Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D06103 (Theophylline)
 2,023 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
2'-phosphodiesterase 9.6
Histone deacetylase 2 8.9
HDAC2 protein 8.7
Cyclic nucleotide phosphodiesterase 8.4
NIDD 8.3
interferon alpha A 8.2
adenosine receptor 8.2
LPCAT2 8.2
Na+,K+ ATPase 8.2
cyclic nucleotide phosphodiesterase 8.1
cyclic AMP phosphodiesterase 7.9
pyridoxal kinase 7.8
NIPA 7.7
cystatin S 7.6
PDE4 7.5
Mullerian inhibiting substance 7.5
ubiquitin-conjugating enzyme E2 7.4
phosphodiesterase 7.3
HSM 7.2
EDN 7.2
Arylsulfatase A 7.1
ubiquitin-activating enzyme E1 7.1
histone deacetylase 2 7.0
IAR 7.0
L100 7.0
P41 7.0
Interleukin-16 6.9
CT-1 6.9
adenyl cyclase 6.9
Eosinophil peroxidase 6.9
adenosine A1 receptor 6.8
CYP2E 6.8
adenosine A2 receptor 6.6
MICE 6.6
eosinophil-derived neurotoxin 6.6
hypoxanthine guanine phosphoribosyltransferase 6.6
uridine kinase 6.5
XMP 6.5
BDP 6.5
PEF 6.5
IgG Fc receptor 6.4
EPP 6.4
histidase 6.4
AMP 6.3
ATP pyrophosphate-lyase 6.3
PI kinase 6.3
TNF-alpha stimulated 6.3
CYP2A 6.2
5' nucleotidase 6.2
RHC 6.1
ubiquitin C-terminal hydrolase 6.1
LAMA 6.1
Guanylate cyclase 6.1
adenosine deaminase 6.1
mitogen-activated protein kinase kinase 1 6.0
Interferon beta 6.0
AMPS 6.0
Phosphodiesterase 6.0
A-3 6.0
microsomal monooxygenase 6.0
TXNIP 6.0
CPX 5.9
SPT 5.9
tyrosinase-related protein 1 5.9
Adenylyl cyclase 5.9
ACH 5.9
arylsulfatase B 5.8
2',5'-oligoadenylate synthetase 5.8
PDE 5.7
IDP 5.7
ASF/SF2 5.7
CPA 5.7
CYP2C 5.7
CYP2D 5.7
ECI 5.7
ATP receptor 5.7
USP6 5.6
ABCE1 5.6
REA 5.6
growth hormone releasing hormone 5.6
more...
Disease
Acute bronchospasm 12.9
Periarteritis 11.9
cigarette abuse 10.5
infantile apnea 10.2
Uterine atrophy 10.2
Recurrent apnea 9.8
Clonic seizures 9.4
multifocal atrial tachycardia 8.8
Acute encephalopathy 8.6
Extrahepatic cholestasis 8.5
bacterial dysentery 8.2
status asthmaticus 7.9
Reye 7.5
Fulminant hepatitis 7.5
obstructive airway disease 7.3
exophoria 7.0
asthmatic bronchitis 6.9
vaginosis 6.7
bronchospasm 6.6
fibrocystic breast disease 6.2
vitamin B6 deficiency 6.1
CPX 5.9
heroin abuse 5.8
chronic obstructive pulmonary disease 5.8
intestinal tuberculosis 5.7
asthma 5.7
HPC 5.6
acute bronchiolitis 5.6
Stuttering 5.6
PDE 5.6
sympathomimetic 5.6
amnesic syndrome 5.6
childhood asthma 5.5
COPD exacerbation 5.5
chronic bronchitis 5.4
SRS 5.3
sick sinus syndrome 5.3
Nelson 5.3
speech disorder 5.2
Atopic 5.2
Reye's syndrome 5.2
prematurity 5.1
testicular atrophy 5.1
tracheobronchitis 5.1
COPD 5.1
FPP 5.1
respiratory acidosis 5.0
Diaphragm 4.9
acute pulmonary edema 4.9
TEC 4.9
upper respiratory infection 4.8
lipomatosis 4.8
phosphaturia 4.8
Luminal 4.7
erythrocytosis 4.7
tension pneumothorax 4.6
achondroplasia 4.5
ADCC 4.4
multi-infarct dementia 4.4
allergic conjunctivitis 4.4
cor pulmonale 4.4
Hepatotoxicity 4.4
bronchitis 4.3
multiple disorders 4.3
erythropoietic protoporphyria 4.2
bronchitis 4.2
chronic atrial fibrillation 4.2
Merkel cell carcinoma 4.1
MEC 4.1
hyaline membrane disease 4.1
sleep apnea 4.0
status epilepticus 3.9
TAS 3.9
chronic renal insufficiency 3.9
respiratory disease 3.8
vitreous humor 3.8
ICH 3.8
acute renal failure 3.8
alkalosis 3.8
left ventricular failure 3.8
more...
