Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D04996 (Methylcellulose)
 116 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The buffer uptake and mass loss characteristics of freeze dried unitary devices prepared from aqueous solutions of Sodium Carboxymethylcellulose (CMC), cross-linked Sodium Alginate (ALG) and Methylcellulose (MC) were evaluated. Some of the devices also contained 50% (by weight) Poly (d,l Lactide-co-Glycolide) (PLGA) microspheres. Devices prepared from cross-linked ALG solutions imbibed the highest amounts of isotonic Phosphate Buffered Saline, followed by those from prepared from CMC solutions, and lastly, MC. In all cases, the presence of microspheres within the devices significantly decreased buffer uptake. Uptake was determined to be approximately proportional to the weight percent of the hydrophilic matrix polymer. Highest levels of overall mass loss were observed with devices prepared from cross-linked ALG solutions (approximately 80% in 60 days), followed by those prepared from CMC solutions (approximately 45 to 65%) and MC (approximately 35 to 60%). A majority of the unitary devices retained their shape and integrity, however, over the two month test period, indicating possible use as long term delivery systems for incorporated bone growth factors.
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PMID:Buffer uptake and mass loss characteristics of freeze-dried cellulosic and alginate devices. 897 15

Ultrasonic biomicroscopy (UBM) has added greatly to our understanding of the development of certain forms of glaucoma. Methylcellulose is usually recommended as the appropriate coupling medium between the transducer and the eye because of its increased viscosity, which makes it more easily retained on the eye. A new water bath has been developed that fits the eye so well that saline, a superior coupling agent, can be substituted for methylcellulose. This new water bath is a flexible polysiloxane cup with a beveled inner edge, providing a watertight seal and thus permitting the use of saline as the coupling medium for UBM. Saline, because of its lack of impurities, generates images that are superior in quality to those produced with methylcellulose as the coupling medium.
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PMID:A new water bath for ultrasonic biomicroscopy. 924 66