Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D06522 (Silica)
 2,396 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Silica, a specifically toxic substance for macrophages, has been used to study the role of these cells in the Corynebacterium parvum-induced anti-tumour protection. In the two experimental tumours studied, silica, C. parvum and tumour cells were injected by the same route: the intravenous route in the case of lymphosarcoma in XVII mice and the intraperitoneal in that of mammary carcinoma in C3H mice. The inhibition of the anti-tumour effect of C. parvum by the administration of silica was more pronounced in C3H than in XVII mice. Silica administration has only a weak and transient depressive effect on the stimulation of macrophage phagocytic activity induced by C. parvum. In addition, silica injection increased the adjuvant effect of C. parvum on the sheep red blood cell antibody response. These results suggest that the silica induced abrogation of the anti-tumour effect of C. parvum could be due to a local inhibition of macrophage stimulation at the tumour inoculation site.
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PMID:[Effect of silica on the anti-tumour activity of "Corynebacterium parvum" (author's transl)]. 23 75

Combined immunostimulation with BCG and double-stranded polyinosinic-polycytidylic acid (poly I . poly C) was more effective than single-modality immunostimulation in suppressing tumor growth in inbred Swiss mice. BCG sensitization followed by administration of poly I . poly C on the day of tumor cell injection significantly prolonged the survival period against parental lymphosarcoma (LS) and its ascites variant (LS-A). BCG and poly I . poly C given together on the day of tumor cell injection suppressed only LS-A and not LS. BCG or poly I . poly C given alone did not result in tumor cures. Silica injection given 2 days before poly I . poly C injection completely abrogated the antitumor effect of sequential treatment with BCG and poly I . poly C. Silica treatment given on and beyond the day of poly I . poly C injection did not abrogate the antitumor effect. This observation indicated that intact macrophage effector function was essential at the time of tumor cell inoculation to obtain an effective antitumor action.
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PMID:Enhanced host resistance to transplantable murine lymphosarcoma in Swiss mice by combined immunostimulation with BCG and polyinosinic-polycytidylic acid. 658 93