Symptom
Acquired stuttering 10.6
Periodic breathing 8.5
cardialgia 8.2
localized edema 8.2
inanition 6.1
CSR 6.1
chest tightness 5.4
incoordination 5.2
wheezing 4.9
Anoxia 4.8
pleuritic chest pain 4.7
renal colic 4.3
neurological disability 4.1
hypercapnia 4.0
tremor 3.9
decreased appetite 3.8
tachypnea 3.6
dyspnea 3.4
agitation 3.4
physical appearance 3.4
nausea and vomiting 3.3
seizures 3.2
exertional dyspnea 3.2
hyperoxia 3.2
nausea 3.0
cough 3.0
hemiplegia 3.0
chronic cough 3.0
twitching 2.9
blurred vision 2.9
tense 2.9
dizziness 2.7
spasm 2.7
shortness of breath 2.6
asthenia 2.6
vomiting 2.6
sore throat 2.5
polyuria 2.4
hypothermia 2.2
sleepiness 1.9
syncope 1.8
fatigue 1.7
diarrhea 1.7
respiratory distress 1.7
headache 1.6
insomnia 1.6
ENT 1.6
discomfort 1.5
lethargy 1.5
discomfort 1.4
flushing 1.3
myalgia 1.3
collapse 1.1
Welt 1.0
regurgitation 0.9
chest pain 0.9
analgesia 0.7
weakness 0.7
Ill 0.5
thinning 0.5
erythema 0.3
overweight 0.3
functional recovery 0.2
exhaustion 0.2
anesthesia 0.2
acidity 0.1
ataxia -0.0
angina -0.4
starvation -0.7
pain -1.7
Drug
Truphylline 13.9
Theophylline 13.9
Enprofylline 11.6
Oxtriphylline 11.4
Myvacet 10.8
Doxofylline 10.6
Riopan 10.6
Deseril 10.0
Vivalan 9.9
Xanthium 9.6
Mexitil 9.6
Fentanyl citrate 9.5
Dirithromycin 9.5
Valproic Acid 9.0
Ethmozine 8.9
Atrovent 8.9
Ethmozine 8.9
Ipratropium bromide 8.6
Cilomilast 8.6
Iotrolan 8.5
Explotab 8.5
Berotec 8.3
Rokitamycin 8.2
Methyldopa 8.2
Salbutamol 7.9
Ac-Di-Sol 7.9
Papaverine 7.9
Ethylenediamine 7.8
Bricanyl 7.6
Propentofylline 7.6
Beta-2 7.6
Midodrine 7.4
Castor oil 7.4
Kollidon 7.4
Rolipram 7.2
Dantrolene sodium 7.1
Salicylate 7.1
Gemifloxacin 7.1
Trapidil 7.1
Fenoterol 7.0
dibasic calcium phosphate 7.0
Roflumilast 6.9
Roflumilast 6.9
caffeine 6.7
Interferon beta 6.7
Zileuton 6.7
Trental 6.7
NLF 6.7
Cimetidine 6.6
GVG 6.6
Avicel PH 6.6
Cimetidine 6.6
Guar gum 6.4
Nedocromil sodium 6.4
Idarubicin 6.2
Ouabain 6.2
Talc 6.2
Adenosine triphosphate 6.1
Adenosine deaminase 6.1
Ammonium chloride 6.1
Thioridazine 6.0
Magnesium sulfate 5.9
Pyridoxal 5.9
Budesonide 5.6
Auranofin 5.6
Enrofloxacin 5.5
Atropine 5.4
Prednisolone 5.4
SPP 5.4
Zonisamide 5.4
Cilostazol 5.3
-deoxyadenosine 5.2
Bumetanide 5.2
Vitamin B 5.2
Atenolol 5.2
Trifluoperazine 5.2
Amiloride 5.0
Citric acid 4.9
Papain 4.8
9-THC 4.8
more...
