Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000727 (acute abdomen)
 3,084 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Phlegmonous enteritis is a rare inflammatory bowel disease. A 52-yr-old man with a history of alcoholic abuse was admitted to the hospital for an acute abdomen and died of septicemia and its complications. Autopsy revealed phlegmonous inflammation of the ileum and severe fatty liver. Numerous Gram-negative rod bacilli were demonstrated in the ileal mucosa. Shortened villi and decreased lysozyme activity of Paneth cells in the small intestine might be results of chronic alcohol ingestion. The relationship between phlegmonous enteritis and alcoholic abuse was strongly suggested in this case.
 ...
PMID:Phlegmonous enteritis in alcoholic fatty liver. 192 52

Among the primary malignant tumours of the spleen, fibrous histiocytoma (MFH) is extremely rare and only six cases have been reported in the literature. A splenectomy was carried out in a 22-year-old woman presenting with an acute abdomen. Imaging procedures showed a 5 cm round, heterogeneous mass in the spleen. At light microscopy the infiltrating cell population was arranged in nests or bundles with a storiform pattern. At higher magnification, most neoplastic elements were medium-sized, round or spindle-shaped, with acidophilic cytoplasm and oval or round nucleus. Mitotic figures were numerous; reactive foamy macrophages could be seen. At immunohistochemistry, in paraffin sections, there was strong positivity with the reagents against CD45, CD68, alfa-1-antichymotrypsin and vimentin. In frozen sections there was a clear-cut positivity with the antibodies EBM11 (CD68), KP1 (CD68), Ber Mac 3, anti-lysozyme and anti-vimentin. The case reported revealed morphological and immunohistochemical features consistent with MFH, of the storiform-pleomorphic variant. The clear-cut positivity for macrophage-associated molecules and for leucocyte common antigen would seem to suggest a histiocytic origin. MFH is considered an aggressive tumour, with a frequent recurrence and metastasis but our patient is alive and free of disease three years from surgery.
 ...
PMID:Malignant fibrous histiocytoma of the spleen - report on a case presenting as emergency. 2160 49