Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0000727 (acute abdomen)
 3,084 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a 26-year-old patient admitted to the emergency ward with acute abdomen, all the symptoms--nausea, vomiting, indeterminate abdominal pain, constipation, renal failure, polyuria and polydipsia--could be explained by calcium intoxication syndrome. Investigation revealed generalized sarcoidosis. Under medical treatment with prednisone all the pathologic findings rapidly regressed. The pathogenesis of hypercalcemia in sarcoidosis, and particularly the disorder of vitamin D metabolism with raised levels of 1,25-dihydroxycholecalciferol, are discussed.
 ...
PMID:[Acute hypercalcemia syndrome in sarcoidosis]. 384 Sep 13

Splenic artery aneurysms are very rare causes of acute abdomen but are important to recognize since they carry high rate of mortality when ruptured. The aim of this study was to present a middle aged man with sudden onset of abdominal pain. Being previously on steroid treatment due to sarcoidosis, the patient developed hypovolemic shock during work-up in diagnostic imaging and went on emergency laparatomy. The source was identified as a ruptured splenic artery aneurysm. Splenectomy en bloc with the aneurysmatic distal splenic artery was performed, and he was discharged uneventfully. Despite rare, it is important to recognize splenic artery aneurysm in the emergency department, and immediate intervention is required to save the patient.
...
PMID:Spontaneous rupture of the splenic artery aneurysm: a rare clinical presentation of acute abdomen. 2713 88

Sarcoidosis is a chronic inflammatory multisystem disease. The stomach is the most commonly involved gastrointestinal organ. Symptomatic appendicular sarcoidosis is extremely rare. We present a case of a 49-year-old woman with abdominal pain. An ultrasound of the abdomen was suggestive of acute appendicitis. Laparoscopic appendectomy was performed and the pathology revealed nonnecrotizing granulomas. Biopsy of the mediastinal lymph nodes suggested noncaseating granulomas. She was treated with steroid therapy followed by mycophenolate mofetil. Our case demonstrates the importance of considering appendiceal sarcoid among the differentials in a patient with systemic sarcoidosis presenting with an acute abdomen.
 ...
PMID:Appendiceal sarcoidosis presenting as acute appendicitis. 3267 57