Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D06103 (Theophylline)
2,023 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
AMP 205
phosphodiesterase 181
Sep 128
adenosine receptor 86
insulin 63
ATP 57
adenylate cyclase 47
glucagon 31
Mol 24
CO2 24
microsomal 23
adenosine deaminase 22
cyclic nucleotide phosphodiesterase 22
ADP 21
cytochrome P-450 18
renin 17
cyclic AMP phosphodiesterase 16
Gen 16
PDE4 14
COPD 14
mast cell 14
IgE 13
albumin 12
cytochrome P450 12
adenosine A1 receptor 12
vasopressin 12
cytokine 12
somatostatin 11
interferon 11
CYP1A2 11
substance P 10
serum albumin 10
5-hydroxytryptamine 10
prolactin 9
GTP 9
calmodulin 9
PDE 8
Pol 8
alkaline phosphatase 8
erythropoietin 7
adenyl cyclase 7
Mal 7
polypeptide 7
histone deacetylase 7
ATPase 7
calcitonin 7
epididymal 7
IL-8 7
glycoprotein 7
IMP 7
calcium channel 7
ANOVA 7
secretin 7
granulocyte 7
cyclooxygenase 7
hemoglobin 7
cytochrome 6
collagenase 6
serum protein 6
NMR 6
alpha, beta 6
tumor necrosis factor 6
histone 6
REM 6
lipopolysaccharide 6
growth hormone 6
C18 6
adenylyl cyclase 6
Phosphodiesterase 5
GABA 5
GMP 5
NAD 5
CA1 5
RPMI 5
P450 5
PEF 5
olfactory 5
Bcl-2 5
IL-5 5
CYP3A 5
more...
Disease
asthma 275
chronic obstructive pulmonary disease 104
SEM 29
depression 24
cancer 21
fits 19
bronchospasm 18
prematurity 16
congestive heart failure 15
diabetes 15
tumor 15
cholera 15
COPD 14
chronic bronchitis 13
melanoma 12
acute renal failure 11
respiratory disease 10
ischemia 10
renal disease 10
renal failure 10
influenza 9
sympathomimetic 9
heart failure 9
lung disease 9
bronchitis 8
PDE 8
respiratory failure 8
status asthmaticus 8
sleep apnea 8
cold 8
emphysema 8
bronchitis 8
pneumonia 7
uterus 7
hypertension 7
status epilepticus 7
cirrhosis 7
eosinophilia 6
epilepsy 6
gastroesophageal reflux disease 6
obstructive airway disease 6
NAME 6
mole 5
hepatocellular carcinoma 5
stroke 5
childhood asthma 5
neuroblastoma 5
anaphylaxis 5
myocardial ischemia 5
Evans 5
liver disease 5
breast cancer 5
pertussis 5
obstructive sleep apnea 5
cystic fibrosis 5
Thorax 5
obesity 5
Nelson 5
epididymis 5
mole 5
lung cancer 5
MRS 4
SCH 4
encephalopathy 4
chronic renal failure 4
hyperglycemia 4
pulmonary hypertension 4
carcinoma 4
SRS 3
cor pulmonale 3
GSH 3
dehydration 3
sudden infant death syndrome 3
Luminal 3
Merkel cell carcinoma 3
aggression 3
sick sinus syndrome 3
peptic ulcer 3
malnutrition 3
bronchopulmonary dysplasia 3
more...
Symptom
seizures 48
dyspnea 19
tremor 18
cough 12
nausea 12
vomiting 12
diarrhea 12
fatigue 11
headache 11
wheezing 9
agitation 8
hypercapnia 8
anesthesia 8
nausea and vomiting 6
pain 5
hypothermia 5
collapse 4
discomfort 4
incoordination 4
respiratory distress 4
discomfort 4
dizziness 4
weakness 4
CSR 3
hyperoxia 3
spasm 3
sleepiness 3
analgesia 3
insomnia 2
chest pain 2
shortness of breath 2
exertional dyspnea 2
Welt 2
tachypnea 2
chest tightness 2
syncope 2
Periodic breathing 2
localized edema 2
hemiplegia 2
overweight 2
Ill 1
physical appearance 1
flushing 1
functional recovery 1
inanition 1
myalgia 1
decreased appetite 1
asthenia 1
neurological disability 1
exhaustion 1
renal colic 1
twitching 1
pleuritic chest pain 1
thinning 1
ataxia 1
acidity 1
cardialgia 1
sore throat 1
polyuria 1
starvation 1
chronic cough 1
blurred vision 1
erythema 1
Acquired stuttering 1
lethargy 1
ENT 1
regurgitation 1
angina 1
Anoxia 1
tense 1
Drug
Theophylline 2023
caffeine 147
Xanthium 41
Monit 33
Asthma 28
Salbutamol 16
Enprofylline 15
lactose 13
Nephron 13
Ouabain 12
Cimetidine 10
Cimetidine 10
Atropine 9
citric acid 8
Indomethacin 8
Papaverine 7
Cardiovasc 6
Salicylate 5
CTX 5
-deoxyadenosine 5
Histamine 5
Ipratropium bromide 5
CSF 5
Dermatol 5
lysine 5
Glucagon 4
nitroglycerin 4
Prednisolone 4
Rolipram 4
Ethanol 4
Adenosine triphosphate 4
Valproic Acid 3
Gel 3
ICI 3
9-THC 3
Clonidine 3
Adenosine deaminase 3
Amiloride 3
Atrovent 3
Methyldopa 3
Doxofylline 3
Vitamin B 3
Ethylenediamine 3
ampicillin 3
Amiloride 3
Ranitidine 2
Budesonide 2
Forskolin 2
Dial 2
Fenoterol 2
Methylene blue 2
Ringer's solution 2
IL-2 2
CaCl2 2
IFN-gamma 2
MAP 2
Kollidon 2
CaCl2 2
Beta-2 2
Atenolol 2
Riopan 2
Dirithromycin 2
CaCl2 2
Phentolamine 2
NAG 2
Angiotensin II 2
NADH 1
Asn 1
Glide 1
Lactose 1
Roflumilast 1
Kainic acid 1
Gemifloxacin 1
Growth hormone 1
Ethmozine 1
ABC 1
Zileuton 1
Allergen 1
Adriamycin 1
pyridoxal phosphate 1
more...
