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Query: UMLS:C0000737 (abdominal pain)
 31,184 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The value of transvaginal colour and pulse wave Doppler in the diagnosis of pathologic early intrauterine and tubal pregnancy was assessed. Forty-one normal pregnancies, 6 blighted ovum, 6 missed abortions, and 22 suspected ectopic pregnancies (13 proven tubal pregnancies) were examined. Single 5 MHz transvaginal colour and pulse wave Doppler probe was used and once clear signals from uterine vessels, umbilical artery or trophoblastic vessels were obtained. Resistance Index (peak systole--end diastole/peak systole, RI) from the corresponding waveforms was calculated. In 41 normal pregnancies (examined before termination of pregnancy) with gestational age ranged from 6 to 10 weeks mean RI in uterine artery was 0.81 (SD 0.06), in the umbilical artery 1 (SD 0), and 0.48 (0.08) in the trophoblastic vessels. Mean RI from uterine arteries in six pregnancies with blighted ovum and six with missed abortion were 0.77 (SD 0.11) and 0.69 (SD 0.13) respectively. In 2 out of 6 cases of blighted ovum and 4 out of 6 cases of missed abortion flow in trophoblastic vessels could not be detected. These findings suggest ineffective early placentation in pathologic pregnancy. Twenty-two patients with suspected ectopic pregnancy (raised serum beta HCG with empty uterus, amenorrhoea with abdominal pain and/or palpable abdominal mass) were examined. In 13 cases tubal pregnancy was confirmed by laparoscopy and/or laparotomy. In the remaining nine cases the diagnosis was excluded by means of laparoscopy or subsequent negative beta HCG. Doppler diagnosis of ectopic pregnancy was made when colour flow in adnexa with RI less than 0.56 was revealed.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Transvaginal colour Doppler ultrasound in normal and abnormal early pregnancy. 220 Aug 63

Between September 1981 and August 1987, 242 cases of suspected ectopic pregnancy were admitted to Tikur Anbessa Teaching Hospital, Addis Ababa, Ethiopia, of which 231 were confirmed at laparotomy. Over the same period of time 28,600 deliveries were conducted in the same hospital, giving a ratio of eight ectopic pregnancies to 1,000 deliveries. Review of the 176 cases records which could be retrieved revealed that 57.9% were in the age group of 20-29 years and 27% were nulliparous. The history revealed lower abdominal pain in 98.8%, amenorrhoea in 82.9% and vaginal bleeding in 73%. On clinical examination, 92% had lower abdominal tenderness, 80.6% cervical excitation tenderness, 26.7% a mass in the adnexa and 31.2% a haemoglobin level of 7 gm percent or less. In 51.7% of the cases the ectopic was on the right and in 44.4% on the left. In 37.5% of the cases more than 1,000 millilitres of blood was contained in the peritoneal cavity. Only two were cases of unruptured ectopic pregnancy. There were 5 (2.8%) cornual and 2 (1.1%) ovarian pregnancies. Culdocentesis was the most reliable diagnostic test. In the 176 cases, repeat ectopic occurred in 7.3%. In a situation like ours, where adequate diagnostic facilities are not available, ectopic pregnancy should always be suspected in women with lower abdominal pain and amenorrhoea, or lower abdominal pain and irregular vaginal bleeding.
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PMID:Ectopic pregnancy at Tikur Anbessa Hospital, Addis Ababa, Ethiopia, 1981-1987: a review of 176 cases. 220 78

In 2115 women seeking voluntary termination of pregnancy after 49 days of amenorrhea or less, we studied the effect of a single 600-mg dose of mifepristone (RU 486), followed 36 to 48 hours later by the administration of one of two prostaglandin analogues, either gemeprost (1 mg by vaginal suppository) or sulprostone (0.25, 0.375, or 0.5 mg by intramuscular injection). The women were monitored for four hours after prostaglandin administration. Efficacy was indicated by the complete expulsion of the conceptus without the need of an additional procedure. All other results were considered failures, and the pregnancy was then terminated by a surgical method. The overall efficacy rate was 96.0 percent (95 percent confidence interval, 95.0 to 96.8). The failures included persisting pregnancies (1.0 percent), incomplete expulsions (2.1 percent), and the need for hemostatic procedure (0.9 percent). The mean time to expulsion was significantly shorter when sulprostone was given in the high dose (4.5 hours) than when it was given in the two lower doses (13.1 and 19.3 hours) or when gemeprost was given (22.7 hours). The mean duration of uterine bleeding was 8.9 days (range, 1 to 35); one woman received a blood transfusion. Most women had transient abdominal pain after receiving prostaglandin, but there were few other side effects. We conclude that the administration of mifepristone followed by a small dose of a prostaglandin analogue is an effective and safe method for the early termination of pregnancy.
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PMID:Voluntary interruption of pregnancy with mifepristone (RU 486) and a prostaglandin analogue. A large-scale French experience. 230 93

