Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000729 (abdominal cramps)
 531 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The first reported case of simultaneous tubal and intrauterine pregnancy in a woman with an IUD is situ is presented. The incidence of combined pregnancies is estimated as 1 to 2/10.000 gestations. The risk of IUD users to have combined tubal and intrauterine pregnancy is calculated is 1/6,000,000 women years of use. A 32-year old patient, gravida 3, para 2 was admitted because of threatened miscarriage in the first trimester. she had been wearing an IUD for 2 1/2 years. Her symptoms were vaginal bleeding and abdominal pain. Pelvic examination showed an enlarged uterus consistent with a pregnancy of 12 weeks' gestation. A vacuum extraction was performed revealing a Copper-T IUD and intrauterine gestation. In the following days she experienced recurrent abdominal cramps and her physical condition did not improve. The red cell sedimentation test remained slightly elevated. 19 days after the evacuation she still had vaginal bleeding and the pregnancy test was still positive. Pelvic examination now disclosed a right, tender adnexal mass the size of a fist. By laparotomy a ruptured right-sided tubal pregnancy was found surrounded by an organized hematoma containing the right ovary. A right salpingo-oophorectomy was performed after microscopic proof of the existence of tubal pregnancy. The patient with combined pregnancy usually presents symptoms that do not facilitate the diagnosis of this specific disease. The diagnosis may be secured by careful pelvic examination, serial ultra-sound scanning, or eventually laparoscopy.
 ...
PMID:Heterotopic pregnancy. The first case with an IUD in situ. 231 94

Information from animal studies has demonstrated the harmful effects of zinc supplementation on copper transport. Although some studies have been carried out in humans, the effect on humans has not been as well documented as the effect on animals. Forty-seven healthy volunteers (26 women and 21 men) took part in a double-blind cross-over trial which lasted for 12 weeks. The subjects were asked to take 50 mg of elemental zinc (as 220 mg zinc sulphate) or placebo, three times a day for six weeks. Venous blood was collected for the analysis of plasma levels of copper and zinc. Symptoms, which included headaches, abdominal cramps, nausea, loss of appetite and vomiting, were registered from 84% of women and 18% of men. Six female volunteers discontinued the trial; five owing to gastric irritation and one owing to consistent headaches. Plasma zinc levels rose significantly in both men and women, the increase being 36% and 57%, respectively. Plasma copper levels did not change significantly. Our study suggests that the gastric discomfort that is associated with zinc supplementation may be related to body weight as symptoms were reported from the lower-weight volunteers. Our study also shows no detrimental effect of 150 mg of zinc a day on plasma copper levels in healthy volunteers over a period of six weeks.
 ...
PMID:The effect of zinc supplements on plasma zinc and copper levels and the reported symptoms in healthy volunteers. 354 53

This article summarizes two investigations that examine the health effects of prolonged exposure to copper-contaminated drinking water. The first study was initiated after elevated copper levels were detected in several homes that were either newly constructed or recently remodeled. All of these homes were served by the same municipal water supplier. The second case involved illnesses and water-quality problems that were reported by several residents of a mobile home park shortly after a new water distribution system was installed. Findings from these investigations suggest that copper-contaminated drinking water may be a fairly common cause of nausea, diarrhea, abdominal cramps, and headaches-especially among residents of new or recently-remodeled homes, and in areas where water supplies are naturally corrosive.
 ...
PMID:Gastrointestinal upsets and new copper plumbing--is there a connection? 944 8

During 1992 and 1993 the Wisconsin Division of Health investigated five cases in which copper-contaminated drinking water was suspected of causing gastrointestinal upsets. Each of these case studies was conducted after our office was notified of high copper levels in drinking water or notified of unexplained illnesses. Our findings suggest that drinking water that contains copper at levels above the federal action limit of 1.3 mg/l may be a relatively common cause of diarrhea, abdominal cramps, and nausea. These symptoms occurred most frequently in infants and young children and among resident of newly constructed or renovated homes.
 ...
PMID:Gastrointestinal upsets associated with ingestion of copper-contaminated water. 973 10

29 patients received meptazinol 100 mg and 30 received placebo in a randomized double-blind study of the efficacy of meptazinol for the relief of pain following insertion of a Copper 7 IUD. 55 nulliparas and 4 oligoparas aged 18-35 undergoing a 1st insertion of IUD were fitted with Cu 7 devices following standard procedures. Each patient received 50 tablets of either meptazinol 100 mg or placebo and 50 tablets of paracetamol to be used as rescue therapy if they felt the trial therapy was ineffective. Patients were asked to record presence or absence of abdominal cramps and other symptoms and to return for follow-up in 7 days. There were no significant weight or parity differences between the 2 groups. There was no significant difference in the IUD side-effects index in patients taking meptazinol or placebo and in those resorting to rescue therapy. Meptazinol scored better than placebo in an assessment of overall quality of treatment. The patients who used meptazinol as initial therapy did so on 66 separate occasions and resorted to secondary therapy on 19 occasions, while the patients who used placebos as initial therapy did so on 80 occasions and resorted to the secondary therapy on 33 occasions. The trends appear to have clinical significance but did not reach statistical significance. Adverse effects were minor and similar in both groups, indicating that meptazinol is a safe drug for the treatment of IUD pain.
 ...
PMID:Treatment of pain following IUD insertion with meptazinol--a new centrally acting analgesic. 1226 14