Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 415 women treated for laparoscopically verified pelvic inflammatory disease (PID) were reviewed after 9.5 years. Of these, 88 (21.2 per cent) were involuntarily childless after one or more infection; in 72 cases (17.3 per cent) this was due to tubal obstruction; 263 (63.4 per cent) women became pregnant; 64 (15.4 per cent) were voluntarily childless. Tubal occlusion was diagnosed after one infection in 12.8 per cent, after two infections in 35.5 per cent, and after three or more infections in 75 per cent of the women. Tubal occlusion was more common after nongonorrheal than after gonorrheal salpingitis. Infertility varied with the inflammatory changes seen at laparoscopy. The ratio between ectopic and intrauterine pregnancies after the infections was 1/24. Chronic abdominal pain was reported by 18.1 per cent of the women. Corresponding findings in 100 healthy control subjects were: involuntary childlessness in three despite normal Fallopian tubes, one ectopic in 147 intrauterine pregnancies, and chronic abdominal pain in five cases.
 ...
PMID:Effect of acute pelvic inflammatory disease on fertility. 12 23

In Holland, infertility specialists at Sophia Hospital in Zwolle administered human menotropins chorionic gonadotropin injections to a 26-year old woman to induce ovulation. Donor artificial insemination resulted in conception. At 8 weeks gestation, ultrasonography revealed 5 fetuses. Since quintuplet pregnancies increase the risk of maternal complications and of perinatal morbidity and mortality, she consented to embryo reduction at 11 weeks gestation, resulting in a twin pregnancy. Between 16-18 weeks gestation, she had some vaginal bleeding. At 22.5 weeks gestation, she suffered lower abdominal pain and fluid loss and delivered a 310 fm female who died within a few hours. The physicians ligated the umbilical cord with vicryl near the cervix. The gestational sac of twin B was sticking out of the internal ostium, but she did not deliver twin B. There were no signs of placental separation or of infection. The woman and her husband agreed to postpone delivery of the 2nd fetus. She remained in bed while receiving iv tocolytic drugs (ritodrine R). The physicians also administered iv antibiotics for 3 days (ampicilline and cefotaxim). Weekly ultrasound examination showed that twin B grew normally. A subfebrile temperature and an increase in the white blood cell count resulted in restart of antibiotic therapy. Health workers gave her intramuscular injections of betamethasone to accelerate development of the fetus' lungs at 26 weeks. 2 days later, she went into labor. The physicians ruptured the membranes and delivered a 710 gm male newborn. She later delivered 3 intact amniotic sacs with autolytic fetuses. She recovered uneventfully. The newborn eventually developed bronchopulmonary dysplasia and dies at 3 months. None of the 1st-born infant in 14 delayed interval delivery cases reported in the literature since 1957 survived. 13 of the 17 later born infants did survive. Tocolytic agents were used to postpone delivery in 10 cases. Cervical cerclage was done in the 7 other cases. All but 1 case received broad-spectrum antibiotics.
 ...
PMID:Delayed interval delivery of two remaining fetuses in quintuplet pregnancy after embryo reduction: report and review of the literature. 148 56

