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Query: KEGG:D02003 (
NBT
)
1,323
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cell dissociation and acquisition of cell motility are major events in morphogenesis, wound repair, and cancer invasion and metastasis. We have used the
NBT
-II bladder carcinoma cell line as a model system to study the mechanisms of these events. Upon exposure to acidic fibroblast growth factor (aFGF),
NBT
-II cells undergo morphological changes that resemble those described in epithelial-mesenchymal transitions, i.e., dissociation of some or all polygonal epithelial cells and their transformation into motile, fibroblastic-like cells. The disruption of intercellular contacts, which accompanies cell dissociation and acquisition of motility, is correlated with a redistribution of
E-cadherin
, a Ca(2+)-dependent cell adhesion molecule, over the entire cell surface and within the cytoplasm. However, these modifications are not accompanied by a reduction of the intercellular adhesiveness or a loss of
E-cadherin
expression. Moreover, the formation of intercellular contacts between fibroblastic-like
NBT
-II cells results in the relocation of
epithelial cadherin
(
E-cadherin
) immunoreactivity on lateral membranes, but is not sufficient to abrogate cell motility. Finally, the overexpression of
E-cadherin
by
NBT
-II cells stably transfected with a plasmid containing the mouse
E-cadherin
cDNA does not impair the scattering effect of aFGF, indicating that high levels of
E-cadherin
expression do not prevent cells from disrupting their intercellular connections. Altogether, these results suggest that the scattering activity of aFGF is not mediated by direct modulations of
E-cadherin
expression.
...
PMID:E-cadherin expression during the acidic FGF-induced dispersion of a rat bladder carcinoma cell line. 137 93
