Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000729 (abdominal cramps)
 531 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Opiate addicts receiving nonmethadone, symptomatic, chemotherapeutic treatment for the abstinence syndrome (at Terros' Opiate Detoxification Program), complained of pains that appeared unrelated to abstinence. The pains reported were primarily lumbosacral pains, joint pains, abdominal cramps, and muscle cramps in the lower extremities. Admission laboratory tests on 150 addicts were used in an attempt to correlate the blood chemistry with the type of pains described. Results of this preliminary screening indicate that a high uric acid level and a low blood urea nitrogen (BUN) may be related in females with joint pains and males with lumbrosacral pains. Values obtained from the nomogram indicate that all addicts have less than 50% of the total serum calcium in ionized form, and the low serum ionized calcium content is associated with abdominal and muscle pains, although 72% of all the addicts studied were within the 3.5 to 4.0 mg range. Hyperproteinemia, low BUN, high uric acid, and low serum ionized calcium were the most significant of the blood chemistry values. Blood glucose levels were not included due to the fact that test were not necessarily fasting results.
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PMID:Hematologic abnormalities and pain during acute opiate abstinence syndrome. 67 42

A 27 years old woman was admitted due to abdominal cramps, jaundice and oligoanuria, starting 48 hours after eating Chinese food. Hepatic biochemical tests, abdominal ultrasound and retrograde pyelography were normal. The urine was intensely orange colored and microscopic analysis was normal. The serum creatinine and urea nitrogen on admission were 4.59 and 42.5 mg/dl and rose to 13.5 and 72.4 mg/dl, respectively, at the 6th hospital day. Oliguria lasted only 48 hours. Dialysis was not used, since the patient was in good general condition and uremic symptoms were absent. On the 7th day, azotemia began to subside and at the 14th day, serum creatinine was 1.0 mg/dl. Before hospital discharge, she confessed the ingestion of 2.000 mg of phenazopyridine, during a nervous breakdown, aiming to sleep deeply. Remarkable was the persistence of the orange color of her urine during several days and the dissociation between the rate of increase of serum creatinine with respect to urea nitrogen. This is an unusual case of acute renal failure caused by an overdose of a drug, commonly prescribed for urinary tract infections.
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PMID:[Acute renal failure caused by phenazopyridine]. 1287 16