To guide clinical judgements regarding possible pregnancy in women seen for nonpregnancy concerns, 75 pregnant women tested for pregnancy confirmation were compared to 31 women with pregnancies diagnosed when tested to clarify undifferentiated symptoms. Symptom clarification patients were more often unmarried (74.2% vs 37.3%, P less than 0.001), unemployed (54.8% vs 14.7%, P less than 0.0001), uninsured (54.8% vs 25.3%, P less than 0.004), black (67.8% vs 45.3%, P less than 0.04), using contraception (45.2% vs 22.7%, P less than 0.02), and carrying unwanted gestations (77.4% vs 34.7%, P less than 0.0001). Symptom clarification patients had a median 2 pregnancy symptoms versus 3 for pregnancy confirmation patients (P less than 0.001), less often reported amenorrhea (25.8% vs 6.7%, P less than 0.01) or breast tenderness (38.7% vs 66.7%, P less than 0.01), but more often experienced abdominal pain (45.2% vs 17.3%, P less than 0.003). Thus, symptom clarification patients are often earlier in gestation with fewer pregnancy symptoms, or may differ in how they perceive and interpret such symptoms when present, findings consistent with a tentative hypothesis that symptom clarification patients may not have anticipated being pregnant.
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PMID:The unanticipated pregnancy: a preliminary study. 234 87

The beginning of sex life is occurring at an ever younger age in industrial countries with the result of frequently unexpected and unwanted pregnancies. In primitive societies puberty starts later because protein-rich nutrition is lacking. The recommendation of contraceptive methods for young people in Western countries serves the same purpose of lengthening the period until sexual maturity. The extent to which contraceptive methods influence the menstrual cycle of young women depends on the level of maturity of their cycle: IUDs and hormonal contraceptives affect it, but natural methods do not. Barrier methods do not influence it either, but the condom promoted against AIDS is not reliable enough as a contraceptive. The intrauterine pessary is rarely used owing to the increased risk of genital inflammation. Effects on the cycle produce symptoms of stronger and longer bleeding and amenorrhea possibly linked to coagulation. In animal experiments corpus luteum insufficiency was demonstrated. Hormonal contraception is also the safest for young people. The degree of the suppression of the gonadal axis depends on the dose of the components and the chemical structure of the gestagens used as well as on the endocrine maturity level and ovarian susceptibility of the user. The so-called postpill amenorrhea does not occur more often than secondary amenorrhea in the general population. When using micropills sufficient suppression of the gonadal axis has to be watched, otherwise clinical symptoms of delayed ripening of the ovaries develops with additional endogenic estrogen secretion: lower abdominal pain, breast complaints, and bleeding disorders. The longterm effect of increased estrogen concentrations is characterized by oligomenorrhea and corpus luteum insufficiency in the menstrual cycles of young women.
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PMID:[Contraception for adolescents and its effect on menstruation]. 238 9

Maternal serum levels of human chorionic gonadotrophin (hCG), Schwangerschaftsprotein 1 (SP1) and pregnancy-associated plasma protein A (PAPP-A) were measured in an unselected group of 624 women presenting with amenorrhoea and vaginal bleeding with or without abdominal pain to an emergency gynaecological ultrasound clinic. Abdominal sector scanning was used to assess uterine contents. Pregnancy was confirmed by ultrasound in 406 pregnancies. Histological confirmation was obtained in each case of pregnancy failure. A live fetus was demonstrated in 259 women of whom six subsequently miscarried; one of these had markedly depressed serum hCG and PAPP-A, but normal SP1 levels, and two had oligohydramnios. Of the 147 women without ultrasound evidence of fetal heart action 67 had a correct ultrasound diagnosis of anembryonic pregnancy. The predictive value of a depressed serum hCG level was 70% in this group, and 31% in samples taken at less than or equal to 7 weeks. The predictive value of a normal hCG level was 96%. In 34 women missed miscarriage was diagnosed readily by ultrasound; all but five had depressed hCG and PAPP-A levels. A clinical diagnosis of a complete or incomplete miscarriage was made in 45 women and easily confirmed by ultrasound. All of them had depressed hCG, SP1 and PAPP-A levels. These results indicate that the diagnostic value of ultrasound in threatened miscarriage is often better than that of biochemical tests.
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PMID:Ultrasound and circulating placental protein measurements in complications of early pregnancy. 248 Jan 55

