Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000729 (abdominal cramps)
 531 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The medical management of early unruptured tubal ectopic pregnancies is gaining acceptance internationally as an alternative to surgical procedures. This method has been shown to be effective and safe in properly selected cases and with adequate supervision. Most of the work however has been done using either methotrexate or prostaglandins. The present study aimed to evaluate the efficacy of a combined therapeutic regimen. The efficacy was noted to be at least as good but with fewer side-effects. The treatment was effective in 18 out of 19 cases of tubal pregnancies (94.7%). One patient complained of a gastritis which resolved with antacids. One patient experienced abdominal cramps and transient hypotension probably as a profound vagal response during tubal abortion. The median time to resolution varied directly with the initial serum beta HCG level at diagnosis. All patients who responded to the therapy described the experience as painless and viewed the treatment positively as it spared them the need for surgery and its attendant anaesthetic risks. However, we strongly recommend caution and close supervision and to keep the patient in the hospital at least for the first week of therapy.
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PMID:Combined chemotherapy in the medical management of tubal pregnancy. 871 74

To correlate the position and orientation of different models of MLCu IUDs in utero with incidence of side effects, 35 married, nonlactating, and sexually active women, 18-24 years of age and with regular menstrual periods were studied. All had been pregnant at least once and had had at least 3 menstrual periods after the last delivery or 2 periods after the last abortion. A physical and gynecological examination was performed. The women were divided into 4 groups: 30 women (3 groups of 10 patients) were fitted with standard MLCu 250, short MLCu 250, and MLCu 375 IUDs. The 4th group consisted of 5 women in whom MLCu 250 mini was inserted. Menstrual blood loss collected in cotton pads of constant weight provided by the investigator. The women were carefully instructed on how to collect their menstrual blood, and polyethylene bags were supplied to them. Menstrual blood loss was calculated. Follow-up visits were planned at monthly intervals, and questions about side effects were asked. In 30 women hysterography was done twice. Initially, it was performed following the 1st postinsertion menstruation. A 2nd hysterogram was performed following the 3rd postinsertion menstruation. The IUD was properly oriented in utero in 20 cases (67%). These were fitted with short MLCu 250 (8 cases), MLCu 375 (6 cases), Standard MLCu 250 (4 cases), and mini MLCu 250 (2 cases). The other 2 patients had small uterine cavities fitted with mini devices. Device displacement was noted in 10 cases among those fitted with MLCu 250, Standard (2 cases), MLCu 250 mini (3 cases), MLCu 375 (2 cases). Subjective increased menstrual blood loss was reported in 11 cases. There was no significant difference between pre- and postinsertion menstrual blood loss. Intermenstrual bleeding was reported in 3 cases, 1 fitted with a short MLCu 250 and 2 cases fitted with MLCu 375. Hysterographically the device was properly oriented in 2 cases with a large uterus. 5 cases had a moderate degree of dysmenorrhea, 1 case fitted with short MLCu 250, 3 cases with standard MLCu 250, and 1 case with MLCu 375. Hysterographically the device was displaced in utero in 2 cases, and most of the cases had a large size uterus. All these patients experienced no dysmenorrhea prior to IUD insertion. Moderate deep seated pelvic pain and low abdominal cramps were experienced in 3 cases, a case in each group of those fitted with different models of MLCu 250. Pain was not reported in patients fitted with MLCu 375.
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PMID:Hysterographic orientation of IUDs in relation to menstrual blood loss. 1226 65

Threatened miscarriage, as demonstrated by vaginal bleeding with or without abdominal cramps, is a common complication of pregnancy. It occurs in about 20% of recognised pregnancies. Risk of miscarriage is increased in older women and those with a history of miscarriage. Low serum levels of progesterone or human chorionic gonadotrophin (hCG) are a risk factor for miscarriage. Other risk factors include heavy bleeding, early gestational age and an empty gestational sac of >15-17 mm diameter. Clinical history and examination, maternal serum biochemistry and ultrasound findings provide valuable information about the prognosis and are important to establish in order to determine potential treatment options. Although bed rest is the most common choice of treatment, there is little evidence of its value. Other options include luteal support with progesterone, dydrogesterone or hCG. There is some evidence from clinical studies indicating that progesterone or dydrogesterone may reduce the rate of miscarriage, although further data from double-blind, randomised-controlled trials are necessary to confirm efficacy.
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PMID:Treatment options for threatened miscarriage. 1994 36

Caesarean scar ectopic pregnancy (CSEP) is one of the rarest forms of ectopic pregnancies. With rising caesarean delivery (CD) rates worldwide, there is an increase in the incidence of CSEP. Patients usually present with painless vaginal bleeding and often misdiagnosed as spontaneous miscarriage. The use of ultrasonography with colour flow Doppler helps in the differential diagnosis. Different treatment options are described in the literature, although there is insufficient evidence regarding the best approach. We report the diagnosis and management of a case of CSEP in a woman with four previous CD who presented with vaginal bleeding and lower abdominal cramps at six weeks of gestation. She was treated with laparoscopic and ultrasound guided aspiration of the gestational sac and local injection of methotrexate supplemented by intramuscular methotrexate injection.
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PMID:A Combination of Surgery and Methotrexate for Successful Treatment of a Caesarean Scar Pregnancy. 3052 Feb 79


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