Gene/Protein
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Drug
Enzyme
Compound
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Target Concepts:
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Query: KEGG:D04582 (
Iopentol
)
25
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To compare the fibrillatory propensity of low concentrations of contrast media (140 mg I/ml) the ionic, ratio 1.5, contrast medium meglumine diatrizoate, the non-ionic, ratio 3, medium iopentol and equimolar glucose (0.37 mol/l) were perfused into 35 isolated rabbit hearts. The three substances were compared at three levels of sodium concentration (0.77 and 154 mmol Na+/l). Meglumine diatrizoate without sodium caused the highest frequency of
ventricular fibrillation
(91%).
Iopentol
without sodium caused a significantly lower frequency of
ventricular fibrillation
(17%). Glucose without sodium caused no fibrillation. The addition of 77 or 154 mmol Na+/l significantly decreased the frequency of
ventricular fibrillation
of both meglumine diatrizoate (3% and 6%) and iopentol (0%). Meglumine diatrizoate with sodium added caused a lower frequency of
ventricular fibrillation
than iopentol without sodium. At equal sodium concentrations (0.77 and 154 mmol Na+/l) glucose caused smaller reduction in contractile force and heart rate than iopentol, and iopentol caused smaller reduction in contractile force and heart rate than diatrizoate. It is concluded that addition of sodium to ionic or non-ionic contrast media without sodium decreases the risk of
ventricular fibrillation
.
...
PMID:Reducing the risk of ventricular fibrillation by adding sodium to ionic and non-ionic contrast media with low iodine concentration. Coronary perfusion of the isolated rabbit heart with meglumine diatrizoate or iopentol at 140 mg I/ml and 0-154 mmol Na+/l. 264 14
In twenty beagle dogs selective injections were made into the left coronary artery with iopentol, iohexol and metrizoate in doses of 4 ml, 8 ml and 16 ml. Thirty-six iopentol injections, 35 iohexol injections and 37 metrizoate injections were made. Frequencies of
ventricular fibrillation
were significantly lower (p less than 0.05) after iopentol (0%) and iohexol (3%) than after metrizoate (22%).
Iopentol
and iohexol also produced significantly less decrease in aortic blood pressure than metrizoate at the different doses.
...
PMID:Selective injection of iopentol, iohexol and metrizoate into the left coronary artery of the dog. Induction of ventricular fibrillation and decrease of aortic pressure. 298 Mar 15
