and nonsteroidal anti-inflammatory drug (NSAID) orally. As his cancer-related pain worsened with time, he was administered 30 Gy radiation therapy for bone metastasis of L4. He was then admitted to our hospital for pain control because of ineffective radiation therapy. One day, he suddenly had abdominal pain and vomiting, and was diagnosed as bowel perforation based on computed tomography. He was managed conservatively by nasogastric suction and antibiotic course. (Case 2) A 62-year-old man diagnosed as metastatic renal cell cancer began immunotherapy soon after undergoing radical nephrectomy in Dec., 2006. Although he was started on oral sorafenib (800 mg/day) in July, 2008, metastatic foci enlarged after 18 months. He was then changed to sunitinib (50 mg/day). Sunitinib had immediate and long-lasting effect on the cancer for about 10 months, but he was then admitted to our hospital for pleural effusion. While under treatment for thoracic cavity drainage, he experienced upper abdominal pain and was diagnosis as bowel perforation based on computed tomography. He underwent emergency laparotomy. Molecular target drugs such as sorafenib and sunitinib have serious adverse effects. Bowel perforation is rare, but among those adverse effects. It should be remembered that caution is required for long-term use or combined radiation therapy and NSAIDs with molecular target drug.
 ...
PMID:[Two cases of bowel perforation in patients with metastatic renal cancer treated with a molecularly targeted drug]. 2334 25


1 2 3 Next >>