Enzyme
phosphodiesterase 182
adenylate cyclase 54
PDE 32
adenosine deaminase 22
adenosine deaminase 22
protein kinase 20
renin 17
alkaline phosphatase 8
peroxidase 8
ATPase 7
collagenase 6
mitogen-activated protein kinase 6
guanylate cyclase 5
protein kinase C 5
5'-nucleotidase 4
tyrosinase 4
demethylase 4
ERK 4
adenosine kinase 3
phospholipase C 3
MEK 3
thrombin 3
NO synthase 3
phospholipase A2 3
cGMP phosphodiesterase 3
pyridoxal kinase 3
catalase 3
superoxide dismutase 3
phosphorylase 3
PAH 3
MAT 2
SPT 2
beta-glucuronidase 2
AMPK 2
kallikrein 2
CPT 2
MAT 2
CYP3A4 2
calcineurin 2
trypsin 2
lipoxygenase 2
SPT 2
phosphoinositide 3-kinase 2
glutathione peroxidase 2
MIP 2
ACE 2
lipase 1
deaminase 1
SST 1
prostaglandin synthetase 1
PAF acetyltransferase 1
purine nucleoside phosphorylase 1
MMP 1
PKG 1
phosphofructokinase 1
ornithine decarboxylase 1
histidase 1
nucleotidase 1
PAF acetyltransferase 1
focal adhesion kinase 1
aequorin 1
glutathione reductase 1
monoamine oxidase 1
proteasome 1
sucrase 1
carbonic anhydrase 1
aspartate aminotransferase 1
hexosaminidase 1
phospholipase D 1
nucleotide pyrophosphatase 1
uridine kinase 1
isocitrate dehydrogenase 1
CPT 1
PST 1
tissue kallikrein 1
Mg2+-ATPase 1
elastase 1
lysozyme 1
gamma-glutamyl transpeptidase 1
uricase 1
more...
Compound
Theophylline 2022
Clin 284
AMP 215
cAMP 157
calcium 151
caffeine 147
sodium 146
Dec 124
water 102
glucose 97
Adenosine 89
oxygen 67
ATP 57
cGMP 55
phosphate 49
noradrenaline 46
potassium 43
DNA 34
Aminophylline 30
CO2 29
ADP 28
adenylate 26
Isoproterenol 26
prostaglandin E1 25
acetate 25
Dipyridamole 23
Dipyridamole 23
Dipyridamole 23
Dipyridamole 23
arginine 22
ADP 22
galactose 22
ADP 21
Adrenal 20
ethanol 19
creatinine 18
HCl 18
PEG 17
Insulin 17
Salbutamol 16
glycerol 16
nitric oxide 16
carbonate 15
PGE2 15
leucine 14
bromide 14
Propranolol 14
Propranolol 14
urea 13
salt 13
sodium chloride 13
Ouabain 12
Norepinephrine 12
Dibutyryl cyclic AMP 12
Dibutyryl cyclic AMP 12
Diabetol 11
acetic acid 11
Abbott 11
hydrogen 11
Cardiol 11
methanol 11
Mg2+ 10
PEG 10
Verapamil 10
GTP 10
prostacyclin 9
Atropine 9
salicylic acid 9
acetonitrile 9
Theobromine 9
tyrosine 8
Indomethacin 8
5-HT 8
GMP 8
Optimal 8
Verapamil 8
ammonium 8
IMP 7
TSH 7
ethyl acetate 7
more...