Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: KEGG:D05575 (
Pramipexole
)
205
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
tyrosine hydroxylase
11
dopamine D2 receptor
10
Sep
10
SCH
5
CGI
5
Mol
5
prolactin
5
D3R
5
dopamine D3 receptor
5
neurotrophic factor
4
Bcl-2
4
dopamine transporter
3
hOCT2
3
DAT
3
Pol
3
olfactory
3
VMAT2
3
growth hormone
2
HEK
2
lactate dehydrogenase
2
more...
Disease
Parkinson's disease
113
restless legs syndrome
28
depression
25
pathological gambling
8
dyskinesia
7
parkinsonism
7
hallucinations
7
major depressive disorder
6
psychosis
6
schizophrenia
5
SCH
5
bipolar depression
4
akinesia
4
neuroblastoma
4
addiction
3
unipolar depression
3
amyotrophic lateral sclerosis
3
mania
3
movement disorder
3
delusions
3
more...
Symptom
sleepiness
12
tremor
9
insomnia
8
nausea
7
pain
4
fatigue
3
dystonia
3
constipation
2
agitation
2
hypothermia
2
motor symptom
2
dizziness
2
shoulder pain
1
discomfort
1
hypotonia
1
anesthesia
1
dysesthesia
1
vomiting
1
muscle rigidity
1
apathy
1
more...
Drug
Pramipexole
205
Pramipexole
204
Rotigotine
4
Mirapex
4
Sulpiride
2
Spectrum
2
Prozac
1
ROS
1
Pregabalin
1
DEX
1
Lisuride
1
Carbidopa
1
Portal
1
Modafinil
1
MAP
1
Azithromycin
1
Rasagiline
1
Frentizole
1
Akineton
1
TAK
1
more...
Enzyme
tyrosine hydroxylase
11
DAT
3
superoxide dismutase
3
lactate dehydrogenase
2
proteasome
2
MPP
2
caspase-3
2
glutathione peroxidase
2
catalase
2
protein kinase
1
AMP-activated protein kinase
1
AMPK
1
ACS
1
monoamine oxidase
1
mitogen-activated protein kinase
1
AMPK
1
DOPA decarboxylase
1
complex I
1
phosphodiesterase
1
aconitase
1
more...
Compound
Clin
16
Dec
15
L-DOPA
13
Dopamine
11
oxygen
9
water
8
sodium
7
MPTP
6
Ropinirole
6
hydrogen
5
salt
4
H2O2
3
nitric oxide
3
DAT
3
calcium
3
MES
2
tyrosine
2
MES
2
Pergolide
2
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
2
more...