Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D03348 (Lactase)
 283 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of maternal protein-energy malnutrition and exposure to nitrofen on selected aspects of intestinal morphology and function were studied in the fetal rat. Pregnant rats were fed, throughout gestation, diets containing 24% or 6% casein as the sole source of protein. Reduced total food intake produced protein-energy malnutrition (PEM). Each diet group was divided in half and gavaged with either 12.5 mg nitrofen in corn oil/kg/day or corn oil carrier only from days 7 to 21 of gestation. Body weight, intestinal weight, length, and diameter were measured as were villus length (VL), villus width (VW), and number of villi per length of intestine (VMM). Protein (horseradish peroxidase) and lipid absorption were studied histochemically. Lactase and dipeptidase activities were determined in proximal, medial, and distal thirds of the intestine. Results showed that the restricted maternal diet resulted in reduced fetal body weight (BW), intestinal weight (IW) and length (IL), reduced IW/BW and IW/IL ratios, VH, and VMM. The VW was reduced only in the distal third. Protein and lipid absorption were unaffected. Lactase and dipeptidase activities were reduced. Maternal nitrofen exposure resulted in reduced body weight, intestinal size, and lipid absorption, with some evidence of interaction with the diet effects on enzyme activities. It is concluded that effects of maternal malnutrition were extensive, but that nitrofen exposure, at this dosage level, is not likely to contribute to the postnatal fetal mortality rate in either adequately nourished or malnourished rats.
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PMID:Effects on the fetal rat intestine of maternal malnutrition and exposure to nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether). 287 36

Small intestinal dipeptidases (substrate: glycyl-L-leucine, L-methionyl-L-methionine, and L-alanyl-L-proline) were determined in uraemic and sham-operated rats given normal protein diet (24%), low protein diet (6%), and total parenteral nutrition for 10-14 days. Disaccharidases (substrate: maltose, sucrose, trehalose, and lactose) were measured after normal and low protein diet orally. Glycyl-L-leucine and L-methionyl-L-methionine splitting activities were increased on normal protein diet but decreased after low protein feeding in uraemic rats. Parenteral nutrition further lowered the enzyme activity. L-Alanyl-L-proline dipeptidase activity showed an inverse relation to protein intake with the highest values after parenteral nutrition. Lactase increased in uraemic rats after low protein feeding and was the only disaccharidase to be affected by the nutritional change. It is suggested that the changes of the intestinal dipeptidase activities in uraemia are adaptive to variation in the luminal content of di- and oligopeptides because of the type of nutrition given.
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PMID:Small intestinal dipeptidases and disaccharidases in uraemic rats on a low protein diet. 640 96