Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D02003 (NBT)
 1,323 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study was made of the level, viability and functional activity of alveolar macrophages (AM) in lavage of 86 patients with chronic bronchitis (26 with nonobstructive and 60 with obstructive bronchitis). A decrease in AM viability by 11-25%, phagocytic activity 1.6-4.6-fold, the NBT-test 1.5-3.4-fold and an increase in acid phosphatase activity more than 2-fold were revealed. The degree of a decrease in AM activity depended on the presence of bronchial tree obstruction and the purulent nature of inflammation. Treatment (a total of 33 patients were examined) resulted in an increase in AM content and viability however AM functional properties did not return to normal completely, the rate of positive shifts in activity indices did not correlate with clinical manifestations. An analysis of the dependence of AM functional activity on the type of drug therapy showed that tetracycline inhibited AM functional activity, ampicillin made a favorable effect on the restoration of AM function and beclomet stimulated significantly AM activity.
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PMID:[Functional status of alveolar macrophages in different forms of chronic bronchitis during treatment]. 360 95

Kanamycin and ampicillin alone or in combination with leucocytic pyrogen, pyrogenal and prodigiozan were tested in cultures of peritoneal macrophages infected with Shigella. The function of the cells was estimated by the phagocytosis indices (with an account of the phases of the Shigella absorption and digestion) and activity of the oxidation-reduction (the NBT test) and hydrolytic (acid phosphatase) enzymes. The inhibitory effect of the antibiotics on the functional activity of the cultivated macrophages was shown. In the presence of kanamycin a decrease in the absorptive and digestive functions of the cells with respect to Shigella was observed. The decreased activity of the oxidation-reduction enzymes and acid phosphatase in the cells almost at all observation periods was also evident of inhibition of the phagocytosis terminal phase, i.e. the intracellular digestion of the bacteria. The use of ampicillin resulted in lower levels of Shigella absorption, while the phase of the bacteria digestion remained pronounced. At the same time the decreased activity of the lysosomal enzyme (acid phosphatase) participating in intracellular digestion of Shigella was characteristic of a clear tendency to their inhibition in the presence of ampicillin. The preliminary treatment of the cells with leucocytic pyrogen, pyrogenal and prodigiozan eliminated partially or completely the inhibitory effect of the antibiotics on the functional activity of the cultivated macrophages.
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PMID:[Effect of antibiotics and stimulants on the functional activity of cultured macrophages]. 730 15