Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: KEGG:D02259 (
NaI
)
1,823
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We studied whether
eosinophil peroxidase
(
EPO
), an eosinophil granule basic protein, can alter beta-adrenergic receptor (BAR) density on the guinea pig lung membrane. Lung membrane was first preincubated with 1-10 U/ml
EPO
and then incubated with 10(-4) M
NaI
and 10(-4) or 10(-6) M H2O2 for 2 hours. BAR density was determined using (-)125I-cyanopindolol.
EPO
combined with 10(-4) M H2O2 and I decreased the BAR density in a concentration-dependent manner. When only 10(-4) M H2O2 was used, the decrease in BAR density was small but significant. When compared to I, bromide was less effective and chloride alone was not effective. These results suggest that
EPO
is one of the factors responsible for beta-adrenergic blockade in asthma.
...
PMID:Effect of eosinophil peroxidase on beta-adrenergic receptor density on guinea pig lung membrane. 133 76
