Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0000727 (
acute abdomen
)
3,084
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cyclical vomiting syndrome
(
CVS
) is a functional, debilitating disorder of childhood frequently leading to hospitalization. Affected children usually experience a stereotypical pattern of vomiting though it may vary between different individuals. The vomiting is intense often bilious, and accompanied by disabling nausea. Identifiable precipitating factors for
CVS
include psychosocial stressors, infections, lack of sleep and occasionally even food triggers. Often, it may be difficult to distinguish episodes of
CVS
from other causes of
acute abdomen
and altered consciousness. Thus, the diagnosis of
CVS
remains largely one of exclusion. Investigations routinely done during the work-up of a child with suspected
CVS
include both blood and imaging modalities. Plasma lactate, ammonia, amino acid and acylcarnitine profiles as well as urine organic acid profile are indicated to exclude inborn errors of metabolism. The treatment remains challenging and targeted at prevention or shortening of the attacks and can be considered as abortive, supportive and prophylactic. Use of non-pharmacological therapy is also part of the management of
CVS
. The prognosis of
CVS
is variable. More insight into the pathogenesis of this disorder as well as role of non-pharmacological therapy is needed.
...
PMID:Cyclical vomiting syndrome: Recognition, assessment and management. 2525 85
