Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: KEGG:D02003 (NBT)
 1,323 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A study was made of the level, viability and functional activity of alveolar macrophages (AM) in lavage of 86 patients with chronic bronchitis (26 with nonobstructive and 60 with obstructive bronchitis). A decrease in AM viability by 11-25%, phagocytic activity 1.6-4.6-fold, the NBT-test 1.5-3.4-fold and an increase in acid phosphatase activity more than 2-fold were revealed. The degree of a decrease in AM activity depended on the presence of bronchial tree obstruction and the purulent nature of inflammation. Treatment (a total of 33 patients were examined) resulted in an increase in AM content and viability however AM functional properties did not return to normal completely, the rate of positive shifts in activity indices did not correlate with clinical manifestations. An analysis of the dependence of AM functional activity on the type of drug therapy showed that tetracycline inhibited AM functional activity, ampicillin made a favorable effect on the restoration of AM function and beclomet stimulated significantly AM activity.
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PMID:[Functional status of alveolar macrophages in different forms of chronic bronchitis during treatment]. 360 95

A total of 33 patients with chronic pyoobstructive bronchitis with immunological disorders (of T-cell and other links) and nonspecific responsiveness. The use of thymogen in multi-modality treatment contributed to normalization of T-cell immunity (increases in E-rosette formation, responses of blast cell transformation to phytohemagglutinin, Tx/Tc ratio), as well as nonspecific responsiveness parameters (C3c, NBT-test, natural killers), resulting in higher clinical efficacy.
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PMID:[Changes of immune and non-specific reactivity in patients with chronic suppurative obstructive bronchitis in comprehensive treatment with thymogen]. 798 17

The aim of this study is to assess the impact of some selected bacteriological factors on the occurrence of subglottic laryngitis in children. The research covered 72 children hospitalized in the Children's Hospital in Warsaw with the following symptoms: dry barking cough, stridor, inspiratory dyspnoea with the participation of auxiliary respiratory muscles, agitation and change of colour of skin. Subglottic laryngitis is one of the acute children's diseases, directly caused by a violently growing odema of the subglottic area. The disease constitutes 5-8% of all severe airways inflammations and states that subglottic laryngitis is responsible for 6.5% off all lower airways inflammation cases. Based on preliminary examinations, the patients were divided into two groups--one of them composed of 41 patients with simultaneous atopy, the other--of 31 patients with no atopy symptoms. The examination of each patient included subjective, objective (pediatric and laryngological) and auxiliary (primary-blood cell count, OB and specialized-bacteriological tests) examinations. Own research showed that out of 72 patients with subglottic laryngitis 56.95% had bacterial symptoms. 90.32% in non atopic group have higher NBT test, in atopic children it was 39.02%. We observed that 50.51% of the patients suffering from subglottic laryngitis had an inflammation of upper airways (otitis media, rhinitis, pharyngitis) and 13.89% of lower respiratory tract (bronchitis, pneumonitis). Many authors incline to say that bacteria may be a conductive factor for subglottic laryngitis to develop. However, many factors seem to suggest that the occurrence and symptoms of subglottic laryngitis are primarily caused by the reaction to an infection. The impact of bacteria onto the etiopathogenesis of subglottic laryngitis has been discussed for many years. Some experts are of the opinion that the disease develops on the bacteriologic background.
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PMID:[The role of the bacterial inflammation in subglottic laryngitis in children]. 1787 17