Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D06522 (Silica)
 2,396 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A rapid and specific high-performance liquid chromatography assay of lamotrigine in human plasma is described. Lamotrigine is extracted with dichloromethane from buffered plasma to which an internal standard has been added. The solvent is directly injected into a 250 x 4.6-mm Spherisorb Silica column and the drug is eluted by using a mixture of methanol, n-heptane, dichloromethane, and 28-30% ammonium hydroxide (20:40:40:0.3 vol/vol) at a flow rate of 1 ml/min. The eluates are detected at 240 nm. The assay requires 250 microliters of sample, and concentrations as low as 0.4 microgram/ml can be measured accurately. The method is linear in the range of 0.4-16 micrograms/ml, with a mean coefficient of correlation (r) > or = 0.997. Within- and between-day relative standard deviations at three different concentration levels (1, 4, and 8 micrograms/ml) are < or = 8.6%.
Ther Drug Monit 1997 Feb
PMID:A rapid and specific assay for the determination of lamotrigine in human plasma by normal-phase HPLC. 902 58

About 60,000 particles in 288 aerosol samples collected during farm work have been characterised with automated particle analysis using scanning electron microscopy (SEM) and energy dispersive X-ray spectrometry (EDS). Based on EDS-analysis of materials with known composition (potato flour, alpha-quartz, K-feldspar and beta-wollastonite), criteria were developed for classification of particles as: (1) organic, (2) silicon-rich (silica), and (3) other inorganic particles. The reproducibility of the relative mass proportions in dust samples collected during farm work was 0.078 when approximately 200 particles were characterised per sample. Field samples from the farm environment showed clear differences in composition. Generally, inorganic particles dominated the particle mass. The proportion of the organic particle mass was highest for tending of swine and poultry, 55 and 38% respectively. Silica particles amounted to 10 to 20% of the total mass during handling crops, e.g. grain, straw, hay, potatoes, and onions. It seems likely that the results can be used in etiologic studies, but further validation would be needed for quantitative purposes.
J Environ Monit 1999 Aug
PMID:Classification of particles from the farm environment by automated sizing, counting and chemical characterisation with scanning electron microscopy-energy dispersive spectroscopy. 1152 40

Municipal solid waste incineration (MSWI) is a straightforward way to manage waste, however the disposal of process byproducts, mainly bottom and fly ash, is still a problem, because of their hazardous contents. Fly ash is a byproduct of many other processes that involve combustion to produce energy. In this paper we present and discuss a new method for MSWI fly ash inertization, mainly based on the use of colloidal silica as a stabilization agent for metals. In the patented procedure, fly ash of different provenance can be used to produce an inert and non-hazardous material, that can be reused. In fact to make the recovery process more efficient, landfilling should be totally avoided. For this reason, to enhance the possibility of reuse, a washing process, for salts recovery, is proposed as a final step of the inertization procedure. The obtained inert material is called COSMOS (COlloidal Silica Medium to Obtain Safe inert), and it is composed of calcium carbonate, calcium sulfate, silicon oxide and a wide quantity of non-soluble amorphous compounds. COSMOS does not contain any corrosive salts. This makes it extremely interesting for cement industry applications with several other advantages, and environmental benefits. The new proposed inertization procedure appears very promising, because it allows MSWI fly ash to be considered a valuable resource. Thanks to the obtained results, a demonstration project, in the frame of LIFE+, has been funded by the European Commission (LIFE+ 2008 project ENV/IT/000434, ).
J Environ Monit 2010 Nov
PMID:A new method for municipal solid waste incinerator (MSWI) fly ash inertization, based on colloidal silica. 2095 31