Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0000727 (acute abdomen)
 3,084 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Authors present the third case of small-bowel perforation of a metastatic sarcomatoid carcinoma of the lung. A 62-year-old man underwent a right upper lobectomy because of a lung tumour infiltrating the posterior thoracic wall. The histology showed pleomorphic subtype of a sarcomatoid carcinoma (pT3 pN0 cM0). The postoperative course was uneventful and thus the patient received 5 000 cGY over five weeks. After 5 months the patient was admitted to the Surgical Department for acute abdomen. At laparotomy an advanced fibrinous, bile-stained peritonitis secondary to a solitary perforation of the jejunum 50 cm distal to the Treitz were observed. The microscopical examination showed that the perforated mass consisted of infiltration of dischoesive malignant giant cells, highly pleomorphic multi and mononucleated. The immunohistochemistry, performed with multiple keratin antibodies, revealed epithelial differentiation of malignant cells, compatible with a metastatic carcinoma, consistent to the lung primary. In conclusion, according with literature, the small-bowel perforation is a rare presentation of a metastatic lung carcinoma, and particularly of a sarcomatoid carcinoma. It should be considered in differential diagnosis of patients with acute abdominal symptoms especially in those with a previous treated lung cancer. The surgeons should be aware of the poor outcome of these patients and choose a palliative treatment.
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PMID:Jejunal perforation secondary to metastatic sarcomatoid carcinoma of the lung. 1831 94

We report 2 cases of pancreatic cancer discovered incidentally in the wake of acute abdomen from other causes. Case 1 is a 67-year-old man who was referred to our hospital in October 2010 for the treatment of an incarcerated right inguinal hernia. The hernia was manually reduced, and mesh plug hernioplasty was scheduled for the next day. A 2.9 cm diameter tumor was detected in the tail of the pancreas on plain CT at the first visit and confirmed on enhanced CT soon after the hernia repair. A follow-up abdominal CT scan approximately 1 month later showed modest enlargement of the tumor to 3.5 cm diameter. The patient underwent distal pancreatectomy with lymph node dissection in December 2010. The histopathological diagnosis was tubular adenocarcinoma(tub1>tub2). Comprehensive findings were pT2, pN0, cM0, fStage II . He was treated with adjuvant chemotherapy consisting of gemcitabine 1,000mg/m2 for 6 months after surgery, and at 5 years and 7 months after surgery, he was alive and recurrence-free. Case 2 is a 74-year-old man who presented to our hospital with lower abdominal pain and diarrhea in early January 2016. Colonoscopy and barium enema revealed severe stenosis of the rectum(Rs). Rectal biopsy confirmed adenocarcinoma of the rectum. In addition, an enhanced CT scan showed irregular dilatation of the pancreatic duct in the pancreatic tail. The patient underwent low anterior resection and distal pancreatectomy, which was performed following an intraoperative pancreatic ultrasound examination that supported a diagnosis of pancreatic cancer. Pathological and comprehensive findings of rectal cancer were tubular adenocarcinoma(tub2)and pT3, pN0, cM0, fStage II , and those of the pancreatic cancer were tubular adenocarcinoma(tub2)and pT1, pN0, cM0, fStage I . The patient was discharged from the hospital 46 days after surgery. However, he died 18 days later due to sudden out-of-hospital cardiopulmonary arrest.
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PMID:[Two Cases Pancreatic Carcinoma Detected Incidentally during Treatment of Acute Abdomen from Other Causes]. 2813 91