Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0000727 (
acute abdomen
)
3,084
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening adverse drug reaction characterised by generalised skin rash, fever, lymph node enlargement and haematological abnormalities, in addition to multiorgan involvement. However, diagnosis can be challenging, with rare cases presenting as an
acute abdomen
.Its aetiopathogenesis is not fully understood but inefficient drug detoxification, deregulated immune responses, reactivation of host viruses and genetic predisposition appear to be important. Furthermore, it has been recently recognised that antibiotics may act as promoters of
DRESS syndrome
caused by another drug. We report the case of a 48-year-old man, receiving allopurinol, who developed
DRESS syndrome
, initially presenting with a cholecystitis-like
acute abdomen
that was triggered by antibiotics. This report also emphasises the utility of performing patch skin tests to establish drug imputability.
...
PMID:Allopurinol-induced DRESS syndrome presented as a cholecystitis-like acute abdomen and aggravated by antibiotics. 3004 9
