Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D06320 (Vorinostat)
 355 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
histone deacetylase 176
histone 84
Histone deacetylase 67
HDAC 47
Mol 29
Sep 22
HDAC1 21
p53 18
HDAC6 18
p21 17
histone H3 15
insulin 14
HDAC2 11
caspase-3 10
Bcl-2 8
HDAC8 8
proteasome 8
cytokine 7
HDAC3 7
H2AX 7
TNF 6
mTOR 6
ERK 6
AKT 6
GSK 6
p27 6
proteasome inhibitor 6
cyclin D1 6
BOD 5
PC-3 5
ACS 5
SCH 5
Erythropoietin 5
caspase-8 5
CD4 5
Mcl-1 5
AML 5
RLN2 4
c-Myc 4
BET 4
more...
Disease
cancer 169
tumor 87
cutaneous T-cell lymphoma 70
tumor growth 26
breast cancer 20
lymphoma 16
thrombocytopenia 15
HIV 13
acute myeloid leukemia 12
glioblastoma 12
leukemia 11
multiple myeloma 11
MCF 10
hematologic malignancies 10
non-small cell lung cancer 9
carcinogenesis 8
tumorigenesis 7
lung cancer 7
B-cell lymphoma 6
glioma 6
malaria 6
carcinoma 6
SCH 5
neuroblastoma 5
T-cell lymphoma 5
mycosis fungoides 5
Hodgkin's disease 5
colorectal cancer 5
mantle cell lymphoma 5
prostate cancer 5
neutropenia 5
anemia 5
RTS 4
diabetes 4
Niemann-Pick 4
glioblastoma multiforme 4
solid tumor 4
melanoma 4
sarcoma 4
depression 4
more...
Symptom
fatigue 13
nausea 10
diarrhea 9
anorexia 8
vomiting 6
asthenia 2
dyspnea 1
decreased appetite 1
pain 1
syncope 1
seizures 1
lightheadedness 1
splenomegaly 1
Drug
Vorinostat 355
lysine 24
Sorafenib 23
Romidepsin 22
Bortezomib 21
Bevacizumab 17
Everolimus 17
Pegasys 16
Ezetimibe 15
Cetuximab 15
Denosumab 14
Gleevec 14
Pemetrexed disodium 14
Sunitinib malate 13
PMPA 13
G-CSF 12
Gefitinib 12
Rosuvastatin calcium 12
Tenofovir disoproxil fumarate 12
CIA 11
Lenalidomide 11
Pregabalin 11
Tarceva 11
Dasatinib 11
Bosentan 10
Duloxetine hydrochloride 10
Peginterferon alfa-2b 10
Adalimumab 10
Peginterferon alfa-2b 10
Mycophenolic acid 10
Aliskiren fumarate 10
Bosentan 10
Tocilizumab 9
Teriparatide 9
Darbepoetin alfa 9
Pimecrolimus 9
Exenatide 9
Epoetin 9
Pitavastatin calcium 8
Escitalopram oxalate 8
more...
Enzyme
ERK 13
proteasome 8
mitogen-activated protein kinase 8
GSK 6
ACS 5
caspase-3 5
luciferase 4
ACE 4
topoisomerase 4
cdc2 4
topoisomerase 4
focal adhesion kinase 4
catalase 3
MEK 3
caspase-8 3
PARP 3
alcohol dehydrogenase 2
phosphoinositide 3-kinase 2
lactate dehydrogenase 2
reverse transcriptase 2
ADH 2
protein kinase 2
aspartoacylase 1
demethylase 1
collagenase 1
delta-aminolevulinic acid dehydratase 1
CPT 1
protein kinase C 1
chaperonin 1
glucokinase 1
m-calpain 1
TMT 1
serine hydroxymethyltransferase 1
peroxidase 1
phosphodiesterase 1
alanine aminotransferase 1
CPT 1
CPT 1
guanylate cyclase 1
MDR 1
more...
Compound
DNA 53
Clin 28
lysine 27
Histone 23
sodium 22
Dec 18
MDA 13
salt 13
acetate 13
bromide 12
Aripiprazole 12
oxygen 12
5-Azacytidine 11
PEG 10
Paclitaxel 10
Amlodipine 9
potassium 9
zinc 8
5-Aza-2'-deoxycytidine 7
Rapamycin 7
Temsirolimus 7
Lopinavir 6
glucose 6
TNF 6
water 5
ACS 5
Tigecycline 5
ACS 5
DHA 4
PAN 4
acrylonitrile 4
Telmisartan 4
Linezolid 4
Voriconazole 4
NAD 4
phosphate 4
Daptomycin 4
MTT 4
Eplerenone 4
Emtricitabine 4
more...