Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To determine whether serum antibody to Chlamydia trachomatis antigens alters the risk of C. trachomatis pelvic inflammatory disease (PID), 280 female sex workers were prospectively evaluated over a 33-month period for incident C. trachomatis and Neisseria gonorrhoeae cervical infection and for clinical PID. At enrollment, women were tested for antibody to C. trachomatis elementary bodies by an indirect microimmunofluorescence assay and to recombinant chlamydial hsp60 (Chsp60) by an ELISA format. At each follow-up visit, women were tested for cervical chlamydial and gonococcal infection and were identified as having clinical PID if they complained of lower abdominal pain and were found to have uterine and adnexal tenderness on pelvic examination. The data demonstrate that antibody to Chsp60 predicts a 2- to 3-fold increased risk for C. trachomatis PID.
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PMID:Antibody to chlamydial hsp60 predicts an increased risk for chlamydial pelvic inflammatory disease. 912 79

The symptom of lower abdominal pain in women is extremely common and does not always indicate the presence of serious illness. However, women with certain serious conditions such as pelvic inflammatory disease (PID), acute appendicitis, ectopic pregnancy and other complications of pregnancy may present initially with this symptom. Therefore, in managing women with lower abdominal pain care should be taken to exclude any serious condition before dismissing the patient. PID is a condition in which there is infection of the reproductive tract of women above the internal os of the cervix. This usually occurs as a result of an ascending cervical infection caused by Neisseria gonorrhoeae, Chlamydia trachomatis and anaerobic bacteria. The immediate and long term effects of PID include salpingitis, pelvic abscess, peritonitis, infertility and predisposition to tubal ectopic pregnancy. Women with lower abdominal pain should be assessed carefully and if PID is the cause they should be treated for gonococcal, chlamydial and anaerobic bacterial infection. Other gynaecological and surgical causes of lower abdominal pain and the immediate complications of PID require urgent referral to a specialist. PID is associated with significant morbidity and mortality.
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PMID:Syndromic management of sexually transmitted diseases. Part 4--The management of lower abdominal pain in women. 1018 53

Adolescents remain a group at particular risk for STD acquisition due to a combination of biological and psychosocial factors. Access to care can be an obstacle to seeking appropriate screening and treatment for many adolescents; undetected infection may lead to unwanted sequelae, including pelvic inflammatory disease, chronic abdominal pain, tubal scarring, and increased risk of ectopic pregnancy. With respect to gonorrhea, chlamydia, syphilis, and chancroid, the hope is that improved detection will decrease sequelae by prompting earlier recognition and treatment. In all cases of suspected sexual abuse cultures remain of utmost importance because of the negative consequences associated with a possible false-positive test result. Urine screening in certain settings, such as school-based health centers and juvenile detention centers, remains positive; however, adolescents with a positive test may still require further evaluation to identify HPV and abnormal Pap smear findings, syphilis, and other STDs currently not recognizable with a simple urine screen.
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PMID:Sexually transmitted diseases: testing and treating. 1037 Jul 7

Management of sexually transmitted diseases (STDs) requires not only diagnosis and treatment but also setting up a health education program and conducting follow-up. The health provider needs tactfully and respectfully to ask each patient about the symptoms responsible for his/her seeking health care. In taking this case history, the provider should use words understandable by the patient. As soon as possible and after having explained what is going to happen and obtaining informed consent, the provider must perform a physical examination of the genitals, the anal region, and the groin to look for STD signs (e.g., habitual genital discharge). After having determined the current STD symptoms, the provider needs to follow the appropriate algorithms (decision making tools) in order to prescribe treatment while emphasizing the need for the patient to correctly follow treatment. Next, the provider needs clearly to explain how STDs are transmitted, the importance of treatment of the partner, and ways to prevent STDs (e.g., condom use). The provider needs to ask the patient to return in seven days for a follow-up consultation. During the follow-up visit, the provider needs to ask about change in symptoms, sexual activity, and condom use or nonuse and to perform a physical examination. The article provides specific algorithms and treatment options for the major STD signs and symptoms: genital ulcers, penal discharge, abdominal pain, vaginal discharge (i.e., leucorrhea). For example, if a man has genital discharge, gonorrhea or chlamydia may be responsible. The type of discharge helps identify the etiologic agent: gonorrhea tends to produce a yellow discharge that resembles pus while chlamydia produces a less thick discharge. Recommended antibiotics for gonorrhea are cefixime, ceftriaxone, ciprofloxacine (contraindicated for pregnant women), spectinomycin, kanamycin, and trimethroprim/sulfamethoxazole. Recommended drugs for chlamydia are doxycycline, tetracycline, and erythromycin.
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PMID:[Management of STDS at the primary care level. Recommendations for STD treatment]. 1229 20

