Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: KEGG:D02027 (Tranilast)
 205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tranilast (N-5) as a mast-cell stabilizer is widely used in cases of bronchial asthma and nasal allergy. Some reports showed that N-5 is effective against keloids and ulcerative colitis. So, it is considered that N-5 inhibits cell-mediated immunity. N-5 inhibited BCG-CWS-stimulated lymphocyte proliferation which was proved to be mainly operated by OKT4 positive T cells. Production of the lymphokine from BCG-CWS-stimulated lymphocytes was suppressed by the addition of N-5. Thus, it is demonstrated that N-5 inhibits delayed type hypersensitivity in vitro.
 ...
PMID:[Effect of tranilast (N-5) on cellular immunity--delayed type hypersensitivity]. 171 10