Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: KEGG:D03301 (
PDL
)
658
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
T cell infiltration of tumors plays an important role in determining colorectal cancer disease progression and has been incorporated into the Immunoscore prognostic tool. In this study, mass cytometry was used to demonstrate a significant increase in the frequency of both conventional CD25
+
FOXP3
+
CD127
lo
regulatory T cells (Tregs) as well as
BLIMP-1
+
Tregs in the tumor compared with nontumor bowel (NTB) of the same patients. Network cluster analyses using SCAFFoLD, VorteX, and CITRUS revealed that an increase in
BLIMP-1
+
Tregs was a single distinguishing feature of the tumor tissue compared with NTB.
BLIMP-1
+
Tregs represented the most significantly enriched T cell population in the tumor compared with NTB. The enrichment of ICOS, CD45RO, PD-1,
PDL
-1, LAG-3, CTLA-4, and TIM-3 on
BLIMP-1
+
Tregs suggests that
BLIMP-1
+
Tregs have a more activated phenotype than conventional Tregs and may play a role in antitumor immune responses.
...
PMID:High-Dimensional Mass Cytometric Analysis Reveals an Increase in Effector Regulatory T Cells as a Distinguishing Feature of Colorectal Tumors. 3072 10
