Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D03434 (Cellulase)
 512 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Studies were conducted to evaluate the effects of cellulase from Trichoderma viride in a diet for broilers containing high levels of wheat bran. Broiler-type, mixed-sex chicks were fed from 3 to 8 weeks of age. Wheat bran was added at 0, 10, and 20% levels. A fourth group received the 20% wheat bran plus the cellulase enzyme added at the level of .008%. A portion of the chicks was used in a digestibility study with chromic oxide as an indicator. The summarized data showed that cellulose treatment had a significant effect on reducing feed consumption (P less than .01) and an apparent effect in improving feed-to-gain ratio. Cellulase supplementation significantly improved the digestibility of cell wall components (P less than .01). Calcium, phosphorus, iron, zinc, and copper associated with cell walls were solubilized by cellulase. Iron balance was negative in the groups without cellulase; however, iron, which is bound by the bran, apparently was made available for absorption by cellulase.
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PMID:Effects of cellulase from Trichoderma viride on nutrient utilization by broilers. 299 59

In Thermomonospora fusca YX, endocellulase synthesis varies over a 100-fold range depending on the carbon source used. This study shows that the variation is caused by two regulatory mechanisms: an induction mechanism that increases the rate of endocellulase synthesis about 20-fold and a growth rate-dependent repression mechanism that changes the rate of synthesis over a 6-fold range in both induced and noninduced cells. In T. fusca, endocellulase synthesis can be induced by cellulose, cellobiose, or cellodextrin. Cellulase is involved in inducer generation from cellulose. Growth rate-dependent repression can be reversed by limiting cultures for carbon, nitrogen, or, to a lesser extent, phosphorus. Further evidence for two separate regulatory mechanisms is provided by the isolation of mutants (CC-1 and CC-2) whose endocellulases are synthesized constitutively but are still sensitive to growth rate-dependent repression. These conclusions about total endocellulase synthesis were extended to the individual endocellulases by showing that three T. fusca endocellulases are coordinately regulated.
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PMID:Regulation of beta-1,4-Endoglucanase Synthesis in Thermomonospora fusca. 1634 65