Each year 250 million new cases of sexually transmitted diseases (STDs) have the potential to cause pelvic inflammatory disease, infertility, blindness, and death. Sometimes the onset of these STDs is symptomless, but the following conditions indicate the presence of an STD: genital discharge, sores, wounds, or blisters; swollen glands in the groin; cauliflower-like growths on the genitals; skin rash; lower abdominal pain in females; painful swelling in the testicles; alopecia; discharge from the eyes; and pain during intercourse. The 5 most common STDs which can be cured with antibiotics are chancroid, chlamydial infection, gonorrhea, syphilis, and trichomoniasis. By the end of 1994 in Uganda, 390 primary health units will be available for STD treatment, and most health workers will be trained in STD patient management. Since patients will receive the minimum amount of treatment needed to cure the STD, they will be well advised to use the drugs provided. Notification of all recent sex partners is also essential, and sex partners should be evaluated even if they are asymptomatic. Patients are advised to engage in safe sex behavior, including remaining faithful to a monogamous relationship and using condoms, and to seek medical advice if they develop STD symptoms or are exposed to STD. The AIDS virus is also transmitted through sexual intercourse as well as through blood transfusions, from mother to child, and through the use of contaminated needles. HIV infection progresses from a stage where it cannot be detected to an asymptomatic stage to a symptomatic stage. Chronic diarrhea, fever, and weight loss are the major symptoms. There is no treatment for HIV infection, but zidovudine (AZT) can delay progress of the disease. The most important treatment available is counseling and understanding. The Uganda AIDS Commission works to control the disease through education, treatment of STDs, provision of safe blood for transfusion, monitoring, counseling patients, and promoting research. The primary objective in the care of AIDS patients is to improve the quality of their life as much as possible.
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PMID:Telling signs and symptoms. 1231 60

800 cases of pelvic inflammation (PI) admitted to the Civic Hospital, Ahmedabad, between October 1967 and August 1974 were studied. 772 (96.5) of these cases involved chronic PI (420 of doubtful etiology, 122 postpartum, 76 postabortal, 46 tuberculous, 33 gonococcal, and 75 postinstrumental). A further 28 cases (3.5%) represented acute PI (19 of doubtful etiology, 5 postinstrumental, and 4 postabortal). 87% of cases were 20-35 years of age. The most frequent clinical symptom was some form of menstrual disturbance (polymenorrhea, 14.87%; dysmenorrhea, 13.5%; scanty period, 11.13%; menorrhagia, 13.37%; and irregular, profuse period, 14%). 48% of the women complained of acute or chronic lower abdominal pain, and 31.1% experienced leukorrhea or purulent vaginal discharge. Sterility was found in 25% of cases. 50% of women with acute PI, 37.6% of those with chronic PI, and 6.52% of those with tubercular PI reported regular menstrual cycles. The most common organism isolated was Escherichia coli (38.45% of cases). Other organisms detected included staphylococcus (10.75%) and gonococci (8.61%). No organism was isolated in 33.78% of cases. The response to treatment with various antibiotics and cortisone was considered good in 28% of cases, fair in 37%, and poor or no response in 36%. Patients given a combined therapy of chloromycetin and corticosteroids showed early recovery and complete resolution of inflammatory masses. Follow-up study revealed that menstrual disorders were cured in 57% of cases and abdominal pain was relieved in 53%.
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PMID:Pelvic inflammation (a study of 800 cases). 1232 59