During the past decade, the development of various gonadotrophin-releasing hormone (Gn-RH) agonists, which induce reversible hypo-oestrogenism has opened a new area in the medical management of endometriosis. In an open, multicentre phase III study, the efficacy, tolerance and safety of the Gn-RH agonist leuprorelin acetate were tested. The preliminary results of 104 women treated in seven German centres are presented. Pelvic endometriosis was diagnosed by laparoscopy and classified according to the American Fertility Society scoring system: 33% of patients had minimal, 22% mild, 28% moderate and 8% severe endometriosis and in 9% no pathological results were obtained. The patients' mean age was 30 +/- 6 years and 66 had infertility problems. Treatment was started within the first 3 days of the menstrual cycle and consisted of a subcutaneous injection of leuprorelin acetate 3.75 mg, repeated once monthly over 24 weeks. A follow-up period of 12 months after the last injection has been completed in 70 patients, including a second laparoscopy. At all visits, symptoms were evaluated, physical examinations performed, and blood samples collected for haematological screening, serum chemistry determinations and measurement of the gonadotrophins oestradiol and progesterone and leuprorelin acetate. The median score at laparoscopy fell from 12 before operation to 8 after operation and 2 after treatment with leuprorelin acetate. Of the total number of patients, 89% had improvements in their endometriosis, 8% a deterioration and 3% no change. Patients reported improvement in the following: dysmenorrhoea 93%, dyspareunia 62% and pelvic pain 70%. However, all women complained of at least one of the following symptoms: hot flushes 86%, sleep disturbance 62%, sweating 61%, headache 41%, nausea 32% and depression 20%. Fifty-five percent of patients reported additional side effects such as vaginal dryness, fatigue and lower abdominal pain. After the third injection, amenorrhoea persisted in 94% of the women. Four weeks after the first leuprorelin acetate injection median concentrations of oestradiol fell from 45 pg/ml to 11 pg/ml, follicle-stimulating hormone from 7 U/L to 3 U/L and luteinising hormone from 5 U/L to 1 U/L and remained almost unchanged over the observation period. During the 6 months' treatment, laboratory parameters showed no significant deviations from normal; only total cholesterol, high-density lipoprotein cholesterol and alkaline phosphatase increased. Treatment results were judged as good and satisfactory in 82% and 11% of cases, respectively. On the basis of this study, it can be concluded that leuprorelin acetate treatment is safe, well tolerated and effective in the medical management of endometriosis and endometriosis-related complaints.
 ...
PMID:Treatment of endometriosis with leuprorelin acetate depot: a German multicentre study. 153 21

True unicornuate uterus is a rare anomaly which is often associated with renal tract anomalies, and may predispose to infertility and pregnancy complications. Three additional cases are reported here. One of the women had associated bony and cardiac anomalies, although there was no good evidence that these were part of a syndrome. The diagnosis in each case was made incidentally during the surgical investigation of abdominal pain, which in one case was caused by an ectopic pregnancy, itself a rare occurrence with unicornuate uterus.
 ...
PMID:Unicornuate uterus. 167 50

Acute renal failure (ARF) complicated the use of traditional herbal remedies in six adult patients seen at Kenyatta National Hospital in a 2-year period (August 1984 to August 1986). This comprised 10.9% of all the cases of ARF and 24% of the cases of ARF due to medical causes. All the patients were oliguric and the period of oliguria in the four patients who survived ranged between 19-57 days (mean 26.3 days). Five of the patients had evidence of fluid overload. The blood urea nitrogen and serum creatinine were elevated in all the patients. The serum sodium was normal in all, while the serum potassium was elevated in 2 cases. Identity of the herbal medication was unknown in all the cases. The indication was abdominal pain in 4 cases, infertility and abdominal pain in one and prophylaxis against witchcraft in the other. All the patients were started on haemodialysis, two of them having had periods of peritoneal dialysis for 12 and 16 days. Two patients died. Of the four surviving patients, follow up has been carried out for 8, 6, 5 and 4 months. At four months follow up the creatinine clearance in the 4 surviving patients have been 54, 63, 51 and 43 ml/min.
 ...
PMID:Acute renal failure following the use of herbal remedies. 180 Jan

A group of 1542 premenopausal Caucasian women were assessed prospectively to investigate the prevalence of endometriosis. The women either underwent laparoscopy because of infertility (n=654), because of laparoscopic sterilization (n=598), because of chronic abdominal and pelvic pain (n=156), or underwent abdominal hysterectomy for dysfunctional uterine bleeding (n=134). Endometriosis was seen more frequently among women being investigated for infertility (21%) than among those undergoing sterilization (6%). For those experiencing chronic abdominal pain, the incidence of endometriosis was 15%, while among those undergoing abdominal hysterectomy it was 25%. In all groups, the total duration of combined pill usage was significantly higher in those who had normal pelvis compared with those with endometriosis. It is suggested that among susceptible women, both fertile and infertile, a prolonged period of regular spontaneous menstruation may play a causative role in the etiology of endometriosis.
 ...
PMID:Prevalence and genesis of endometriosis. 191 5

