Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D03684 (Denosumab)
 549 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
RANKL 146
RANK 119
osteoprotegerin 34
Sep 29
BMD 29
cytokine 25
parathyroid hormone 24
sclerostin 17
aromatase 16
estrogen receptor 15
tumor necrosis factor 15
OPG 15
receptor activator of NF-kappaB ligand 14
AMG 14
insulin 14
cathepsin K 11
PTH 10
type I collagen 10
She 10
TNF 10
more...
Disease
osteoporosis 274
cancer 112
bone metastases 91
prostate cancer 76
tumor 72
breast cancer 56
metastases 39
bone disease 37
Best 30
BMD 29
hypercalcemia 28
rheumatoid arthritis 24
multiple myeloma 23
spinal cord compression 18
Giant cell tumor 15
hyperparathyroidism 14
Giant cell tumor of bone 14
osteoporotic fracture 13
renal impairment 10
osteosarcoma 10
more...
Symptom
pain 56
bone pain 13
back pain 5
menopausal symptoms 3
fatigue 3
shoulder pain 2
weakness 2
Wind 1
tremor 1
analgesia 1
syncope 1
Ill 1
hot flashes 1
dizziness 1
cancer pain 1
muscle cramps 1
polyuria 1
leg pain 1
low back pain 1
functional recovery 1
more...
Drug
Denosumab 549
Zoledronic acid 26
Teriparatide 25
Zoledronic acid 22
Bevacizumab 21
Bortezomib 20
Everolimus 17
Sorafenib 17
Ezetimibe 16
Pegasys 15
Adalimumab 15
Sunitinib malate 15
Vorinostat 14
G-CSF 14
Dasatinib 14
Rosuvastatin calcium 14
Gleevec 13
Pregabalin 12
Cetuximab 12
Aliskiren fumarate 12
more...
Enzyme
cathepsin K 11
alkaline phosphatase 9
GSK 6
acid phosphatase 2
ACE 2
ADH 2
ERK 2
focal adhesion kinase 2
catalase 2
alcohol dehydrogenase 2
arginine deiminase 1
ATP synthase 1
trypsin 1
MCS 1
alanine aminotransferase 1
prostate-specific antigen 1
calcineurin 1
CGT 1
mitogen-activated protein kinase 1
plasmin 1
more...
Compound
Clin 93
calcium 83
Dec 45
vitamin D 33
BMD 29
sodium 19
strontium 16
acetate 15
salt 13
Paclitaxel 12
Aripiprazole 12
bromide 11
TNF 10
Temsirolimus 10
Rapamycin 9
5-Azacytidine 8
Androgen 7
potassium 7
Amlodipine 7
CTX 7
more...