Patients with sexually transmitted diseases (STDs) in developing countries are often untreated for long periods of time or receive ineffective treatment, producing complications that can lead to infertility, blindness, and even death. In addition, there is growing research evidence that people with bacterial or viral STDs are more likely to acquire--and perhaps transmit--the human immunodeficiency virus (HIV). STD control programs in developing countries must be reorganized to include: 1) good management of patients with STDs and their contacts, 2) case finding for syphilis in the antenatal population, 3) screenings and case findings for gonorrhea in high-risk groups, and 4) systematic prophylaxis for ophthalmia neonatorum in newborns. Since diagnosis before treatment is problematic in rural areas, the World Health Organization recommends simple treatment protocols based on the most common STD symptoms--urethral discharge; gynecological complaints such as vaginal discharge, low abdominal pain, or dysuria; genital ulceration; and inguinal bubo, a swelling of the lymph nodes in the groin. Other components of this approach include standardized treatment, contact tracing and treatment, health education targeted at high-risk groups, follow-up and case referral where necessary, and the collection of simple statistics on treatment efficacy and STD epidemiology. The incidence of STDs in developing countries is steadily increasing as a result of urbanization, increased numbers of young people, and delayed age at marriage. However, this situation can be combatted through application of treatment protocols, technological advances, improvements in the health care delivery system, and awareness on the part of policy makers of the seriousness of the STD problem.
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PMID:Management of sexually transmitted diseases. 1234 18

Some 250 million cases of sexually transmitted disease (STD) occur each year, and in some countries 1 or even 2 women in every 10 are infected with an STD. STDs are likely to reach an advanced stage before women notice them. The consequences of STDs are devastating, according to a report by the Population Information Program of the Johns Hopkins School of Public Health, and they include stillbirths, blinding eye infections in the newborn, chronic female abdominal pain, ectopic pregnancy, and infertility. There are social consequences for women such as divorce, and husbands may abandon infertile wives. Gonorrhea and chlamydia can cause both severe inflammation of the pelvis with acute pain and possible infertility. Pelvic inflammatory disease can permanently scar the fallopian tubes, increasing the risk of ectopic pregnancy, which can be fatal when the fallopian tube ruptures. Babies born to mothers with gonorrhea and chlamydia are likely to develop eye infections that may make them blind. Chlamydia infection in pregnant women may also cause premature rupture of the membranes, sepsis, and the death of premature neonate. Infection may spread to the lungs of newborns, leading to chlamydial pneumonia. Syphilis can cause spontaneous abortion, stillbirth, neonatal death, or congenital syphilis in the infant. Trichomoniasis and herpes can also be transmitted from mother to fetus. And infection with an STD increases the risk of infection with the human immunodeficiency virus (HIV). The World Health Organization (WHO) recommends that prenatal care should always include checks for STDs. A WHO Technical Working Group on Care of Mother and Baby has stressed the importance of detecting and treating STDs in pregnant women. The working group urged training of health workers to distinguish between STDs and other infections. The group, which met July 5-9, 1993, outlined health center strategies for prevention and treatment.
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PMID:STDs infect 250 million a year. 1234

According to World Health Organization estimates, there are 333 million new cases of sexually transmitted diseases (STDs) each year. The total number of reproductive tract infections (RTIs) is even higher since these infections may have few visible symptoms, especially in women. Left untreated, however, RTIs can lead to infertility. Common symptoms include: unusually thick or foul-smelling vaginal or urethral discharge, genital sores, anal sores, genital itching, pain when urinating and during sexual intercourse, painful swelling in the lymph glands or groin, and lower abdominal pain. The open sores associated with STDs such as syphilis, chancroid, and genital herpes greatly increase the risk of HIV transmission, as may STDs such as gonorrhea that are associated with urethral or vaginal discharge. To facilitate the prompt diagnosis and treatment of RTIs, this article briefly describes the diagnosis and long-term effects of gonorrhea, syphilis, chancroid, chlamydia, pelvic inflammatory disease, genital herpes, genital warts, candida, and bacterial vaginosis.
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PMID:Common infections. 1234 38

Sexually transmitted diseases (STD) are quite common and observed more frequently in teens. The adolescents represent a group at particular risk for STD due to biological, sociocultural and psychological factors. Undectected infections may lead to unwanted sequelae, including pelvic inflammatory disease, chronic abdominal pain, tubal scarring and increased risk of ectopic pregnancy. This paper deals with infections by Candida albicans, Chlamidia tracomatis, Neisseria gonorrheae, Gardnerella vaginalis, Treponema pallidum, Tricomonas vaginalis, Herpes simplex, Papilloma virus. In regard to gonorrhea, chlamydia, syphilis and papilloma virus, the expectation is that improved detection will decrease sequelae by early diagnosis and treatment. Prevention programs (information, use of hormonal contraception associated with condom use) and improved access to STD diagnosis and treatment services are useful to reduce the incidence of STD among young people.
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PMID:[Sexually transmitted infections]. 1238 42


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