Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: KEGG:D02052 (
Barium sulfate
)
55
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Poly(methyl methacrylate) (PMMA) bone cements have been widely used in clinical practices. In order to enhance PMMA's imaging performance to facilitate surgical procedures, a supplementation of radiopaque agent is needed. However, PMMA bone cements are still facing problems of loosening and bacterial infection. In this study, a multifunctional coating to simultaneously encapsulate drug and prevent the infection of radiopaque agent has been developed.
Barium sulfate
(BaSO
4
), a common radiopaque agent, is used as a substrate material. We successfully fabricated porous BaSO
4
microparticles, then modified with hexakis-(6-iodo-6-deoxy)-alpha-cyclodextrin (I-CD) and
silver
(Ag) to obtain porous BaSO
4
@PDA/I-CD/Ag microparticles. The porous nature and presence of PDA coating and I-CD on the surface of microparticles result in efficient loading and release of drugs such as protein. Meanwhile, the radiopacity of BaSO
4
@PDA/I-CD/Ag microparticles is enhanced by this multifunctional coating containing Ba, I and Ag. PMMA bone cements containing BaSO
4
@PDA/I-CD/Ag microparticles show 99% antibacterial rate against both
Staphylococcus aureus
(
S. aureus
) and
Escherichia Coli
(
E. coli
), yet without apparently affecting its biocompatibility. Together, this multifunctional coating possessing enhanced radiopacity, controlled drug delivery capability and exceptional antibacterial performance, may be a new way to modify radiopaque agents for bone cements.
...
PMID:Multifunctional Coating to Simultaneously Encapsulate Drug and Prevent Infection of Radiopaque Agent. 3102 23
