Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000727 (acute abdomen)
 3,084 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Drug-induced acute pancreatitis should be in the differential diagnosis of acute abdomen occurring soon after initiation of tuberculosis treatment and chemoprophylaxis. Isoniazid-induced pancreatitis is potentially reversible; early recognition and drug withdrawal are warranted in the appropriate clinical setting. We present a case of reversible acute pancreatitis after isoniazid treatment of genitourinary tuberculosis, followed by recurrence of pancreatitis 12 years later when the patient received isoniazid again for pulmonary tuberculosis. Isoniazid-induced pancreatitis, if highly suspicious or confirmed with re-challenge test, mandates permanent avoidance of the drug.
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PMID:Recurrent acute pancreatitis after isoniazid. 1536 3

Drug-induced acute pancreatitis should be considered in the differential diagnosis of acute abdomen occurring soon after the initiation of antitubercular treatment. Isoniazid-induced pancreatitis is potentially reversible: early recognition and drug withdrawal are warranted in the appropriate clinical setting. We present a case of reversible acute pancreatitis after isoniazid treatment of lymph node tuberculosis, followed by the recurrence of pancreatitis upon the reintroduction of the drug.
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PMID:Isoniazid-induced recurrent acute pancreatitis. 2187 3