To evaluate the efficacy, safety and tolerance of the GnRH-analogue Buserelin in the treatment of endometriosis, we started a non-comparative study of 52 patients with various stages of endometriosis. The dosage of 900 mcg/d was administered 3 times daily intranasally for 6 months. The degree of the disease was evaluated before and at the end of treatment by pelviscopy and biopsy. A regression of the implant score was found in 88% of patients. The mean AFS score was reduced from 17.4 +/- 1.9 before medication to 7.2 +/- 8.2 after therapy. Endometriosis related complaints were significantly improved during treatment. After 6 months 75% of the patients were without lower abdominal pain, 98% without dysmenorrhoea, and 85% without dyspareunia. As a result of the induced low level of oestrogen, 60% of the patients claimed hot flushes, 12% sweating, reduced libido, and dry vagina. Bleeding (spotting, break-through bleeding, menstruation) occurred in 40% during the first month, and was continuously reduced during the following period. Before, during and after therapy, venous blood samples were drawn to check laboratory tests for blood count, clotting parameters, clinical chemistry, serum electrolytes, as well as liver and lipid metabolism. All values stayed within the normal range without significant changes. In the follow-up period of at least 12 months, we achieved an uncorrected pregnancy rate of 41% in the group of 34 women with primary or secondary infertility.
 ...
PMID:[Ovarian suppression by the GnRH analog buserelin in the treatment of endometriosis. Clinical, biochemical and pelviscopic studies]. 214 92

A 9-year-old American Saddlebred mare was referred because of abdominal distention and signs of abdominal pain. Copious peritoneal fluid obtained by abdominocentesis appeared to be frank blood. Rectal and ultrasonographic evaluation of the abdomen revealed a large mass at the distal tip of the right uterine horn. The mare was euthanatized and necropsied and the mass was determined to be a granulosa-thecal cell neoplasm. The most common clinical sign of granulosa-thecal cell neoplasm is infertility or abnormal sexual behavior. Hemoperitoneum is infrequently associated with neoplasms in horses.
 ...
PMID:Intra-abdominal hemorrhage associated with a granulosa-thecal cell neoplasm in a mare. 216 11

Risk factors for ectopic pregnancy include previous ectopic pregnancy, current intrauterine device use, prior fallopian tube surgery, previous pelvic inflammatory disease and a prior history of infertility. Abdominal pain is the most common symptom, followed by amenorrhea or vaginal bleeding, nausea, vomiting, syncope and dizziness. Referred shoulder pain following the onset of abdominal pain is characteristic of intraperitoneal bleeding and, in the appropriate clinical setting, strongly suggests a ruptured ectopic pregnancy. A coordinated evaluation includes measurement of serum human chorionic gonadotropin concentration and transabdominal or, preferably, transvaginal ultrasonography. Treatment is primarily by one of a variety of surgical techniques. Medical therapy with methotrexate or other drugs is currently under investigation.
 ...
PMID:Management of ectopic pregnancy. 218 38

Recent literature concerning genital tuberculosis in women is reviewed. In Denmark, 25% of the cases are observed in immigrants. The symptoms are non-specific in the form of infertility, metrorrhagia or abdominal pain. Positive culture or specific histology are necessary to establish the diagnosis. Approximately one third of the cases are recognized first during or after operation in connection with laparotomy on suspicion of another condition. Treatment is primarily combined therapy with rifampicin, isoniazide and ethambutol for nine months. If treatment fails or pain persists, total hysterectomy and bilateral salpingectomy are indicated. Bilateral oophorectomy in younger patients with normal ovaries has been discussed. The prognosis as regards survival is good but the patients must be considered to be infertile.
 ...
PMID:[Genital tuberculosis in women]. 219 49


1 2 3 4 5 6 7 8 9 10 Next >>