Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: KEGG:D06522 (
Silica
)
2,396
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In the present study, copper-based (25 - x)CaO - xCuO -10P
2
O
5
- 5B
2
O
3
- 60SiO
2
(x = 2.5, 5, 7.5, 10 mol%) mesoporous bioactive glasses (MBGs) were synthesized using the sol-gel technique with cetyltrimethyl ammonium bromide as the structure-directing agent. The live-dead cell count and cytocompatibility of MBGs for J774A.1 murine macrophages have also been investigated for different concentrations of MBGs. The ionic dissolution profile for Ca, P and Si has been evaluated in the simulated body fluid. The effect of copper content as well as the ionic dissolution products on the up-regulation and down-regulation of
TGIF
-2, HDAC-4, Smurf-1, mir-30c and mir-130a genes for the murine model are investigated using reverse transcription-polymerase chain reaction.
Silica
and calcium release follows a similar trend as followed by gene up-regulation of
TGIF
-2, HDAC-4 and mir-30c genes. This indicates that silica and calcium release influence gene expression.
...
PMID:Effect of copper on the up-regulation/down-regulation of genes, cytotoxicity and ion dissolution for mesoporous bioactive glasses. 2879 64
