Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: KEGG:D04412 (
Lugol
)
396
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Objective:
To discuss the feasibility and clinical application value of the laryngeal iodine staining under the electronic fiber laryngoscope.
Method:
Will meet the inclusion criteria of 90 patients, randomly divided into three groups, set to a, b, c group.a ,all patients in the a group were examined by electronic fiber mirror, NBI mode and 0.5%
Lugol
liquid iodine staining method in three ways. b, all patients in the b group were examined by electronic fiber mirror, NBI mode and 1.0%
Lugol
liquid iodine staining method in three ways. c,all patients in the c group were examined by electronic fiber mirror, NBI mode and 1.5%
Lugol
liquid iodine staining method in three ways. The location and range of positive lesions were recorded in each person of the three groups, positive lesions were biopsy, if the positive lesion is repeated, the site can only take a biopsy. As a diagnostic gold standard, the results of the other tests were compared with the results of other tests. And to observe the color of iodine in the throat, all patients were followed up for 24 hours in the presence of dyspnea, severe pain in the throat and other symptoms, and 24 hours after the examination again electronic fiber optic examination. Biopsy was performed in all patients, as gold standard. Using chi square test, inspection standard
P
<0.05.
Result:
As the solution of the iodine concentration increased, the rate of the laryngeal was cancer gradually increased. Ninety people take part in the experiment, no one has serious complications. All the patients have no significant inflammation on the mucous membrane of the throat and the subglottic airway afer 24 hours, by the electronic fiber laryngoscope. 1% and the following concentration of
Lugol
solution for iodine staining, sensitivity to the diagnosis of early
laryngeal cancer
was higher than that of electronic fiber,the two methods were compared, and the statistical analysis was performed(
P
>0.05). No statistical significance. There was no significant difference in the diagnosis of early
laryngeal cancer
. Contrast between iodine stain with 1.5%
Lugol
solution and electronic fiber sus pension, after statistical calculation(
P
<0.05);both are statistically significant, and the difference is significant.Comparison of iodine stain with 1.5%
Lugol
solution and NBI examination, make statistical analysis,
P
>0.05, there was no significant difference between the both.
Conclusion:
The 1.5% and below the concentration of the iodine staining under the electronic fiber laryngoscope can be safely applied to inspect the throat, and 1.5%
Lugol
iodine solution in the diagnosis of
laryngeal cancer
in the early stage of
laryngeal cancer
is better than using electronic, and has a certain value in clinical application.
...
PMID:[Clinical application of iodine solution staining in the diagnosis of early laryngeal cancer with electronic endoscope]. 2979 32
