Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D05575 (Pramipexole)
 205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
PTPRD protein 16.2
Meis homeobox 1 14.4
D3nf 11.7
SLC18A2 11.5
KNS 11.5
PPX 11.2
hOCT2 11.2
D3R 11.1
CTSL 11.0
Monoamine oxidase B 10.8
organic cation transporter 2 10.7
dopamine D3 receptor 10.6
PTPRD 10.5
MATE2-K 10.4
VMAT2 10.3
PLM 9.4
dopamine D2 receptor 9.3
CGI 9.3
organic cation transporter 1 9.3
OBX 9.1
Nurr1 8.9
D2R 8.9
OCT2 8.6
GDS 8.5
CHP 8.5
microtubule associated protein 8.5
TIS) 8.5
OCT1 8.4
DA1 8.4
DAT 8.3
organic cation transporter 8.2
OCT3 8.1
MES 7.9
dopamine D1 receptor 7.9
D2 dopamine receptor 7.9
DARPP-32 7.8
Cholinesterase 7.8
SWS 7.5
MPP 7.5
LRRK2 7.4
vesicular monoamine transporter 2 7.3
SCH 7.2
dopa decarboxylase 7.2
SMD 7.2
DCX 7.2
TAK 7.1
neurotrophic factor 7.0
DJ-1 6.9
superoxide dismutase 1 6.9
PINK1 6.9
PGI 6.9
tyrosine hydroxylase 6.8
dopamine transporter 6.7
CIS 6.7
MAP2 6.6
aconitase 6.6
soluble guanylyl cyclase 6.4
proteasome inhibitor 6.0
glial cell line-derived neurotrophic factor 6.0
p38 MAP kinase 6.0
Bak 5.9
E14 5.9
synuclein 5.8
REM 5.8
thyroid stimulating hormone 5.8
dream 5.8
huntingtin 5.6
ALS 5.5
Prolactin 5.5
membrane glycoprotein 5.4
ECD 5.4
SAS 5.4
serotonin transporter 5.4
HO-1 5.3
protein tyrosine phosphatase 5.3
HEK 5.3
alpha-synuclein 5.2
adrenocorticotropic hormone 5.1
GMP 5.1
poly(ADP-ribose) polymerase 5.0
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Disease
Motor Skills Disorders 16.2
Mild depression 12.8
KNS 12.0
restless legs syndrome 11.2
Cotard's syndrome 10.7
pathological gambling 10.1
hypersexuality 9.6
OBX 9.6
bipolar depression 9.2
parasomnia 8.8
Essential tremor 8.6
unipolar depression 8.6
SWS 8.5
REM sleep behavior disorder 8.4
Parkinson's disease 8.1
major depressive episode 8.1
akinesia 8.1
compulsion 8.1
abnormal involuntary movements 7.9
melancholia 7.7
cocaine abuse 7.7
dyskinesia 7.7
hypomania 7.6
antidiuresis 7.5
anhedonia 7.5
trichotillomania 7.3
behavior disorder 7.3
SCH 7.3
SMD 7.2
hallucinations 7.2
perseveration 7.1
ICH 7.1
bruxism 7.1
catalepsy 7.0
movement disorder 6.7
mania 6.6
Dementia with Lewy bodies 6.6
SWS 6.5
delusions 6.2
parkinsonism 6.2
schizoaffective disorder 6.2
MRT 6.0
tardive dyskinesia 5.9
radiculopathy 5.9
HAM 5.8
tic 5.6
drug addiction 5.6
progressive supranuclear palsy 5.5
major depressive disorder 5.4
agranulocytosis 5.3
photosensitivity 5.2
disinhibition 5.1
fibromyalgia 5.1
lymphedema 5.0
psychosis 5.0
eating disorder 5.0
sleep disturbances 4.8
affective disorder 4.8
carcinoma in situ 4.7
renal impairment 4.7
amyotrophic lateral sclerosis 4.6
PDB 4.5
depression 4.5
neuroblastoma 4.5
macular degeneration 4.4
SAR 4.4
sleep apnea 4.3
incontinence 4.2
ADHD 4.1
neurological disease 4.1
addiction 4.1
chronic pain 4.0
varices 3.8
prolapse 3.7
subarachnoid hemorrhage 3.7
schizophrenia 3.7
tetanus 3.6
rare disease 3.6
NAME 3.5
incontinence 3.5
more...