Are reported the results obtained with mifepristone, administered alone or followed by a low dose of prostaglandin derivative, as an alternative to endometrial aspiration for termination of early pregnancy. Mifepristone was first used alone in doses of 600 mg in 1,841 women. Subsequently, 703 other women received, 36 to 48 hours after mifepristone, either sulprostone (a prostaglandin E2 analogue) 0.25 mg intramuscularly, or gemeprost (a prostaglandin E1 analogue) 1 mg as pessary, or meteneprost (a prostaglandin E2 analogue) 10 mg as pessary. Mifepristone administered alone was successful in 80 per cent of pregnant women with less than 42 days of amenorrhoea. The mifepristone-prostaglandin combination was successful in more than 95 per cent of pregnant women with less than 50 days of amenorrhoea. Expulsion of the ovum was difficult to date when mifepristone was used alone; it occurred within 24 hours of prostaglandin dosing in more than 80 per cent of the other women. Uterine bleeding was almost constant. It was more copious than the usual menses in the majority of women, with or without prostaglandin, and it sometimes required aspiration or curettage (mifepristone alone 1.3 per cent, with prostaglandin 0.28 per cent) and/or blood transfusion (mifepristone alone 0.4 per cent, with prostaglandin 0.14 per cent). Administered alone, mifepristone was very well tolerated. When prostaglandin analogues were added the women complained of lower abdominal pain which required a minor antalgic treatment in 30 to 50 per cent of the cases. Gastrointestinal side-effects were mild, probably due to the low doses of prostaglandin administered.
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PMID:[Use of mifepristone in the termination of early pregnancy. The experience in France]. 252 50

Ovarian function was suppressed with 30 mg of medroxyprogesterone acetate, daily for 6 months, in 22 women with lower abdominal pain due to pelvic congestion. There was reduction in pelvic congestion demonstrated by venography in 17 of the 22 women, and in 16 this was associated with induction of amenorrhoea which suggests that effective ovarian suppression is an important component of successful treatment. In the 17 women who showed a reduction in venogram score, the median change in pain score was 75% compared with only 29% in the five women with no change in venogram score (P less than 0.01). This significant association between reduction in pelvic congestion and pain indicates that pelvic congestion is likely to be the cause of pain in these women and that treatment with medroxyprogesterone acetate could be of value.
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PMID:Medroxyprogesterone acetate in the treatment of pelvic pain due to venous congestion. 253 10

A young woman with acute intermittent porphyria is described. She was admitted in a prolonged attack and had developed a flaccid quadriplegia. During the course she showed various manifestations of the autonomic nervous system, including pupils, gastrointestinal tract, cardiovascular system and others. On admission her pupils were equally mydriatic, and reacted to light sluggishly. Dilation of the pupils was seen when cocaine was instilled, but not when adrenalin. It was suggested that the parasympathetic control of pupils was disturbed. She complained repeatedly abdominal pain, nausea, vomiting, and constipation. However, diarrhea was rarely found. Radiological examinations revealed that her bowel movements were markedly impaired. Sinus tachycardia and elevation of blood pressure were frequently observed with attacks, and they correlated with the clinical course. With tachycardia the coefficient variance of R-R interval was markedly decreased, and large dose of atropine failed to accelerate the heart rate. These indicate that the vagal function was markedly impaired with attacks. The effects of isoproterenol and of propranolol on the heart rate were normal. Phenylephrine and phentolamine changed the blood pressure normally. From these it was concluded that the sympathetic nervous function was not so impaired at the time examined. However, with the elevation of blood pressure plasma and urinary noradrenaline were markedly increased. Other autonomic and related manifestations observed during the course included disorders of sweating, loss of sphincter control, fever of unknown cause and amenorrhea.
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PMID:[Autonomic dysfunctions in acute intermittent porphyria]. 258 92

Twenty-four cases of intrauterine adhesions (Asherman's syndrome) were reported. The characteristic clinical picture was amenorrhea of hypomenorrhea accompanied by periodic lower abdominal pain. Intrauterine adhesions were demonstrated by hysterography in 14 cases. Lysis of adhesions was performed in 14 patients through vaginal route and in 3 by abdominal hysterotomy. Cyclic abdominal pain disappeared after treatment in all patients and normal menses were established in 16 cases (94%). In 11 patients with intrauterine adhesions developing after trauma, 3 conceived for 4 times all resulting in full term deliveries of healthy babies. The etiologic factors method of diagnosis and treatment of intra-uterine adhesions and prevention of readhesion are discussed.
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PMID:[Diagnosis and treatment of intrauterine adhesions]. 262 May 82


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