Enzyme
arachidonoyl-CoA synthetase 9.5
PAF acetyltransferase 8.6
PdxH 8.2
pyridoxal kinase 7.8
PAF acetyltransferase 7.7
phosphodiesterase 7.3
PDE 7.1
lactose synthetase 6.4
uridine kinase 6.2
histidase 6.1
adenosine deaminase 6.1
adenosine deaminase 6.1
SPT 5.9
adenosine kinase 5.7
glycerophosphate acyltransferase 5.6
cGMP phosphodiesterase 5.6
adenylate cyclase 5.5
nucleotide pyrophosphatase 5.4
dextranase 5.3
SPT 5.1
isopeptidase 4.8
phosphatidylinositol 4-kinase 4.5
MAT 4.4
SST 4.4
5'-nucleotidase 4.3
PST 4.2
MAT 4.2
BIS 4.0
nucleotidase 3.9
uricase 3.7
arylsulfatase 3.7
tissue kallikrein 3.6
tyrosine aminotransferase 3.6
chymase 3.6
demethylase 3.5
purine nucleoside phosphorylase 3.5
aequorin 3.4
PAH 3.4
Mg2+-ATPase 3.4
aryl hydrocarbon hydroxylase 3.3
guanylate cyclase 3.2
prostaglandin synthetase 3.1
phosphorylase 3.1
botulinum neurotoxin 3.0
BAL 3.0
renin 2.9
hormone-sensitive lipase 2.9
chondroitinase 2.9
ADH 2.8
tyrosinase 2.8
CPT 2.8
sucrase 2.7
MIP 2.7
diamine oxidase 2.7
PKG 2.6
asparaginase 2.5
histone acetyltransferase 2.5
phosphoinositide 3-kinase 2.4
kallikrein 2.4
collagenase 2.4
CYP3A4 2.3
CPT 2.3
sulfatase 2.3
isocitrate dehydrogenase 2.2
CPT 2.2
hexosaminidase 2.1
phospholipase D 2.1
beta-glucuronidase 2.0
phosphofructokinase 2.0
protein kinase 2.0
phosphoenolpyruvate carboxykinase 1.9
MMP 1.9
lipoxygenase 1.9
phospholipase A2 1.7
invertase 1.7
deaminase 1.6
alpha-amylase 1.6
NO synthase 1.6
alkaline phosphatase 1.4
MEK 1.4
more...
Compound
Theophylline 13.5
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 12.4
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 12.4
Etamiphylline 11.9
2,3,5-trimethylphenol 11.6
Allocryptopine 11.4
1-Methylxanthine 11.4
Allocryptopine 11.4
Alloxazine 10.5
Alloxazine 10.5
Theobromine 10.4
Cinchonidine 9.9
Proxyphylline 9.9
Aminophylline 9.8
Paraxanthine 9.6
SQ 20009 9.5
Pheniramine 9.5
Normorphine 9.4
2-Chloroadenosine 9.3
2-Chloroadenosine 9.3
Nedocromil 9.0
DMU 8.9
DMU 8.9
Dibutyryl cyclic AMP 8.8
Dibutyryl cyclic AMP 8.8
Methylxanthine 8.6
Azelastine 8.6
DMU 8.6
Lumicolchicine 8.4
Dipyridamole 8.3
Dipyridamole 8.3
Dipyridamole 8.3
Dipyridamole 8.3
Hispidulin 8.3
Sulfisoxazole 8.3
cyclohexanone oxime 8.2
Moricizine 8.2
Relaxant 8.1
Olopatadine 8.1
2-imidazolidinone 8.1
docosanoic acid 8.0
Disodium cromoglycate 8.0
4-Methylumbelliferone 7.9
Salbutamol 7.9
Mannoheptulose 7.9
Papaverine 7.9
Metaproterenol 7.9
Midodrine 7.8
Xanthine 7.8
Fluticasone 7.7
Troleandomycin 7.7
Adenosine 7.7
Zafirlukast 7.7
Terbutaline 7.6
XTP 7.6
Cromolyn 7.6
Fluticasone 7.5
Enoxacin 7.5
2,3-dinor-thromboxane 7.4
Dantrolene sodium 7.4
MTU 7.4
SCMC 7.3
Milrinone 7.3
Bretylium 7.3
HSM 7.2
Diatrizoate 7.2
Diatrizoate 7.2
Ethacrynic acid 7.2
Salmeterol 7.0
Dofetilide 6.9
Benzothiazole 6.8
Metiamide 6.8
C 10 6.8
Lansoprazole 6.8
C 10 6.8
Nitrofurantoin 6.8
Lomefloxacin 6.8
caffeine 6.7
Chlortetracycline 6.7
Mexiletine 6.7
more...