Symptom
Other hallucinations 17.2
motor symptom 9.4
Psychiatric symptoms 8.9
leg edema 7.8
consciousness disturbance 7.6
dysesthesia 7.4
orofacial pain 7.3
eds 7.2
sleepiness 7.2
muscle rigidity 7.2
insomnia 6.9
tremor 6.2
bradykinesia 6.0
shoulder pain 5.8
dystonia 5.8
nausea 5.5
apathy 5.2
dizziness 5.0
paresthesia 5.0
constipation 4.9
hypotonia 4.7
agitation 4.7
hypothermia 4.2
fatigue 3.2
discomfort 2.8
discomfort 2.7
vomiting 2.3
pain 1.2
anesthesia 0.5
Drug
Pramipexole 17.2
Pramipexole 17.2
Etilevodopa 16.2
Mirapex 15.8
Frentizole 14.2
Akineton 13.2
Rotigotine 12.6
Tapentadol 10.4
Lisuride 10.2
Rasagiline 10.0
Carbidopa 9.9
Prozac 9.3
Sulpiride 9.0
Modafinil 8.7
Pregabalin 8.5
Sinemet 8.2
DEX 7.4
TAK 7.3
Azithromycin 7.0
Cimetidine 6.6
Cimetidine 6.5
Spectrum 5.3
Portal 5.2
MAP 3.3
ROS 3.0
Enzyme
DAT 8.3
MPP 7.4
DOPA decarboxylase 7.2
tyrosine hydroxylase 6.9
aconitase 6.5
AMPK 4.6
MAP 4.4
complex I 4.1
monoamine oxidase 3.9
glutathione peroxidase 3.8
AMPK 3.6
AMP-activated protein kinase 3.6
PARP 3.5
proteasome 3.4
lactate dehydrogenase 3.4
caspase-3 3.1
phosphodiesterase 3.0
creatine kinase 3.0
superoxide dismutase 3.0
catalase 2.5
luciferase 2.0
ACS 1.0
protein kinase 0.9
mitogen-activated protein kinase 0.7
Compound
C10H17N3S 17.2
C10H17N3S 17.2
PD 168 14.3
4-pyrimidinol 14.2
Ropinirole 13.1
Pergolide 11.0
1-Methyl-4-phenylpyridinium 10.8
Entacapone 10.6
Tolcapone 10.5
Harmaline 10.1
Benzothiazole 10.1
Cabergoline 9.3
4-phenyl-1,2,3,6-tetrahydropyridine 9.3
Ergot 9.2
Rhein 9.2
Selegiline 9.1
Spiperone 9.0
DLT 8.7
Riluzole 8.6
Venlafaxine 8.4
Citalopram 8.4
Hydroxychloroquine 8.3
Sertraline 8.3
DAT 8.3
Amantadine 8.3
Amantadine 8.3
Paroxetine 8.3
DHBA 8.3
Amantadine 8.2
Bromocriptine 8.2
DHBA 8.1
MES 7.9
MES 7.9
Amantadine 7.9
Thioflavin T 7.8
L-DOPA 7.8
Tunicamycin 7.8
Dopamine 7.6
MPP 7.5
MPTP 7.5
MPP 7.4
Azithromycin 7.4
Risperidone 7.0
MK801 6.9
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6.6
Clozapine 6.5
Methamphetamine 6.5
HVA 6.5
Dopa 6.5
DOPAC 6.4
Chloroquine 6.4
Chloroquine 6.4
Haloperidol 6.2
Haloperidol 6.0
PDB 5.4
dUTP 5.3
TPA 5.0
TPA 4.8
Adenosine 4.5
benzoic acid 4.3
TCA 4.1
GMP 4.1
Nicotine 4.1
MAP 4.0
palmitic acid 4.0
H2O2 3.9
Neuronal 3.8
DSM 3.6
Triton X-100 3.4
hexane 3.3
5-HT 3.3
MTT 3.3
fluorine 3.2
cGMP 2.9
salt 2.4
nitric oxide 2.2
noradrenaline 2.2
benzene 2.2
glutamate 2.1
sodium 2.0
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